Disparities in Periodontitis Prevalence among Chronic Kidney Disease Patients

Ioannidou, Effie; Swede, Helen

doi:10.1177/0022034511402209

Cited by 48 publications

(69 citation statements)

References 27 publications

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“…A recent cohort study showed that severe periodontitis is associated with kidney dysfunction in African Americans (Grubbs et al, 2015). Other clinical studies have also demonstrated a close association between CKD and periodontal disease (Ioannidou & Swede, 2011; Iwasaki et al, 2012). …”

Section: Introductionmentioning

confidence: 84%

Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Naruishi

Oishi

Inagaki

et al. 2016

Clinical & Exp Dental Res

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Recent studies have demonstrated that chronic kidney disease (CKD) may be associated with the progression of periodontal disease. Diabetes mellitus (DM) is a major risk factor for CKD. The objective of this study was to clarify the relationship between periodontal condition and kidney dysfunction in patients who had kidney failure with or without DM. One hundred sixty‐four patients with kidney dysfunction were enrolled (male: N = 105; female: N = 59), and the relationship between periodontal condition and kidney dysfunction was analyzed in a cross‐sectional study. The subjects were divided into three groups: (a) patients with DM, (b) dialysis patients with nephropathy due to various kidney diseases, and (c) dialysis patient with nephropathy due to DM (diabetic nephropathy). Then, the effect of DM on the periodontal condition was analyzed. The patients were also stratified by CKD stage (into G1–G5) using the estimated glomerular filtration rate (eGFR), and the G5 group was divided in patients with or without DM. Correlations between eGFR and parameters of periodontal condition were calculated in patients from G1 to G4. The number of missing teeth was significantly higher in dialysis patients with diabetic nephropathy than in patients with DM, whereas alveolar bone loss did not show a significant difference among the three groups. In addition, the G5 patients with DM had a significantly higher number of missing teeth than the other CKD groups, whereas alveolar bone loss did not show a significant difference. In G5 patients with DM, Community Periodontal Index and Oral Hygiene Index scores were significantly higher than in G1‐4 patients with DM. There was a significant negative correlation between eGFR and the number of missing teeth. Patients with diabetic nephropathy have a higher rate of periodontal problems such as missing teeth in Japanese adults.

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Section: Introductionmentioning

confidence: 84%

Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Naruishi

Oishi

Inagaki

et al. 2016

Clinical & Exp Dental Res

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“…First, compared with previous studies (Kshirsagar et al, 2005;Fisher et al, 2008), we used a more recent periodontitis case definition (Page and Eke, 2007), which has been adopted in official US public health publications on the national prevalence of periodontitis (Dye et al, 2007). This is important, since we have shown previously that the choice of periodontitis case definition affects associations with renal function (Ioannidou and Swede, 2011). Second, we estimated GFR based on cystatin C levels, which have been shown to provide more accurate estimates compared with creatinine, which depends heavily on muscle mass, age, sex, and race (Stevens et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…History of cardiovascular disease (CVD) was constructed as a variable derived from the self-reported history of heart attack, stroke, heart failure, and hypertension (Kshirsagar et al, 2008). Education and income variables were constructed as reported previously (Ioannidou and Swede, 2011), whereas Body Mass Index (BMI) was calculated as body weight (kgr) divided by squared height (m 2 ) and was stratified into 4 standard categories.…”

Section: Materials and Methods Study Populationmentioning

confidence: 99%

Periodontitis Predicts Elevated C-reactive Protein Levels in Chronic Kidney Disease

Ioannidou¹,

Swede

Dongari-Bagtzoglou³

2011

J Dent Res

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Based on the existing evidence supporting a state of chronic inflammation in chronic kidney disease (CKD), we hypothesized that periodontal infection may affect the systemic inflammatory status of a nationally representative CKD population as measured by serum C-reactive protein (CRP). We examined this hypothesis using the National Health and Nutrition Examination Survey 1988-1994 (NHANES III) dataset including 2303 individuals. We followed the American Academy of Periodontology (AAP)/Centers for Disease Control and Prevention (CDC) case definition for periodontitis. We used a cutoff point of 30% sites with (PD) ≥ 5 mm and (CAL) ≥ 4 mm to define generalized periodontitis cases. We estimated glomerular filtration rate based on cystatin C levels using the relevant equation. Urinary albumin-to-creatinine ratio was calculated in milligrams per gram with a cutoff point of 30 mg/g. CKD was defined based on eGFR < 60 mL/min/1.73m 2 and albuminuria ≥ 30 mg/g. Periodontitis was found in 427 (12.3%) individuals. Of individuals with periodontitis, 41.8% had serum CRP higher than 0.3 mg/dL compared with 27.1% of non-periodontitis and 53.1% of edentulous individuals (p = 0.001 for all comparisons). When the extent of periodontitis was used as one of the independent variables, the parsimonious model showed a strong independent association between extent of periodontitis and serum CRP levels (OR = 2.0, CI95% = 1.2-3.6).

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“…Chronic periodontitis constitutes one of the factors that contribute to the development of chronic kidney disease, and the relationship between those two entities is bi-directional [15][16][17][18][19].…”

Section: Chronic Kidney Disease and Periodontal Statusmentioning

confidence: 99%

Oral Health in Chronic Kidney Disease Patients: A Literature Review

Rabiega¹,

Eliasz²,

Pawlaczyk³

2016

Dent. Med. Probl.

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Chronic kidney disease (CKD) is a broad term used to describe progressive structural and functional kidney disorders that may be accompanied by a decrease in the glomerular filtration rate (GFR), and that have lasted for at least 3 months [1]. The diagnosis of CKD is also made if GFR values are below 60 mL/min/1.73 m 2 for a minimum of 3 months, independently of the presence of kidney damage markers [2,3]. There are several symptoms that can indicate CKD in patients, e.g. abnormalities visible in diagnostic imaging procedures, in blood and urine tests (e.g. proteinuria, abnormal urine sediment) or blood morphology. GFR is, however, the most important factor when it comes to the physiopathology of chronic kidney disease. Nowadays, CKD is classified into five stages, according to the value of this index: stage 1 (GFR > 90 mL/ /min/1.73 m 2 ), stage 2 (60-89 mL/min/1.73 m 2 ), stage 3 (30-59 mL/min/1.73 m 2 ), stage 4 (15-29 mL/min/1.73 m 2 ) and stage 5 (GFR < 15 mL/ /min/1.73 m 2 ). Stage 3 can be further divided into 3A (45-59 mL/min/1.73 m 2 ) and 3B (30-44 mL/ /min/1.73 m 2 ). Stage 5, the most advanced and dangerous one, is also described as "end-stage renal failure" (ESRF), and constitutes an indica-REVIEWS

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Disparities in Periodontitis Prevalence among Chronic Kidney Disease Patients

Cited by 48 publications

References 27 publications

Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Periodontitis Predicts Elevated C-reactive Protein Levels in Chronic Kidney Disease

Oral Health in Chronic Kidney Disease Patients: A Literature Review

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