Displasia renal em um cão

Hünning, Paula Stieven; Aguiar, Juliana; Lacerda, Luciana de Almeida; Sonne, Luciana; Oliveira, Eduardo Conceição de; Haas, Gabriela Fernanda

doi:10.22456/1679-9216.16192

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…At cut surface, attention is drawn to cortical-medullary alteration and dilation of the pelvis, similar to descriptions in the literature [12]. The differential diagnosis for this type of macroscopic presentation would be the terminal kidney that occurs in older dogs [3].…”

Section: Discussionmentioning

confidence: 97%

“…In addition, supportive treatment was prescribed with hypercaloric vitamin supplement (Nutralife intensiv ® ) 4 2 measures every 24 h, Renadog ®5 2 small measures every 24 h. After 3 days, investigations for urea (325 mg/dL) and creatinine (5.25 mg/dL) were repeated, which showed a significant improvement, with clinical worsening of the patient's condition. One week after begining of treatment, the patient returned to the clinic with convulsive episodes, which were treated with diazepam (1 mg/kg IV) 3 , but without success, culminating with death. After authorization of the owner, necropsy was performed.…”

Section: Casementioning

confidence: 99%

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Renal Dysplasia in a Maltese dog

Cruz¹,

Silva²,

Silva³

et al. 2019

Acta Scientiae. Vet.

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Background: Renal dysplasia (RD) is a common cause of renal failure in young dogs. It is defined as a disorganization in renal parenchymal development, with abnormal differentiation. In all domestic animal species, RD may be hereditary or acquired. The affected animals show clinical signs of early chronic kidney disease, usually between 3 months to 3 years of age. The alterations include persistent metanephric ducts surrounded by primitive mesenchyme, glomeruli and fetal tubules, and abnormal interstitial fibrous tissue. We aimed to report the case of a 1-year-old canine with renal dysplasia. Case: A 1-year-old male Maltese dog experiencing polyuria, polydipsia, recurrent episodic vomiting, bloody diarrhea, weight loss, apathy, and anorexia was referred to a private clinic in the municipality of Itabuna-Bahia. Physical examination revealed hypochromic mucosa, dehydration estimated at 8%, rectal temperature of 37.5ºC, halitosis, and a body score of 3 out of 9. Laboratory abnormalities included hematocrit of 18%, with hypochromic normocytic aregenerative anemia, azotemia (urea -530 mg/dL, creatinine -10.5 mg/dL), hyperglobulinemia (4.7 g/dL), low urinary density (1005), proteinuria (300 mg/dL), and urinary pH -7.0. Ultrasonography revealed bilateral small kidneys with loss of corticomedullary definition, cystic formations of different sizes on the renal surface, and hyperechoic areas in the parenchyma; these alterations were suggestive of bilateral chronic nephropathy. Considering the clinical, hematological, biochemical, and ultrasonographic presentation associated with the age of the patient, renal dysplasia was suspected. The patient's clinical condition progressed to loss of consciousness and convulsions, followed by death. Necropsy revealed pale, hypotrophic kidneys with firm consistency, irregular capsular surface containing multiple cortical cysts of different sizes, and altered cortico-medullar proportion.. Kidney fragments were sent to the Laboratory of Histopathology of the State University of Santa Cruz. Histopathological analysis revealed a marked alteration of renal architecture with glomeruli and immature tubules (adenomatous aspect), persistent primitive mesenchyme, and remnants of the metanephric ducts, as well as tubular dilatation associated with marked interstitial fibrosis, discrete lymphohistiocytic interstitial nephritis, and multifocal areas of mineralization. Discussion: The clinical changes observed in the present case occurred as a consequence of chronic kidney failure caused by RD and included anorexia, apathy, vomiting, bloody diarrhea, polyuria, polydipsia, and dehydration. These alterations were also found in other reported cases. The macroscopic findings were similar to those described in the literature and are characteristic of chronic kidney disease: small, firm, pale-colored kidneys. Microscopic changes of renal dysplasia include persistent metanephric ducts surrounded by primitive mesenchyme, glomeruli and fetal tubules, and abnormal interstitial fibrous tissue. In the histopathol...

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Section: Discussionmentioning

confidence: 97%

Section: Casementioning

confidence: 99%

Renal Dysplasia in a Maltese dog

Cruz¹,

Silva²,

Silva³

et al. 2019

Acta Scientiae. Vet.

