Disposable oxygen electrodes fabricated by semiconductor techniques and their application to biosensors

Suzuki, Hiroaki; Kojima, Naomi; Sugama, Atsushi; Takei, Fumio; Ikegami, Kasumi

doi:10.1016/0925-4005(90)80266-3

Cited by 16 publications

(8 citation statements)

References 3 publications

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“…In the present fabrication, the oxygen-permeable membrane below the PDMS container readily and strongly adhered to the glass substrate due to the PDMS container-glass bonding. This greatly reduced the failure ratio which is usually high in dip-or spin-coating fabrication [3][4][5][6]8,9]. Fig.…”

Section: Fabrication Of Miniature Clark Oxygen Sensormentioning

confidence: 97%

“…Additionally, the adhesion force of the oxygen-permeable membrane to the electrode surface also affects the durability of miniature Clark sensors. Generally, the membrane is immobilized with a physical adhesion force using dipping [4][5][6]8], spinning [3,9], casting [10], or glue-assisted techniques [2]. In the present fabrication, the oxygen-permeable membrane below the PDMS container readily and strongly adhered to the glass substrate due to the PDMS container-glass bonding.…”

Section: Fabrication Of Miniature Clark Oxygen Sensormentioning

confidence: 98%

“…It is necessary to consider the following aspects for fabricating a reliable sensor: (1) the fabrication and configuration of electrochemical electrodes in order to reduce the electrochemical crosstalk between different electrodes, (2) miniaturization techniques of the reference electrode for a longer lifetime and a more stable potential, (3) fixation and characteristics of internal electrolyte using different hydrogels or various types of electrolytes, and (4) bonding strategies and durability of the oxygen-permeable membrane and the detector substrate. Suzuki and coworkers have significantly improved the above aspects [3][4][5][6][7][8][9][10][11] and employed the sensors practically in biological measurements [12][13][14].…”

Section: Introductionmentioning

confidence: 98%

“…Among the various tools to determine oxygen, the Clark-type oxygen sensor is the most widely used and has been applied in clinical analysis, fermentation monitoring, and biosensor development [1]. In the past two decades, owing to the progress in semiconductor and micromachining techniques, various types of miniature Clark-type oxygen sensors have been proposed [2][3][4][5][6][7][8][9][10][11][12]. It is necessary to consider the following aspects for fabricating a reliable sensor: (1) the fabrication and configuration of electrochemical electrodes in order to reduce the electrochemical crosstalk between different electrodes, (2) miniaturization techniques of the reference electrode for a longer lifetime and a more stable potential, (3) fixation and characteristics of internal electrolyte using different hydrogels or various types of electrolytes, and (4) bonding strategies and durability of the oxygen-permeable membrane and the detector substrate.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of miniature Clark oxygen sensor integrated with microstructure

Yasukawa

Shiku

et al. 2005

Sensors and Actuators B: Chemical

101

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Section: Fabrication Of Miniature Clark Oxygen Sensormentioning

confidence: 97%

Section: Fabrication Of Miniature Clark Oxygen Sensormentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fabrication of miniature Clark oxygen sensor integrated with microstructure

Yasukawa

Shiku

et al. 2005

Sensors and Actuators B: Chemical

101

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“…With the advent of microfabrication, miniaturized planar O 2 electrodes have been produced. In one example, Suzuki et al (1990) produced a 350 µm deep silicon structure with anisotropically etched v-grooves, which contained electrolytes and the surfaces of which included a cathode (working electrode) and an anode. This internal micro-reaction chamber for the polarographic reduction of O 2 was bounded by a gas-permeable membrane based on a negative photoresist.…”

