“…There are several studies on cell disruption of microalgae with these agents (Pavlić et al, 2005;Hung and Liu, 2006;Miao and Tao, 2009;Cheng et al, 2010;Ebenezer et al, 2012;Ulloa et al, 2012;Glembin et al, 2013;Huang and Kim, 2013), however, the product quality is highly affected by either oxidation (Saby et al, 1997;Phe et al, 2005;Virto et al, 2005) or disruption agent contamination. Some emerging technologies related to these chemicals, such as pressure-assisted ozonation (PAO) or advanced oxidation processes (AOP) and peroxone treatment, exist (Nguyen et al, 2013;Huang et al, 2014), however, they are not discussed in detail in this review because they are not considered as mild for use in the future biorefinery because of their effect on product quality.…”