This introductory chapter first addresses the need to excavate a new field of global LGBTQ health as an extension of previous LGBTQ health research and scholarship and the importance of encompassing information and research from across the globe, rather than just focusing on the Global North. This chapter then discusses the genesis of the book informed by past course design, pedagogy, and conference programming in which the authors had initiated and engaged. The impact of the COVID-19 pandemic on both the editing and authoring process of this edited volume as well as on the overall field of LGBTQ health is next considered. The relevance of history, culture, and religion as well as racial/ethnic stratification and indigeneity are next examined. Intersectionality is then interrogated, especially in studying “inter-categorical” intersectionality utilizing quantitative methods. Finally, paragraph summaries for each of the chapters in the edited volume are presented, which are characterized by the following health issues and outcomes: stigma, mental health, noncommunicable diseases, community and social support, HIV, substance use, and victimization and intentional injury.