Dispersant selection for aqueous medium pressure injection moulding of anhydrous dicalcium phosphate

Jewad, Raeid; Bentham, Craig; Hancock, Bruno C.; Bonfield, William; Best, Serena M.

doi:10.1016/j.jeurceramsoc.2007.07.010

Cited by 16 publications

(9 citation statements)

References 31 publications

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“…the viscosity continually decreased as the shear rate increased. This is said to occur because of the rearrangement of particles into ordered layers which exhibit minimal resistance to separation as shear rate increases [34]. The viscosity of both slips also showed signs of convergence to a similar constant viscosity at high shear rates.…”

Section: Discussionmentioning

confidence: 99%

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High-solid-content hydroxyapatite slurry for the production of bone substitute scaffolds

Cunningham

Dunne

Walker

et al. 2009

Proc Inst Mech Eng H

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Key to various bone substitute scaffold production techniques is the development of free-flowing ceramic slurry with optimum theological properties. The aim is to achieve a colloidal suspension with as high a solid content as possible while maintaining a low viscosity which easily penetrates the pores of relevant sacrificial templates. The following investigation describes the optimization of a hydroxyapatite slip and demonstrates its potential application in scaffold production. Using predominantly spherical particles of hydroxyapatite of between 0.82 microm and 16.2 microm, coupled with a 2 wt % addition of the anionic polyelectrolyte, ammonium polyacrylate, an 80 wt % (55.9 vol%) hydroxyapatite solid loaded slip with a viscosity of approximately 126mPas has been developed. Its ability to infiltrate and replicate porous preforms has been shown using polyurethane foam. The enhanced particle packing achieved has allowed for the production of scaffolds with highly dense and uniform grain structures. The results represent a significant improvement in current slurry production techniques and can be utilized to develop high-density ceramic bone substitute scaffolds.

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Section: Discussionmentioning

confidence: 99%

“…In terms of the zeta potential, the dividing line between a stable and unstable colloidal suspension is said to be ¡30 mV [34]. Consequently, each anionic polyelectrolyte utilized, in concentrations of between 0.5 wt % and 0.4 wt %, allowed for the production of stable suspensions (Figs 4 and 5).…”

Section: Discussionmentioning

confidence: 99%

High-solid-content hydroxyapatite slurry for the production of bone substitute scaffolds

Cunningham

Dunne

Walker

et al. 2009

Proc Inst Mech Eng H

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“…However, regarding the alginate-hydroxyapatite system, the difficulties of hydroxyapatite dispersion, the viscosity of the alginate and the negative charge density of both, partially prevents their interaction. This hinders their processing together, especially for injectable materials (Bao, Senos, Almeida, & Gauckler, 2002;Jewad, Bentham, Hancock, Bonfield, & Best, 2008;Lee, Choi, Kim, & Lee, 2006). An alternative breakthrough may come from the surface functionalization of hydroxyapatite with alginate or OA.…”

Section: Remarks and New Directions In Alginate Based Bone Engineeringmentioning

confidence: 99%

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Hernández-González

Téllez-Jurado

Rodríguez‐Lorenzo

2020

Carbohydrate Polymers

406

209

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This review focuses on recently developed alginate injectable hydrogels and alginate composites for applications in bone tissue regeneration, and it evaluates the alternatives to overcome the problems that avoid their utilization in the field. Section 2 covers the properties of alginates that have made them useful for medical applications, in particular their ionic gelling ability for preparing injectable compositions used as delivery drugs systems. The advantages and shortcomings of these preparations are revised together with the chemical modifications assayed. Section 3 describes how it has been taken advantage of alginates into the new field of biofabrication and the developments in bone engineering. The state of the art of this field is reviewed. Finally in Section 4, new developments and approaches that in opinion of the authors can lead to a breakthrough in bone tissue engineering using alginates are introduced.

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“…Since calcium orthophosphates are either thermally unstable (MCPM, MCPA, DCPA, DCPD, OCP, ACP, CDHA) or have a melting point at temperatures exceeding ~1400 °C with a partial decomposition (α-TCP, β-TCP, HA, FA, TTCP), only the first and the second consolidation approaches are used to prepare bulk bioceramics and scaffolds. The methods include uniaxial compaction [198,199,200], isostatic pressing (cold or hot) [108,201,202,203,204,205,206,207], granulation [208,209,210,211,212,213], loose packing [214], slip casting [93,215,216,217,218,219,220], gel casting [188,189,221,222,223,224,225], pressure mold forming [226], injection molding [227,228,229], polymer replication [230,231,232,233,234,235,236,237], extrusion [238,239,240,241,242], slurry dipping and spraying [243]. In addition, to form ceramic sheets from slurries, tape casting [105,223,244,245,246], doctor blade [247] and colander me...…”

Section: Bioceramics Of Calcium Orthophosphatesmentioning

confidence: 99%

Calcium Orthophosphate-Based Bioceramics

Dorozhkin¹

2013

Materials

232

153

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Various types of grafts have been traditionally used to restore damaged bones. In the late 1960s, a strong interest was raised in studying ceramics as potential bone grafts due to their biomechanical properties. A bit later, such synthetic biomaterials were called bioceramics. In principle, bioceramics can be prepared from diverse materials but this review is limited to calcium orthophosphate-based formulations only, which possess the specific advantages due to the chemical similarity to mammalian bones and teeth. During the past 40 years, there have been a number of important achievements in this field. Namely, after the initial development of bioceramics that was just tolerated in the physiological environment, an emphasis was shifted towards the formulations able to form direct chemical bonds with the adjacent bones. Afterwards, by the structural and compositional controls, it became possible to choose whether the calcium orthophosphate-based implants remain biologically stable once incorporated into the skeletal structure or whether they were resorbed over time. At the turn of the millennium, a new concept of regenerative bioceramics was developed and such formulations became an integrated part of the tissue engineering approach. Now calcium orthophosphate scaffolds are designed to induce bone formation and vascularization. These scaffolds are often porous and harbor different biomolecules and/or cells. Therefore, current biomedical applications of calcium orthophosphate bioceramics include bone augmentations, artificial bone grafts, maxillofacial reconstruction, spinal fusion, periodontal disease repairs and bone fillers after tumor surgery. Perspective future applications comprise drug delivery and tissue engineering purposes because calcium orthophosphates appear to be promising carriers of growth factors, bioactive peptides and various types of cells.

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Dispersant selection for aqueous medium pressure injection moulding of anhydrous dicalcium phosphate

Cited by 16 publications

References 31 publications

High-solid-content hydroxyapatite slurry for the production of bone substitute scaffolds

High-solid-content hydroxyapatite slurry for the production of bone substitute scaffolds

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Calcium Orthophosphate-Based Bioceramics

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