Disperse systems based on chloracetophos in the low concentration range: self-organization, physicochemical properties and influence on representatives of higher plants and hydrobionts

Рыжкина, И. С.; Sergeeva, S. Yu.; Муртазина, Л. И.; Shevelev, M. D.; Akhmetzyanova, L R; Кузнецова, Т. В.; Zaynulgabidinov, E. R.; Knyazev, I. V.; Петров, А. М.; Коновалов, А. И.

doi:10.1007/s11172-018-2139-y

Cited by 11 publications

(16 citation statements)

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“…In the case of high dilutions (less than 1·10 −12 M), the actual concentration of the substance is rather difficult to confirm by experimental methods. Therefore, in our previous papers ( Konovalov and Ryzhkina, 2014 ; Ryzhkina et al, 2018a ; Ryzhkina et al, 2018b ; Ryzhkina et al, 2019 ; Ryzhkina et al, 2020 ), as well as in the present work, when discussing high dilutions corresponding to calculated concentrations from 1·10 −13 M to 1·10 −20 M, we use this very term implying the theoretically possible concentration of the substance at the corresponding dilution step.…”

Section: Methodsmentioning

confidence: 96%

“…Currently, a new physicochemical approach is being developed that explains and predicts the presence of bioeffects in water systems with low calculated concentrations 1 of substances and nonmonotonically dependent bioeffects on concentration ( Konovalov and Ryzhkina, 2014 ; Ryzhkina et al, 2018a ; Ryzhkina et al, 2018b ; Ryzhkina et al, 2019 ; Ryzhkina et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Nanoassociates are formed as the solution is being diluted only in the presence of EMF, and characterized by dimensions of hundreds of nm, a negatively charged interface, and high susceptibility to such factors as the chemical and spatial structure of solute molecules, the properties of EMF, etc. ( Konovalov and Ryzhkina, 2014 ; Ryzhkina et al, 2018a ; Ryzhkina et al, 2018b ; Ryzhkina et al, 2019 ; Ryzhkina et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…As dilution proceeds, a coherent change in the extreme values of the parameters of nanoassociates, physicochemical properties, and bioeffects of the systems are observed at practically the same critical concentrations. This made it possible to propose a hypothesis and experimentally prove that the nonmonotonic nature of the bioeffect, a change in its direction, the presence of “zones of silence” are primarily due to the transformation of the dispersed phase in the course of the systems’ dilution, rather than the decrease of the solute’s concentration ( Konovalov and Ryzhkina, 2014 ; Ryzhkina et al, 2018a ; Ryzhkina et al, 2018b ; Ryzhkina et al, 2019 ; Ryzhkina et al, 2020 ). Moreover, it follows that it is possible to predict the emergence of similar concentration dependences of bioeffects using nonmonotonous concentration dependences of nanoassociates' parameters and physicochemical properties of systems in the interval of low calculated concentrations ( Konovalov and Ryzhkina, 2014 ; Ryzhkina et al, 2018a ; Ryzhkina et al, 2018b ; Ryzhkina et al, 2019 ; Ryzhkina et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, and for the first time, it was established that the rearrangement of nanoassociates at certain low critical concentrations is accompanied not only by a significant change in physicochemical properties and bioeffects but also in the UV absorption in the 200–300 nm range ( Ryzhkina et al, 2018a ; Ryzhkina et al, 2018b ). Works ( Lobyshev et al, 1999 ; Chai et al, 2008 ; Elia et al, 2014 ; Elia et al, 2018 ; Patsaeva et al, 2018 ) have demonstrated the presence of absorption within the range of 200–350 nm in the UV spectra of natural water, aqueous solutions of BAS, and systems containing structured water in contact with a hydrophilic surface.…”

Section: Introductionmentioning

confidence: 99%

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Diluted Aqueous Dispersed Systems of 4-Aminopyridine: The Relationship of Self-Organization, Physicochemical Properties, and Influence on the Electrical Characteristics of Neurons

et al. 2021

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A variety of physicochemical methods were used to examine the self-organization, physicochemical, UV absorption, and fluorescent properties of diluted aqueous solutions (calculated concentrations from 1·10−20 to 1·10−2 M) of the membrane voltage-dependent potassium channels blocker 4-aminopyridine (4-AP). Using the dynamic light scattering method, it was shown that 4-AP solutions at concentrations in the range of 1·10−20–1·10−6 M are dispersed systems in which domains and nanoassociates of hundreds of nm in size are formed upon dilution. An interrelation between the non-monotonic concentration dependencies of the size of the dispersed phase, the fluorescence intensity (λex 225 nm, λem 340 nm), specific electrical conductivity, and pH has been established. This allows us to predict the bioeffects of the 4-AP systems at low concentrations. The impact of these diluted aqueous systems on the electrical characteristics of identified neurons of Helix lucorum snails was studied. Incubation of neurons in the 4-AP systems for which the formation of domains and nanoassociates had been established lead to a nonmonotonic decrease of the resting potential by 7–13%. An analysis of the obtained results and published data allows for a conclusion that a consistent change in the nature and parameters of the dispersed phase, as well as the pH of the medium, apparently determines the nonmonotonic nature of the effect of the 4-AP systems in a 1·10−20–1·10−6 M concentration range on the resting membrane potential of neurons. It was found that the pre-incubation of neurons in the 4-AP system with a concentration of 1·10−12 M led to a 17.0% synergistic decrease in the membrane potential after a subsequent treatment with 1·10−2 M 4-AP solution. This finding demonstrates a significant modifying effect of self-organized dispersed systems of 4-AP in low concentrations on the neurons’ sensitivity to 4-AP.

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