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“…Os exames laboratoriais revelaram uma anemia arregenerativa e creatinina elevada. A Anemia arregenerativa ocorre devido à baixa produção de eritropoetina por um rim afetado pela enfermidade (HUNNING, ET AL, 2009).…”

Section: Métodosunclassified

Displasia renal em cão - relato de caso

2022

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A displasia renal é uma doença hereditária ou congênita causadora de nefropatia crônica em indivíduos jovens. Os sinais clínicos relacionam – se a insuficiência renal crônica e incluem anorexia, letárgia, poliúria, vômitos intensos e emagrecimento. O diagnóstico é realizado por meio de exames laboratoriais e de imagem. O tratamento é geralmente, conservativo e sintomático. O prognóstico depende da gravidade da displasia. Contudo, geralmente o animal vem a óbito em alguns meses. O objetivo desse trabalho foi relatar o caso clínico de um paciente canino, macho, da raça American Bully, não castrado, de sete meses que foi diagnosticado com displasia renal.

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“…A displasia renal é um distúrbio congênito que ocorre durante a diferenciação do parênquima renal ou como resultado secundário de uma obstrução funcional e/ou estrutural do trato urinário inferior [18] e a sua severidade depende da quantidade de néfrons imaturos [1]. Em estágio avançado, o animal pode apresentar sinais clínicos e ultrassonográficos semelhantes aos de doenças renais crônicas [19,20], como polidipsia, poliúria, vômito, desidratação, anemia [7], azotemia, hiperfosfatemia e anemia arregenerativa, baixa densidade urinária e ausência de proteinúria [1,6].…”

Section: Introductionunclassified

Renal Dysplasia in a Free-Living Giant Anteater Cub (Myrmecophaga tridactyla) - Ultrasonographic and Tomographic Aspects

Jaworski

Borba

Rezende

et al. 2021

Acta Scientiae. Vet.

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Background: Renal dysplasia is a congenital disorder that occurs during differentiation of the renal parenchyma or as a consequence of a functional and/or structural obstruction of the lower urinary tract. In wild animals, this pathology has been reported in cynomolgus monkeys (Macaca fascicularis), golden hamsters (Mesocricetus auratus) and African elephants (Loxodanta africana). However, there are no reports of the disease in the giant anteater (Myrmecophaga tridactyla). Thus, this paper describes a case of renal dysplasia in a free-living giant anteater cub, which was sent to the wild animal clinic of the Federal University of Mato Grosso (UFMT) in Cuiabá, MT, Brazil. Case: The rescued animal had a good body condition score and clinical parameters within the normal range for the species. After a routine clinical evaluation, the anteater cub was subjected to radiography and ultrasound tests. Blood tests, serum tests for hepatic and renal profiles, urinalysis, urinary protein creatinine ratio, and chest X-rays did not reveal significant changes. However, the abdominal ultrasound examination revealed a volumetric loss of about 1.17 cm in length in the left kidney, and a renal length to aortic artery diameter ratio of approximately 2.8. This kidney showed irregular contours, loss of corticomedullary demarcation, with preserved echogenicity and cortical echotexture. The right kidney showed the standard size of the species, with a length of approximately 3.08 cm. In view of the suspicion of renal dysplasia, a contrast-enhanced CT scan was performed in order to assess the dynamics of uptake and excretion of the contrast medium in the affected kidney and in the ipsilateral collecting system. An examination of the tomographic images indicated that the volume of the left kidney was reduced, isodense in relation to the right kidney, with discrete and homogeneous uptake in all phases after administration of the contrast medium, no occurrence of nephrogram and pyelogram phases, or any detection of contrast in the corresponding ureter.Discussion: Giant anteaters (Myrmecophaga tridactyla) are animals classified as a species vulnerable to extinction. Today, most research involving this species focuses on its ecology, behavior, diet, morphology and parasitology, but little is known about the imaging aspects of the species or about congenital changes such as renal dysplasia. Although the definitive diagnosis of this pathology depends on a histopathological examination, the same diagnosis can be made with a wide margin of safety by assessing the epidemiological aspects and the dynamics of renal uptake of the contrast medium through computed tomography. In this analysis, both vascularization and renal filtration capacity can be assessed. Thus, based on CT imaging, it was concluded that this was a case of renal dysplasia, since the left kidney showed a discrete homogeneous uptake stable in both the arterial and venous phases, without producing any accumulation of contrast medium in the pelvic region or the collecting system, proving to be completely nonfunctional. These findings differ from cases of renal hypoplasia, which, although they reduce renal volume, do not cause structural changes in the renal parenchyma or disturbances in the filtration dynamics of contrast media. They also differ from cases of acquired chronic nephropathy, since, albeit associated with reduced renal volume and changes in renal filtration dynamics, they produce different parenchymal ultrasound changes that usually occur in elderly animals and generally produce bilateral lesions.

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Displasia renal em um cão

Cited by 5 publications

References 5 publications

Renal Dysplasia in a Maltese dog

Renal Dysplasia in a Maltese dog

Displasia renal em cão - relato de caso

Renal Dysplasia in a Free-Living Giant Anteater Cub (Myrmecophaga tridactyla) - Ultrasonographic and Tomographic Aspects

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