Disodium Cromoglycate in the Treatment of Bronchial Asthma

Changes in blood gas tensions and functional residual capacity in chronic asthmatics treated with disodium cromoglycate

“…The improvement in F.E.V.1 recorded for this group of 28% (mean figures 110 to 1 41 1.) is in accord with the results of Altounyan and Howell (1967) and Kidner et al (1968). Changes in F.V.C.…”

“…Changes in F.V.C. were given by Morrison Smith and Devey (1968) and commented on by Kidner et al (1968). Other trials did not analyse their data in this respect.…”

Inhibition of Allergic Reactions in Man and Other Species by Cromoglycate

“…The value of disodium cromoglycate (TntaP) in the treatment of asthma, particularly of the allergic type, which is presumably mediated by reagins, has been the subject of several recent reports [Altounyan, 1967;H ow ell and Altounyan, 1967;G rant, C hannell and D rever, 1967;K ennedy, 1967;Smith and D evey, 1968;Lopez, Franklin and Lowell, 1968;K inder et al, 1968;C hen et al, 1968;H erxheimer and Bewersdorff, 1969]. Clinical improvement was reported in a variable proportion of patients in different trials.…”

Disodium Cromoglycate in the Prevention of Induced Asthma

“…It is not surprising that the authors report improvement of about 50%, the same percentage which has been reported with many other so-called asthma remedies which have long been forgotten. In these circumstances we reluctantly agree with the unenthusiastic attitude of Kidner et al (1968), who found an improvement in 38% of their 28 patients but say that the difference between cromoglycate and placebo was seldom striking. We can also agree with Grant (1968Grant ( , 1969, who did not see a statistically significant degree of improvement.…”