Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Naruishi, Koji; Oishi, Keiji; Inagaki, Yuji; Horibe, Masumi; Bando, Mika; Ninomiya, Masami; Kawahara, Katsunobu; Murata, Jun; Kawashima, Seiichiro; Shima, Kenji; Kido, Jun‐ichi; Nagata, Toshihiko

doi:10.1002/cre2.39

Cited by 12 publications

(19 citation statements)

References 32 publications

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“…Our study showed that diabetic patients with renal dysfunction had fewer remaining teeth and less likelihood to have 20 or more remaining teeth, as compared with those with normal renal function. Previous evidence consistently revealed a significant correlation between deceased kidney function and the number of missing teeth attributing to periodontal disease in patients with or without diabetes [28]. A smaller number of teeth also results in reduced inflammation from the periodontal area.…”

Section: Discussionmentioning

confidence: 89%

Chronic Periodontitis is a Risk Factor of Renal Dysfunction in Patients with Type 2 Diabetes

Zhang

Liu

Miao

et al. 2019

Exp Clin Endocrinol Diabetes

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Background This study explores the association between chronic periodontitis and renal dysfunction in type 2 diabetic mellitus (T2DM) patients. Methods An observational study was conducted in 169 T2DM patients with chronic periodontitis. Patients were divided into 2 groups according to presence of normal renal function (n=111) and renal dysfunction (n=58), and oral health behavior-related variables were obtained by questionnaire. Periodontal status was examined, and pocket probing depth (PD), clinical attachment level (CAL), and bleeding index (BI) were measured. Results The severe periodontitis group had a significant higher HbA1c level (8.53 ± 1.61%) as compared with the mild and moderate periodontitis groups (7.68±1.58%) and (7.35±1.45%), P=0.001. Compared with patients with normal renal function, patients with renal dysfunction had a higher PD value, higher CAL value, fewer remaining teeth, and were less likely to have remaining teeth ≥20. The percentage of sites with PD ≥4 mm (52.8% vs. 41.67%) was significantly greater in patients with renal dysfunction. There was no difference in the scores of oral health knowledge assessment between the 2 groups. After adjustment by gender, age, BMI, smoking, hypertension, and HbA1c, the percentage of the sites with PD≥4 mm was an independent risk factor of renal dysfunction in T2DM patients. Conclusion In patients with T2DM, those with periodontitis may be more susceptible to decreased kidney function.

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Section: Discussionmentioning

confidence: 89%

Chronic Periodontitis is a Risk Factor of Renal Dysfunction in Patients with Type 2 Diabetes

Zhang

Liu

Miao

et al. 2019

Exp Clin Endocrinol Diabetes

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“…Naruishi et al showed higher rate of periodontal problems in patients with diabetic nephropathy and negative correlation between glomerular filtration rate and the number of missing teeth in Japanese adults (26). Missing teeth were not evaluated in our study.…”

Section: Discussionmentioning

confidence: 53%

Relationship Between Oral Presentations and Diabetic Micro-Vascular Complications

et al. 2018

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Background: Oral mucosal lesions are more prevalent in diabetic patients compared to healthy individuals. Periodontal disorders have been known as the sixth complication of diabetes mellitus after microvascular and cardiovascular complications. The aim of this research was to assess the relationship between oral mucosal lesions and retinopathy and nephropathy in type 2 diabetic subjects in the Yazd province. Methods: This analytical cross-sectional study was conducted in diabetes research center during 2014-2016 in Yazd. Individuals with glomerular filtration rate (GFR) less than 60, oropharyngeal cancer, pregnancy, lactation, type one diabetes, or newly diagnosed diabetes (< 2 years) are excluded from study. The subjects' demographic data and oral examination was performed by an oral medicine specialist. Soft tissues oral cavity findings consist of any form of candidiasis, periodontitis, gingivitis, xerostomia, geographic tongue, lichen planus, gingival hyperplasia, delay oral wound healing, fissured tongue, and burning mouth sensation. Fasting blood sugar (FBS), HbA1c, and micro-albuminuria were checked. Diabetic nephropathy defined to the urinary excretion rate of albumin above 30 mg/g creatinine. The retinal specialist evaluated diabetic retinopathy. Finally, frequency of soft tissue oral lesions in individuals with and without retinopathy and nephropathy were compared. We analyzed data using the SPSS version 20. Statistical significance less than 0.05 were accepted. Results: Totally, 274 patients (48% male) participated in this study. Most of the patients (70.8%) suffer from at least one of the diabetic microvascular complications (retinopathy, nephropathy or both) and 80 diabetic patients (29.2%) had no complications. Gingivitis (P = 0.049) and fissured tongue (P = 0.047) were more prevalent in retinopathic individuals compared to subjects without retinopathy. Fissured tongue and delayed wound healing were high in nephropathic persons compared to other groups (P = 0.047 and 0.039, respectively). Presence of at least one of the oral lesions are higher than in patients with retinopathy and nephropathy compared to individuals without complications (P = 0.047 and 0.049 respectively). Conclusions: High frequency of oral problems in subjects with micro-vascular complications were found. Our findings showed that closer cooperation between the endocrinologist and the oral medicine specialist is required. In addition, diagnosis of oral problems in diabetics, especially with micro-vascular complications, is necessary to improve the oral health of them.

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“…Some studies compared diabetic versus nondiabetec ESRD patients. However, there were no significant differences between diabetic and nondiabetic ESRD patients regarding several periodontal parameters (Chuang et al, 2005;Murali et al, 2012;Naruishi et al, 2016;Swapna et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Oral health in patients with end‐stage renal disease: A scoping review

Laheij

Rooijers

Bidar

et al. 2021

Clinical & Exp Dental Res

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Objectives: In patients with end stage, renal disease a high rate of morbidity and mortality is present. Studies suggest that end stage renal disease may affect oral health. Therefore, the aim of this study was to perform a scoping review on periodontal disease, dental caries, xerostomia, and hyposalivation in end stage renal disease patients. Materials and methods:A literature search (in PubMed and Embase.com) was performed up to September 29, 2020, in collaboration with a medical information specialist. Included outcome variables were the community periodontal index, probing pocket depth, gingival index, bleeding on probing, decayed-missing-filled-teeth, carious-absent-obturated index, Xerostomia Inventory and the (un)stimulated whole salivary flow rate.Results: Forty three out of 1293 studies were included in the final review comprising 7757 end stage renal disease patients. The average age was 58.3 ± 29.4 years.28.2%-78.8% of patients reported xerostomia and the (un)stimulated salivary flow rates were significantly lower. Higher community periodontal index scores were measured in end stage renal disease patients. More decayed-missing-filled-teeth were recorded, but no differences were found between groups.Conclusions: Xerostomia and hyposalivation were highly prevalent in end stage renal disease patients. Patients have more deepened pockets, but an equal number of carious teeth compared to healthy controls.

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Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Cited by 12 publications

References 32 publications

Chronic Periodontitis is a Risk Factor of Renal Dysfunction in Patients with Type 2 Diabetes

Chronic Periodontitis is a Risk Factor of Renal Dysfunction in Patients with Type 2 Diabetes

Relationship Between Oral Presentations and Diabetic Micro-Vascular Complications

Oral health in patients with end‐stage renal disease: A scoping review

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