With the continuous development of nuclear energy, the spent fuel produced by the decay of radionuclides also increases. How to ensure environmental safety through safe transportation management and effective disposal of spent fuel is a new social proposition that needs to be considered and discussed in environmental protection. Based on the Web of Science database, the bibliometric tool Histcite is used to carry out a systematic metrological analysis of the research on spent fuel transportation, compares the status and priorities of spent fuel transportation research at home and abroad, grasps the current research trends and hot issues, and analyzes the development status of spent fuel transportation safety based on trend analysis. The research results show that the research related to spent fuel transportation first started in 1972 and the number of documents is increasing; the M-K trend test analysis results also show that there are obvious mutations in the related research. The internationally influential units in the field of spent fuel transportation are mainly concentrated in European and American countries such as the United States and Sweden, and the quality of the literature is high, and they are in an international leading position. The whole process of transportation assessment and environmental risk simulation are the research hotspots in this field.