Disposable silicon-glass microfluidic devices: precise, robust and cheap

Qi, ZhenBang; Xu, Lining; Xu, Yi; Zhong, Junjie; Abedini, Ali; Cheng, Xiang

doi:10.1039/c8lc01109e

Cited by 56 publications

(35 citation statements)

References 58 publications

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“…Silicon-based devices have also been used and have many of the same benefits as glass. ,, Silicon, however, is not optically clear, and thus a portion of the device must be nonsilicon for in situ imaging. Additionally, silicon has been widely used in the fabrication of electronics, and techniques for fabricating silicon-based platforms, including dry or wet etching, laser-drilling, sand-blasting, and direct, anodic, or adhesive bonding, are well established .…”

Section: Pdms Alternatives For Device Fabricationmentioning

confidence: 99%

“…Additionally, silicon has been widely used in the fabrication of electronics, and techniques for fabricating silicon-based platforms, including dry or wet etching, laser-drilling, sand-blasting, and direct, anodic, or adhesive bonding, are well established . Silicon-glass microfluidic devices have been reported that are disposable, inexpensive (close to $5 USD), and can be rapidly fabricated for high-throughput experiments to address the main disadvantages of glass; however, such combined silicon-glass devices have yet to be widely utilized within MPS applications.…”

Section: Pdms Alternatives For Device Fabricationmentioning

confidence: 99%

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Beyond Polydimethylsiloxane: Alternative Materials for Fabrication of Organ-on-a-Chip Devices and Microphysiological Systems

Campbell

Yazbeck

et al. 2020

ACS Biomater. Sci. Eng.

190

175

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Polydimethylsiloxane (PDMS) is the predominant material used for organ-on-a-chip devices and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical transparency, and inexpensive microfabrication. However, the absorption of small hydrophobic molecules by PDMS and the limited capacity for high-throughput manufacturing of PDMS-laden devices severely limit the application of these systems in personalized medicine, drug discovery, in vitro pharmacokinetic/pharmacodynamic (PK/PD) modeling, and the investigation of cellular responses to drugs. Consequently, the relatively young field of organ-on-a-chip devices and MPSs is gradually beginning to make the transition to alternative, nonabsorptive materials for these crucial applications. This review examines some of the first steps that have been made in the development of organ-on-a-chip devices and MPSs composed of such alternative materials, including elastomers, hydrogels, thermoplastic polymers, and inorganic materials. It also provides an outlook on where PDMS-alternative devices are trending and the obstacles that must be overcome in the development of versatile devices based on alternative materials to PDMS.

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Section: Pdms Alternatives For Device Fabricationmentioning

confidence: 99%

Section: Pdms Alternatives For Device Fabricationmentioning

confidence: 99%

Beyond Polydimethylsiloxane: Alternative Materials for Fabrication of Organ-on-a-Chip Devices and Microphysiological Systems

Campbell

Yazbeck

et al. 2020

ACS Biomater. Sci. Eng.

190

175

View full text Add to dashboard Cite

show abstract

“…These two PLL-ZID macromolecules were first synthesized and characterized in solution (by techniques including NMR, DOSY and IR) prior to surface immobilization. In this study, silicon oxide was used as a model substrate because of its relevance in, e.g., biosensors [46] and microfluidic devices [47]. After self-assembly on silicon oxide surfaces, the formed coatings were investigated using water contact angle (WCA) measurements and X-ray photoelectron spectroscopy (XPS).…”

Section: Introductionmentioning

confidence: 99%

Zwitterionic dendrimer – Polymer hybrid copolymers for self-assembling antifouling coatings

Roeven

Scheres²,

Smulders

et al. 2021

European Polymer Journal

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“…In this study, silicon oxide was used as a model substrate because of its relevance in, e.g., biosensors 44 and microfluidic devices. 45 We explored three different routes toward such a coating with varying degrees of grafting-to and grafting-from components ( Figure 1 ). Route A: a coating was completely grafted from the surface.…”

Section: Introductionmentioning

confidence: 99%

PLL–Poly(HPMA) Bottlebrush-Based Antifouling Coatings: Three Grafting Routes

Roeven

Kuzmyn

Scheres³

et al. 2020

Langmuir

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In this work, we compare three routes to prepare antifouling coatings that consist of poly( l -lysine)–poly( N -(2-hydroxypropyl)methacrylamide) bottlebrushes. The poly( l -lysine) (PLL) backbone is self-assembled onto the surface by charged-based interactions between the lysine groups and the negatively charged silicon oxide surface, whereas the poly( N -(2-hydroxypropyl)methacrylamide) [poly(HPMA)] side chains, grown by reversible addition–fragmentation chain-transfer (RAFT) polymerization, provide antifouling properties to the surface. First, the PLL–poly(HPMA) coatings are synthesized in a bottom-up fashion through a grafting-from approach. In this route, the PLL is self-assembled onto a surface, after which a polymerization agent is immobilized, and finally HPMA is polymerized from the surface. In the second explored route, the PLL is modified in solution by a RAFT agent to create a macroinitiator. After self-assembly of this macroinitiator onto the surface, poly(HPMA) is polymerized from the surface by RAFT. In the third and last route, the whole PLL–poly(HPMA) bottlebrush is initially synthesized in solution. To this end, HPMA is polymerized from the macroinitiator in solution and the PLL–poly(HPMA) bottlebrush is then self-assembled onto the surface in just one step ( grafting-to approach). Additionally, in this third route, we also design and synthesize a bottlebrush polymer with a PLL backbone and poly(HPMA) side chains, with the latter containing 5% carboxybetaine (CB) monomers that eventually allow for additional (bio)functionalization in solution or after surface immobilization. These three routes are evaluated in terms of ease of synthesis, scalability, ease of characterization, and a preliminary investigation of their antifouling performance. All three coating procedures result in coatings that show antifouling properties in single-protein antifouling tests. This method thus presents a new, simple, versatile, and highly scalable approach for the manufacturing of PLL-based bottlebrush coatings that can be synthesized partly or completely on the surface or in solution, depending on the desired production process and/or application.

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Disposable silicon-glass microfluidic devices: precise, robust and cheap

Abstract: We developed a method for reducing the cost of Si-glass microfluidic chips while maintaining the precision and robustness unique to Si-glass system.

Cited by 56 publications

References 58 publications

Beyond Polydimethylsiloxane: Alternative Materials for Fabrication of Organ-on-a-Chip Devices and Microphysiological Systems

Beyond Polydimethylsiloxane: Alternative Materials for Fabrication of Organ-on-a-Chip Devices and Microphysiological Systems

Zwitterionic dendrimer – Polymer hybrid copolymers for self-assembling antifouling coatings

PLL–Poly(HPMA) Bottlebrush-Based Antifouling Coatings: Three Grafting Routes

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