2022
DOI: 10.14814/phy2.15410
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Disparate biomechanical properties of the aorta in non‐aneurysmal and aneurysmal mice treated with angiotensin II

Abstract: In vivo angiotensin II (AngII)-treatment is a widely used experimental model to induce cardiovascular disease and results in a high likelihood of abdominal aorta aneurysm (AAA) formation. This involves progressive and irreversible focal dilation of the abdominal aorta and induces adverse aortic connective tissue remodeling contributing to aortic wall stiffening through inflammation, elastin degradation, and collagen restructuring. Hence, the present study aimed to investigate how AAA formation in AngII-treated… Show more

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