Disparate Host Response and Donor Survival After the Transplantation of Mesenchymal or Neuroectodermal Cells to the Intact Rodent Brain

Abstract

Our findings suggest that intrinsic characteristics of mesenchymal cells may stimulate host inflammation, and thus may not represent an ideal donor source for transplantation to the adult brain.

Pulmonary Passage is a Major Obstacle for Intravenous Stem Cell Delivery: The Pulmonary First-Pass Effect

“…Four hours after the injection, distributions of PBSCs were 42.12% in spleen, 21.3% in liver, and only 5.8% in lung [17]. These studies suggest that pulmonary trapping of MSC transplanted into adults rat brains stimulated a host infl ammation resulting in acute rejection of the implanted cells [20,21]. An immune response might also be responsible for the pulmonary tissue damage observed by Anjos-Afonso et al [19].…”

Transplantation of umbilical cord–derived mesenchymal stem cells as a novel strategy to protect the central nervous system: technical aspects, preclinical studies, and clinical perspectives

“…Further studies are therefore required to clarify whether immunosuppression is a help or a hindrance in obtaining the most beneficial outcomes in xenotransplantation experiments. This issue appears even more controversial when one considers that rat BM-MSCs when transplanted into the normal adult rat brain elicit a severe inflammatory response, leading to graft rejection by 2 wk (90,99). In addition, human BM-MSCs can induce or inhibit the proliferative response of allogeneic lymphocytes in vitro, depending on the number of MSCs present (100).…”

Nonviral gene delivery of erythropoietin by mesenchymal stromal cells

“…13 However, numerous studies suggest that MSCs do not persist in the recipient organism for prolonged periods of time. 26 We detected GFP-expressing cells in the liver, intestinal tract and lymphoid tissues at 7 days post transplantation, but the results were ambiguous (data not shown). In most settings, the survival of MSCs does not exceed the maximal duration of transgene expression after nonviral gene transfer.…”