Section: Electrochemical O 2 Monitoringmentioning

confidence: 99%

O₂microsensors for minimally invasive tissue monitoring

Wang

Vadgama

2004

J. R. Soc. Interface.

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Tissue oxygenation is a key factor ensuring normal tissue functions and viability. Continuous real-time monitoring of the partial pressure of oxygen, pO 2 , in tissues gives insight into the dynamic fluctuations of O 2 supplies to tissues by blood circulation. Small oxygen sensors enable investigations of the spatial variation of pO 2 in tissues at different locations in relation to local microvessels. In this paper, pO 2 measurement using microelectrodes and biocompatible sensors is discussed and recent progress of their application in human skin is reviewed. Emphasis is given to working principles of a number of existing oxygen sensors and their potential application in vivo and in tissue engineering. Results on spatial and temporal variations of the pO 2 in human skin introduced by localized ischaemia-reperfusion are presented when the surface of the skin is covered by an oxygen-free paraffin oil layer and the range of the tissue pO 2 is deduced to be between 0 and 60 mmHg. In the study, pO 2 increases from 8.0 ± 3.2 mmHg (n = 6) at the surface of the skin to 35.2 ± 8.0 mmHg (n = 9) at a depth just above the subpapillary plexus. Temporal decay in pO 2 following tissue compression and rise in pO 2 following pressure release can be described using mono-exponential functions. The time constant for the exponential decay, τ = 8.44 ± 1.53 s (n = 7) is consistently greater than that for the exponential rises, τ = 4.75 ± 0.82 s (n = 6). The difference in pO 2 change with the time following tissue compression and pressure release reveals different dynamic mechanisms involved in the two transient phases. The elevated steady state pO 2 following reperfusion, which is approximately 20% higher than the pre-occlusion value, indicates localized reactive hyperaemia. Possible applications of O 2 microsensors in diseases, e.g. tumours, pressure ulcers, are also discussed.

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Chemical and Biochemical Sensors

Cammann¹,

Roß²,

Katerkamp³

et al. 2001

Ullmann's Encyclopedia of Industrial Chemistry

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The article contains sections titled: 1. Introduction to the Field of Sensors and Actuators 2. Chemical Sensors 2.1. Introduction 2.2. Molecular Recognition Processes and Corresponding Selectivities 2.2.1. Catalytic Processes in Calorimetric Devices 2.2.2. Reactions at Semiconductor Surfaces and Interfaces Influencing Surface or Bulk Conductivities 2.2.3. Selective Ion Conductivities in Solid‐State Materials 2.2.4. Selective Adsorption ‐ Distribution and Supramolecular Chemistry at Interfaces 2.2.5. Selective Charge‐Transfer Processes at Ion‐Selective Electrodes (Potentiometry) 2.2.6. Selective Electrochemical Reactions at Working Electrodes (Voltammetry and Amperometry) 2.2.7. Molecular Recognition Processes Based on Molecular Biological Principles 2.3. Transducers for Molecular Recognition: Processes and Sensitivities 2.3.1. Electrochemical Sensors 2.3.1.1. Self‐Indicating Potentiometric Electrodes 2.3.1.2. Voltammetric and Amperometric Cells 2.3.1.3. Conductance Devices 2.3.1.4. Ion‐Selective Field‐Effect Transistors (ISFETs) 2.3.2. Optical Sensors 2.3.2.1. Fiber‐Optical Sensors 2.3.2.2. Integrated Optical Chemical and Biochemical Sensors 2.3.2.3. Surface Plasmon Resonance 2.3.2.4. Reflectometric Interference Spectroscopy 2.3.3. Mass‐Sensitive Devices 2.3.3.1. Introduction 2.3.3.2. Fundamental Principles and Basic Types of Transducers 2.3.3.3. Theoretical Background 2.3.3.4. Technical Considerations 2.3.3.5. Specific Applications 2.3.3.6. Conclusions and Outlook 2.3.4. Calorimetric Devices 2.4. Problems Associated with Chemical Sensors 2.5. Multisensor Arrays, Electronic Noses, and Tongues 3. Biochemical Sensors (Biosensors) 3.1. Definitions, General Construction, and Classification 3.2. Biocatalytic (Metabolic) Sensors 3.2.1. Monoenzyme Sensors 3.2.2. Multienzyme Sensors 3.2.3. Enzyme Sensors for Inhibitors ‐ Toxic Effect Sensors 3.2.4. Biosensors Utilizing Intact Biological Receptors 3.3. Affinity Sensors ‐ Immuno‐Probes 3.3.1. Direct‐Sensing Immuno‐Probes without Marker Molecules 3.3.2. Indirect‐Sensing Immuno‐Probes using Marker Molecules 3.4. Whole‐Cell Biosensors 3.5. Problems and Future Prospects 4. Actuators and Instrumentation 5. Future Trends and Outlook

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Disposable oxygen electrodes fabricated by semiconductor techniques and their application to biosensors

Cited by 16 publications

References 3 publications

Fabrication of miniature Clark oxygen sensor integrated with microstructure

Fabrication of miniature Clark oxygen sensor integrated with microstructure

O₂microsensors for minimally invasive tissue monitoring

Chemical and Biochemical Sensors

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Disposable oxygen electrodes fabricated by semiconductor techniques and their application to biosensors

Cited by 16 publications

References 3 publications

Fabrication of miniature Clark oxygen sensor integrated with microstructure

Fabrication of miniature Clark oxygen sensor integrated with microstructure

O2microsensors for minimally invasive tissue monitoring

Chemical and Biochemical Sensors

Contact Info

Product

Resources

About

O₂microsensors for minimally invasive tissue monitoring