The preparation of large, low-entropy, highly coherent ensembles of identical quantum systems is foundational for many studies in quantum metrology [1], simulation [2], and information [3]. Here, we realize these features by leveraging the favorable properties of tweezer-trapped alkaline-earth atoms [4][5][6] while introducing a new, hybrid approach to tailoring optical potentials that balances scalability, high-fidelity state preparation, site-resolved readout, and preservation of atomic coherence. With this approach, we achieve trapping and optical clock excited-state lifetimes exceeding 40 seconds in ensembles of approximately 150 atoms. This leads to half-minute-scale atomic coherence on an optical clock transition, corresponding to quality factors well in excess of 10 16 . These coherence times and atom numbers reduce the effect of quantum projection noise to a level that is on par with leading atomic systems [7,8], yielding a relative fractional frequency stability of 5.2(3) × 10 −17 (τ /s) −1/2 for synchronous clock comparisons between sub-ensembles within the tweezer array. When further combined with the microscopic control and readout available in this system, these results pave the way towards long-lived engineered entanglement on an optical clock transition [9] in tailored atom arrays.