Disparities in Access to Corneal Tissue in the Developing World

Liu, Catherine; Saeed, Hajirah N.

doi:10.1080/08820538.2022.2152714

Cited by 1 publication

(1 citation statement)

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“…It is located in the anterior portion of the eyeball. Globally, corneal disease is a common cause of blindness, and keratoplasty is seen to be the most successful treatment to regain vision [2]. However, for keratoplasty, the major problem is the severe shortage of donor corneas and high-quality artificial corneas [3].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of a Photo-Crosslinked Methacryloyl-Collagen Composite Film to Promote Corneal Nerve Regeneration via Surface Grafting of Taurine Molecules

Liu

Zhang

Kong

et al. 2023

IJMS

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Blindness is frequently caused by corneal abnormalities, and corneal transplantation is the most effective treatment method. It is extremely important to develop high-quality artificial corneas because there are not enough donor corneas accessible for cornea transplantation. One of the most-often utilized materials is collagen, which is the primary component of natural cornea. Collagen-based corneal repair materials have good physicochemical properties and excellent biocompatibility, but how to promote the regeneration of the corneal nerve after keratoplasty is still a big challenge. In this research, in order to promote the growth of nerve cells on a collagen (Col) substrate, a novel collagen-based material was synthesized starting from the functionalization of collagen with unsaturated methacryloyl groups that three-dimensionally photopolymerize to a 3D network of chemically crosslinked collagen (ColMA), onto which taurine molecules were eventually grafted (ColMA-Tr). The physicochemical properties and biocompatibility of the Col, ColMA and ColMA-Tr films were evaluated. By analyzing the results, we found that all the three samples had good moisture retention and aq high covalent attachment of methacryloyl groups followed by their photopolymerization improved the mechanical properties of the ColMA and ColMA-Tr. Most importantly, compared with ColMA, the taurine-modified collagen-MA film significantly promoted the growth of nerve cells and corneal epithelial cells on its surface. Our preliminary results suggest that this novel ColMA-Tr film may have potential use in cornea tissue engineering in the future.

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Section: Introductionmentioning

confidence: 99%