Disposition kinetics of 7,12‐dimethylbenz(a)anthracene in rats

Niazi, Sarfaraz K.; Hussain, M M

doi:10.1002/bdd.2510130805

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…меченый канцероген вводили крысам-матерям внутрибрюшинно однократно на 21 дне беременности в виде водно-липидной эмульсии в дозе 15 мг/кг в расчете на ДмБа. Эта доза являлась наиболее оптимальной для индукции опухолей мозга и почек у потомства, так как кинетические показатели клиренса и периода полужизни введенного ДмБа незначительно различались от таковых, при введении канцерогена в диапазоне от 5 до 50 мг/кг [11].…”

Section: материалы и методыunclassified

“…С появлением новых методов секвенирования и успехами транскрипционного анализа было выявлено, что до 70% экспрессируемой рнК используется не в качестве матриц для синтеза белка, а принимают участие в активации или подавлении экспрессии генов, в том числе, в связи с процессами онкогенеза [1,7,13]. Это показано для ткани печени [11], почек [4] и головного мозга [10]. Следовательно, наблюдавшееся нами увеличение связывания метки из 3 н-ДмБа с рнК отражало в значительной степени специфическое образование канцерогенных аддуктов с регуляторными рибонуклеотидами, что в сочетании с активной пролиферацией может обусловить таргетную инициацию канцерогенеза.…”

Section: радиоактивные аддукты дмба в нуклеиновых кислотах тканей мат...unclassified

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Binding of 3h-Dmba With Biopolymers of Mother and Fetus Tissues in Rats During Transplacental Carcinogenesis

Ivanov¹,

Aleksandrov²,

Semenov³

et al. 2018

Problems in oncology

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The aim of the study was to establish regularities of activated 3H-7,12-dimetilbenz(a)antratcene (DMBA) translocation in the major biopolymers of target and non-target organs at the initiation stage of transplacental carcinogenesis. DMBA was administered i.p. to rats on the 21th day of the pregnancy. Analysis of liver and kidney tissues of mothers, as well as liver, kidney, and brain of offspring was performed at temporal points of 1 hr to 14 days after single carcinogen administration. A regular, but transient non-specific accumulation of DMBA-radioactivity in the lipid fraction mainly embryonic tissues was observed during the first 6 hrs after administration of the labeled carcinogen. By 6 hrs, the maximum increase of label in RNA of embryonic brain and kidney (target organ for tumor induction) was observed and then, from 6 to 12 hrs, an increase occurred in the number of radioactive DNA adducts of fetus that was maintained for 24 hrs in these tissues. Increased accumulation of label in proteins of embryonic kidney was recorded from 6 to 24 hrs, and brain - from 12 to 24 hrs after administration of 3H-DMBA and on the 7th day in proteins of these organs of newborn rats.

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Section: материалы и методыunclassified

Section: радиоактивные аддукты дмба в нуклеиновых кислотах тканей мат...unclassified

Binding of 3h-Dmba With Biopolymers of Mother and Fetus Tissues in Rats During Transplacental Carcinogenesis

Ivanov¹,

Aleksandrov²,

Semenov³

et al. 2018

Problems in oncology

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Animal models of breast cancer: experimental design and their use in nutrition and psychosocial research

Clarke

1997

Breast Cancer Res Treat

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This is the second Special Issue addressing the diversity and use of animal models of breast cancer. The previous issue (Breast Cancer Res Treat 39:1-135, 1996), dealt with a variety of topics such as the characteristics of chemically- and virally-induced rodent models, immunobiologies of immunedeficient mice, transgenic mouse models, and models of metastasis. In the first part of this second Special Issue, the articles address animal models for studying life-style factors, including psychosocial, exercise, and nutritional research in breast cancer. In the second section, there is emphasis on the controversial area of dietary fat, with other authors addressing caloric restriction and dietary isoflavonoids, retinoids, and monoterpenes in the third part. In the final section, a series of authors provide suggestions for approaching various issues involving experimental design, including nutritional studies, drug screening models, statistical considerations, quantitation of tumor growth kinetics, and animal husbandry. These articles, and some additional issues raised during the previous Special Issue, are briefly discussed in this overview. They include a further evaluation of the relative merits of 7,12-dimethylbenz(a)anthracene and N-nitroso-N-methylurea as carcinogens, and of the use of the AIN76 and AIN93 semipurified diets in studies of mammary carcinogenesis.

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Disposition kinetics of 7,12‐dimethylbenz(a)anthracene in rats

Cited by 2 publications

References 17 publications

Binding of 3h-Dmba With Biopolymers of Mother and Fetus Tissues in Rats During Transplacental Carcinogenesis

Binding of 3h-Dmba With Biopolymers of Mother and Fetus Tissues in Rats During Transplacental Carcinogenesis

Animal models of breast cancer: experimental design and their use in nutrition and psychosocial research

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