1999
DOI: 10.1021/ac9907686
|View full text |Cite
|
Sign up to set email alerts
|

Disposable Optical Sensor Chip for Medical Diagnostics:  New Ways in Bioanalysis

Abstract: An optical sensor system is described which is particularly well suited for medical point-of-care diagnostics. The system allows for all kinds of immunochemical assay formats and consists of a disposable sensor chip and an optical readout device. The chip is built up from a ground and cover plate with in- and outlet and, between, of an adhesive film with a capillary aperture of 50 microns. The ground plate serves as a solid phase for the immobilization of biocomponents. In the readout device, an evanescent fie… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
56
0
1

Year Published

2001
2001
2017
2017

Publication Types

Select...
8
1
1

Relationship

0
10

Authors

Journals

citations
Cited by 91 publications
(57 citation statements)
references
References 26 publications
0
56
0
1
Order By: Relevance
“…It is further unique to the presented approach that the resulting nanowaveguide structures are free-standing and can be easily detached from the substrate. Eventually, the fabrication scheme was used to produce LiNbO 3 nanowaveguides that have been successfully tested optically and clearly showed efficient SHG [24]. In terms of size, free-standing geometry, and due to the sufficiently large frequency conversion efficiency, these waveguides can be understood as counterparts to chemically synthesized nanowires [34,50,51].…”
Section: Resultsmentioning
confidence: 99%
“…It is further unique to the presented approach that the resulting nanowaveguide structures are free-standing and can be easily detached from the substrate. Eventually, the fabrication scheme was used to produce LiNbO 3 nanowaveguides that have been successfully tested optically and clearly showed efficient SHG [24]. In terms of size, free-standing geometry, and due to the sufficiently large frequency conversion efficiency, these waveguides can be understood as counterparts to chemically synthesized nanowires [34,50,51].…”
Section: Resultsmentioning
confidence: 99%
“…It has a maximum intensity at the surface, which is reduced with increasing distance from the surface [92]. These sensors demonstrate high sensitivity and can avoid separation and extraction steps from complex matrices such as body fluids [93,94]. As an example, studies were carried out using TIRF immunosensors to evaluate the concentration of bovine progesterone, a reproductive hormone present in raw milk [95,96].…”
Section: Indirect Optical Detectionmentioning
confidence: 99%
“…Based on TIR, disposable plastic prisms integrated on biochips [61] with several different types of evanescent waveguides, including fiber [62], channel [63], and planar [64,65] waveguides, have been proposed to address the requirements for ultra-sensitive, high-throughput platforms. In all of these systems, the excitation laser beam comes from the side of the chip, which requires highly precise aligned at a specified angle to achieve efficient light coupling and to create a strong evanescent field.…”
Section: Minaturized Total Internal Reflection (Mtir) Systemmentioning
confidence: 99%