Disposable solid state probe for optical screening of chlorpromazine

Guerreiro, J. Rafaela L.; Sales, M. Goreti F.

doi:10.1007/s00604-011-0671-7

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…As far as we know, there are only two colored sensing strips available in the literature for detecting drugs in aquatic environment, both devoted to Quinolone antibiotics (Lara Guerreiro and Ferreira Sales, 2011;Silva et al, 2012). These strips consisted of plasticized PVC entrapping a suitable reagent, with which the antibiotic would form a colored complex.…”

Section: Introductionmentioning

confidence: 99%

Development of paper-based color test-strip for drug detection in aquatic environment: Application to oxytetracycline

Gomes

Sales

2015

Biosensors and Bioelectronics

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The wide use of antibiotics in aquaculture has led to the emergence of resistant microbial species. It should be avoided/minimized by controlling the amount of drug employed in fish farming. For this purpose, the present work proposes test-strip papers aiming at the detection/semi-quantitative determination of organic drugs by visual comparison of color changes, in a similar analytical procedure to that of pH monitoring by universal pH paper. This is done by establishing suitable chemical changes upon cellulose, attributing the paper the ability to react with the organic drug and to produce a color change. Quantitative data is also enabled by taking a picture and applying a suitable mathematical treatment to the color coordinates given by the HSL system used by windows.As proof of concept, this approach was applied to oxytetracycline (OXY), one of the antibiotics frequently used in aquaculture. A bottom-up modification of paper was established, starting by the reaction of the glucose moieties on the paper with 3-triethoxysilylpropylamine (APTES). The so-formed amine layer allowed binding to a metal ion by coordination chemistry, while the metal ion reacted after with the drug to produce a colored compound. The most suitable metals to carry out such modification were selected by bulk studies, and the several stages of the paper modification were optimized to produce an intense color change against the concentration of the drug. The paper strips were applied to the analysis of spiked environmental water, allowing a quantitative determination for OXY concentra-tions as low as 30 ng/mL. In general, this work provided a simple, method to screen and discriminate tetracycline drugs, in aquaculture, being a promising tool for local, quick and cheap monitoring of drugs.

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Section: Introductionmentioning

confidence: 99%

Development of paper-based color test-strip for drug detection in aquatic environment: Application to oxytetracycline

Gomes

Sales

2015

Biosensors and Bioelectronics

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“…As far as we know, very few methods report the development of test-strips for antibiotics, which are equipmentfree methods. This includes plasticized PVC strips, in which the incubation of a given antibiotic lead to a given colour, yielding semi-quantitative data by comparing with a standard colour palette [41,42]. These works involved a colourimetric reaction between a target antibiotic and a suitable reagent, entrapped within a plasticized PVC support.…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

A cellulose-based colour test-strip for equipment-free drug detection on-site: application to sulfadiazine in aquatic environment

Teixeira

Sales

2020

SN Appl. Sci.

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This work develops a simple and innovative test-strip to monitor antibiotics in aquaculture facilities by an equipment-free approach. It consists of a low-cost disposable cellulose paper that was chemically modified to produce a colour change when in contact with a given antibiotic. In brief, the cellulose substrate was subject to oxidation with periodate, followed by amination with chitosan binding and modification with Cu(II). The test strip was then dipped in the target solution and the intensity of the colour generated therein revealed the concentration of antibiotic present for concentrations higher than 0.5 mM. The higher the concentration in sulfadiazine (SDZ), the more intense the pink colour formed in the final solution, which was also turbid due to the insolubility of the formed product. This colour intensity also varied linearly with the logarithm of the SDZ concentration (from 0.5 to 5 mM), when plotted against the sum of the RGB coordinates extracted from digital pictures. The linear equation of this response was represented by (R + G + B) = − 256.1 log(SDZ, mol/L) − 362.0, with an R-squared of 0.9913. The test-strip was stable for at least 15 days and was selective in the presence of tetracycline and difloxacin, while the response to other members of the sulfadiazine family requires prior evaluation. Overall, the test-strips developed herein are inexpensive and provide valuable (semi-) quantitative data for monitoring SDZ in waters, a most valuable approach to control and reduce the level of antibiotics in fish tanks, which in turn may reduce the costs of fish production and the environmental concerns linked to this practice. Moreover, the test strip uses a cellulose substrate that has little environmental impact upon discard.

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“…It has distinct diffraction wavelength which causes its specific structural color. When the PC is exposed to physical or chemical stimuli, its diffraction wavelength or intensities will be changed. , Thus, it has attracted much interest for application in in vitro diagnosis, − food safety, − and environmental monitoring. − The recognition groups attached to the PC are the key to achieve specific detection. The chemical reaction between specific recognition groups and targets is regarded as an alternative choice.…”

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confidence: 99%

Michael-Addition-Mediated Photonic Crystals Allow Pretreatment-Free and Label-Free Sensoring of Ciprofloxacin in Fish Farming Water

Song

Bai²,

Zhang³

et al. 2017

Anal. Chem.

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Abuse of antibiotics results in a large number of antibiotics residues in the environment and even causes the problem of "super bacteria". Therefore, it is crucial to develop a powerful analytic method to monitor antibiotics quickly and simply. Photonic crystal (PC), as a sensing material, has promising application prospects. Herein, we try to use PC to realize pretreatment-free and label-free detection of Ciprofloxacin (CF) through Michael addition reaction. The recognition process is carried out by the Michael addition reaction between the piperazine group of CF and the o-benzoquinone group on the PC. The monodisperse microspheres with o-benzoquinone groups are prepared by polymerization and oxidation and then stacked to form PC. During the detection, the peak intensity of the PC decreases with the increasing CF concentration, and the linear range is from 2 to 512 μg/L. The limit of detection (LOD) is 0.76 μg/L. Furthermore, the PC retains 97% of the initial response after storage in a Petri dish at room temperature for 1 month, which shows that it has good stability. Moreover, CF in fish farming water can be detected directly without any pretreatment and label, and the results are in good accordance with the LC-MS-MS results. This Michael-addition-mediated PC is accurate, easily prepared, cost-efficient, and long-term stable. In addition, it is environmentally friendly, because little organic solvent is needed during both the preparation and the detection.

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Disposable solid state probe for optical screening of chlorpromazine

Cited by 7 publications

References 26 publications

Development of paper-based color test-strip for drug detection in aquatic environment: Application to oxytetracycline

Development of paper-based color test-strip for drug detection in aquatic environment: Application to oxytetracycline

A cellulose-based colour test-strip for equipment-free drug detection on-site: application to sulfadiazine in aquatic environment

Michael-Addition-Mediated Photonic Crystals Allow Pretreatment-Free and Label-Free Sensoring of Ciprofloxacin in Fish Farming Water

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