Disorder of Sex Development: A Case of Late-Diagnosed Ovotestis and Its Postsurgical Follow-up

Bruno, Zenilda Vieira; Nogueira, Camila Sampaio; Saintrain, Maria Vieira de Lima; Nobre, Nadiejda Mendonça Aguiar; Cavalcante, Diane Isabelle Magno; Gomes, Nadia Dantas; Dias, Maria Tereza Pinto Medeiros

doi:10.1016/j.jpag.2020.03.007

Cited by 3 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…128 A female patient with ovotesticular DSD and atypical genitalia had significant pubic hair and menarche starting at 15, and was noted to have no acne or hirsutism despite elevated testosterone. 129 A male patient was diagnosed with ovotesticular DSD after evaluation for lack of male puberty, as well as estradiol levels above male reference ranges, and he was noted to have no acne or facial hair growth. 130 Two patients with chimeric ovotesticular DSD reported pigmentation alterations: ipsilateral Blaschkoid hyperpigmentation along the shoulder and arm in a male presenting with a unilateral scrotal mass, 131 and hypopigmented and hyperpigmented patches along the back in a newborn with atypical genitalia.…”

Section: Ovotesticular Dsdmentioning

confidence: 99%

Dermatologic care of patients with differences of sex development

Gold,

Huang,

Radi

et al. 2023

International Journal of Women’s Dermatology

View full text Add to dashboard Cite

Background: Differences of sex development (DSD or disorders of sex development) are uncommon congenital conditions, characterized by atypical development of chromosomal, gonadal, or anatomic sex. Objective: Dermatologic care is an important component of the multidisciplinary care needed for individuals with DSD. This article discusses the most common primary dermatologic manifestations of DSD in addition to the cutaneous manifestations of hormonal and surgical therapies in individuals with DSD. Data sources: Published articles including case series and case reports on PubMed. Study selections: Selection was conducted by examining existing literature with a team of multidisciplinary specialists. Methods: Narrative review. Limitations: This article was not conducted as a systematic review. Results: In Klinefelter syndrome, refractory leg ulcers and incontinentia pigmenti have been described. Turner syndrome is associated with lymphatic malformations, halo nevi, dermatitis, and psoriasis. Virilization can be seen in some forms of congenital adrenal hyperplasia, where acne and hirsutism are common. Conclusion: Dermatologists should consider teratogenic risk for treatments of skin conditions in DSD depending on pregnancy potential. Testosterone replacement, commonly used for Klinefelter syndrome, androgen insensitivity syndrome, 5-alpha reductase deficiency, gonadal dysgenesis, or ovotesticular DSD, may cause acne.

show abstract

Section: Ovotesticular Dsdmentioning

confidence: 99%

Dermatologic care of patients with differences of sex development

Gold,

Huang,

Radi

et al. 2023

International Journal of Women’s Dermatology

View full text Add to dashboard Cite

show abstract

“…I am eager to institute some of the elements of enhanced recovery after surgery that are described in this issue of the Journal of Pediatric and Adolescent Gynecology (JPAG). 4 Our patients are still experiencing the usual PAG concerns that are also addressed in this issue: symptomatic labial adhesions, 5 prepubertal vaginal bleeding, 6 chronic pelvic pain, 7 sexually transmitted infections, 8 issues related to contraception and induced abortion, 9e14 adnexal masses, 15,16 differences of sex development, 17 and M € ullerian anomalies, 18,19 among many other problems. The NASPAG Position Statement, published in this issue, highlights the ongoing reproductive health needs of adolescents during a pandemic, including the need for contraception and confidential healthcare, even when using telehealth platforms.…”

mentioning

confidence: 99%