Inhibition of Allergic Reactions in Man and Other Species by Cromoglycate

Assem, E. S. K.; Mongar, J. L.

doi:10.1159/000230260

Cited by 110 publications

(43 citation statements)

References 5 publications

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“…This effect appears to be similar to that produced by cromoglycate when used for bronchial asthma in man. However, pretreatment with cromoglycate aerosols, with concentrations as high as 100 mg/ml, did not significantly delay the onset of antigen-induced bronchoconstriction (unpublished observations); this is in accord with the observation of Assem & Mongar (1970) that cromoglycate is unable to prevent anaphylactic release of histamine from guinea-pig lungs. Our findings are not at variance with the idea that zinc may have acted through a different mechanism to stabilize the mast cell membrane.…”

supporting

confidence: 75%

THE EFFECT OF ZINC ON ANAPHYLAXIS in vivo IN THE GUINEA‐PIG

Cho

Dai

Ogle

1977

British J Pharmacology

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The protective effects of pretreatment with zinc sulphate aerosols against bronchoconstriction induced by egg albumen or histamine aerosols were assessed in sensitized or non-sensitized guinea-pigs respectively. Pretreatment with an adequate concentration of zinc sulphate aerosol significantly prolonged the time of onset of bronchoconstriction in sensitized guinea-pigs challenged with egg albumen, but did not appreciably alter the onset time of histamine-induced bronchoconstriction in non-sensitized animals. These findings suggest that zinc aerosols may be of prophylactic value against bronchoconstriction of allergic origin.

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supporting

confidence: 75%

THE EFFECT OF ZINC ON ANAPHYLAXIS in vivo IN THE GUINEA‐PIG

Cho

Dai

Ogle

1977

British J Pharmacology

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“…A similar lack of inhibitory effect of SCG on allergen challenge was found by Pearce et al (1974) using sensitised human skin in vitro. In the only published study to examine its in vivo effect in human skin, Assem & Mongar (1970) found SCG to be ineffective in one patient in whom mixtures of SCG and allergen were skin prick tested and in three other patients in whom PrausnitzKustner reactions were performed, although they used a narrower range of drug concentrations than we employed. One explanation for these results might be that mast cells in the skin are inaccessible to SCG, perhaps due to its lipid insolubility, but this hypothesis appears unlikely in view of the fact that in vitro studies reveal similar results (Pearce et al, 1974).…”

Section: Discussionmentioning

confidence: 89%

“…Furthermore, SCG is capable of inhibiting the PCA reaction in rat skin indicating that mast cells in this situation are accessible to the drug (Goose & Blair, 1969). SCG has been shown to inhibit mediator release from chopped human lung, but it has no significant effect on sensitized human leucocytes (Assem & Mongar, 1970). It may be that mast cells in the skin differ in some critical way from those in the lung.…”

Section: Discussionmentioning

confidence: 99%

A comparison of the in vivo effects of ketotifen, clemastine, chlorpheniramine and sodium cromoglycate on histamine and allergen induced weals in human skin.

Phillips¹,

Thomas²,

Moodley³

et al. 1983

Brit J Clinical Pharma

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1 The effect of ketotifen was compared with that of clemastine and chlorpheniramine, known antihistamines, and sodium cromoglycate, a drug considered to have mast cell 'stabilizing' properties on histamine and allergen wealing reactions in human skin, in random order, double-blind, placebo controlled studies. 2 Ketotifen was significantly more potent in the inhibition of both histamine (P < 0.001) and allergen (P < 0.001) skin wealing reactions than either clemastine or chlorpheniramine. Sodium cromoglycate had no significant effect on either histamine or allergen skin wealing reactions in any of the concentrations tested. 3 However ketotifen, like clemastine, had a significantly greater inhibitory effect on histamine than on allergen induced weals (P < 0.001) and both drugs were shown to act as competitive antagonists of histamine. 4 Ketotifen has been shown to be a potent anti-histamine but there is no evidence from these in vivo studies to suggest that it has any additional inhibitory activity on release of mediators from mast cells in human skin.

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“…Attempts to reproduce the inhibitory effect of SCG in antigen-induced anaphylactic models in guinea-pigs have met with mixed success. It has been suggested that anaphylactic reactions in animals mediated by the heat-labile mercaptoethanol-sensitive reagin type antibody are more readily inhibited by SCG than anaphylactic reactions mediated by non-reaginic antibodies (Cox, 1967;Lopez & Bloch, 1969;Assem & Mongar, 1970;Church, 1978). Lack of inhibition of guinea-pig PCA by SCG was reported by Cox (1967) and Martin (1971).…”

Section: Discussionmentioning

confidence: 99%

Antigen‐induced Bronchial Anaphylaxis in Actively Sensitized Guinea‐pigs: Anti‐anaphylactic Effects of Sodium Cromoglycate and Aminophylline

Andersson

1980

British J Pharmacology

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The inhibitory effects of sodium cromoglycate (SCG) and aminophylline on antigen‐induced bronchial anaphylaxis in guinea‐pigs, actively sensitized according to different regimens, were examined. SCG (1 mg/kg administered intravenously) reduced the anaphylactic response in animals sensitized with 1 μg ovalbumin (OA) together with Al(OH)3 100 mg, and challenged at 14 and 40 days after sensitization. If higher doses of antigen (10 μg OA together with Al (OH)3 or 5 mg OA on day 0 plus 10 mg OA on day 2) were used for sensitization, the protective effect of SCG was found only in animals tested 14 days after sensitization. A low dose of aminophylline (0.3 mg/kg) that was without a direct bronchodilator effect when tested against a histamine (4 μg/kg)‐induced bronchospasm, produced an anti‐anaphylactic effect. The anti‐anaphylactic effect of aminophylline varied slightly with the way the animals were immunized and the time at which they were tested. It is concluded that bronchial anaphylaxis in guinea‐pigs sensitized with low doses of ovalbumin is a suitable model for the evaluation of anti‐anaphylactic properties of drugs.

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Inhibition of Allergic Reactions in Man and Other Species by Cromoglycate

Cited by 110 publications

References 5 publications

THE EFFECT OF ZINC ON ANAPHYLAXIS in vivo IN THE GUINEA‐PIG

THE EFFECT OF ZINC ON ANAPHYLAXIS in vivo IN THE GUINEA‐PIG

A comparison of the in vivo effects of ketotifen, clemastine, chlorpheniramine and sodium cromoglycate on histamine and allergen induced weals in human skin.

Antigen‐induced Bronchial Anaphylaxis in Actively Sensitized Guinea‐pigs: Anti‐anaphylactic Effects of Sodium Cromoglycate and Aminophylline

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