Disorders of the anxiety-depressive spectrum in inflammatory bowel diseases (psychosomatic correlations)

Ромасенко, Л. В.; Махов, В. М.; Isaykina, M A

doi:10.17116/jnevro20191190419

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…This improvement in functional activity we identified in those receiving the proactive pain protocol thus further suggests improved pain-control relative to usual care. Increased step count is also known to reduce the risk of deep vein thrombosis (DVT), depression, and anxiety, which are all known complications of patients admitted for IBD flare 26 , 27 . These exploratory analyses warrant further study.…”

Section: Discussionmentioning

confidence: 99%

A randomized controlled trial of a proactive analgesic protocol demonstrates reduced opioid use among hospitalized adults with inflammatory bowel disease

Berry,

Takakura,

Patel

et al. 2023

Sci Rep

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Most hospitalized patients with inflammatory bowel disease (IBD) experience pain. Despite the known risks associated with opioids in IBD including risk for misuse, overdose, infection, readmission, and even death, opioid use is more prevalent in IBD than any other chronic gastrointestinal condition. Most hospitalized IBD patients receive opioids; however, opioids have not been shown to improve pain during hospitalization. We conducted a randomized controlled trial in hospitalized patients with IBD to evaluate the impact of a proactive opioid-sparing analgesic protocol. Wearable devices measured activity and sleep throughout their hospitalization. Chronic opioid users, post-operative, and pregnant patients were excluded. The primary endpoint was a change in pain scores from admission to discharge. Secondary endpoints included opioid use, functional activity, sleep duration and quality, and length of stay. Of 329 adults with IBD evaluated for eligibility, 33 were enrolled and randomized to the intervention or usual care. Both the intervention and control group demonstrated significant decreases in pain scores from admission to discharge (− 2.6 ± 2.6 vs. − 3.0 ± 3.2). Those randomized to the intervention tended to have lower pain scores than the control group regardless of hospital day (3.02 ± 0.90 vs. 4.29 ± 0.81, p = 0.059), used significantly fewer opioids (daily MME 11.8 ± 15.3 vs. 30.9 ± 42.2, p = 0.027), and had a significantly higher step count by Day 4 (2330 ± 1709 vs. 1050 ± 1214; p = 0.014). There were no differences in sleep duration, sleep quality, readmission, or length-of-stay between the two groups. A proactive analgesic protocol does not result in worsening pain but does significantly reduce opioid-use in hospitalized IBD patients.Clinical trial registration number: NCT03798405 (Registered 10/01/2019).

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Section: Discussionmentioning

confidence: 99%

A randomized controlled trial of a proactive analgesic protocol demonstrates reduced opioid use among hospitalized adults with inflammatory bowel disease

Berry,

Takakura,

Patel

et al. 2023

Sci Rep

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show abstract

“…Increased step count is also known to reduce the risk of deep vein thrombosis (DVT), depression, and anxiety, which are all known complications of patients admitted for IBD are. 26,27 These exploratory analyses warrant further study.…”

Section: Healthcare Utilizationmentioning

confidence: 98%

Effects of a Proactive Analgesic Protocol On Pain and Opioid Use in Hospitalized Patients with Inflammatory Bowel Disease: Results from a Randomized Control Trial

Berry

Takakura

Patel

et al. 2022

Preprint

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Background: Most hospitalized patients with inflammatory bowel disease (IBD) experience pain. Despite the known risks associated with opioids in IBD including risk for misuse, overdose, infection, readmission, and even death, opioid use is more prevalent in IBD than any other chronic gastrointestinal condition. Most hospitalized IBD patients receive opioids; however, opioids have not been shown to improve pain during hospitalization. Methods: We conducted a randomized controlled trial in hospitalized patients with IBD to evaluate the impact of a proactive opioid-sparing analgesic protocol. Wearable devices measured activity and sleep throughout their hospitalization. Chronic opioid users, post-operative, and pregnant patients were excluded. The primary endpoint was a change in pain scores from admission to discharge. Secondary endpoints included opioid use, functional activity, sleep duration and quality, and length of stay.Results: Of 329 adults with IBD evaluated for eligibility, 33 were enrolled and randomized to the intervention or usual care. Both the intervention and control group demonstrated significant decreases in pain scores from admission to discharge (-2.6±2.6 vs. -3.0±3.2). Those randomized to the intervention had lower pain scores than the control group regardless of hospital day (3.02±0.90 vs 4.29±0.81, p=0.059), used significantly fewer opioids (daily MME 11.8±15.3 vs 30.9±42.2, p=0.027), and had a significantly higher step count by Day 4 (2330±1709 vs 1050±1214; p=0.014). There were no differences in sleep duration, sleep quality, readmission, or length-of-stay between the two groups.Conclusions: A proactive analgesic protocol does not result in worsening pain but does significantly reduce opioid-use in hospitalized IBD patients.

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“…Very often psychosomatic disorders are the cause of gastrointestinal diseases. A study by Romascenko et al(23) demonstrated that 72 % of patients suffering from Crohn disease, had affective mental disorders. Taking into account other areas of medicine, the results obtained byBrumm and Schnell (24) confirm that training course in basic psychosomatic attention, should be included in the specialist training of ophthalmologists(24).…”

mentioning

confidence: 99%

Psychosomatic aspects of motion and seasickness - a literature review and evaluation according to QUADAS-2 tool

Podstawka¹,

Zieliński²,

Gawda³

2020

J Educ Health Sport

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Disorders of the anxiety-depressive spectrum in inflammatory bowel diseases (psychosomatic correlations)

Cited by 4 publications

References 9 publications

A randomized controlled trial of a proactive analgesic protocol demonstrates reduced opioid use among hospitalized adults with inflammatory bowel disease

A randomized controlled trial of a proactive analgesic protocol demonstrates reduced opioid use among hospitalized adults with inflammatory bowel disease

Effects of a Proactive Analgesic Protocol On Pain and Opioid Use in Hospitalized Patients with Inflammatory Bowel Disease: Results from a Randomized Control Trial

Psychosomatic aspects of motion and seasickness - a literature review and evaluation according to QUADAS-2 tool

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