Disposition of sucrose octa-isobutyrate in rats, dogs and monkeys

Safety Assessment of Saccharide Esters as Used in Cosmetics

“…52 In dogs, Sucrose Octaisobutyrate was slowly absorbed, with less extensive hydrolysis in the gut, as compared to rats; in monkeys it was not absorbed or hydrolyzed in the gut. 52…”

“…In oral studies in rats, Glucose Pentaacetate (20% aqueous solution, no radioactive label used) was rapidly absorbed (> 90% in 4 hours), 50 and excretion occurred mostly in the feces after administration of a [ 14 C]Sucrose Palmitate and Sucrose Stearate mixture (details on radiolabeling are specified in Table 9) 48 ; a mixture of sucrose esters (250 mg/kg, radiolabels on either sucrose or ester portion, see Table 9 for details), including Sucrose Hexastearate, was hydrolyzed prior to intestinal absorption (less esterified compounds were better absorbed) and largely excreted in feces (>96%-99% of radioactivity) at 120 hours postdosing 51 ; and 200 mg/kg of Sucrose Octaisobutyrate (a component of Sucrose Acetate Isobutyrate, 14 C label on sucrose) was excreted in feces (78%-93% of dosed radioactivity), excreted as a volatile product (3%-15% of dosed radioactivity), and eliminated in urine (1% to 2% of dosed radioactivity). 52 In dogs and monkeys orally administered 200 mg/kg of Sucrose Octaisobutyrate ([ 14 C] label on sucrose), no dosed radioactivity was detected in whole blood or plasma and excretion in feces was 77% to 94% of dosed radioactivity and 62% to 85% of dosed radioactivity, respectively. 52 In dogs, Sucrose Octaisobutyrate was slowly absorbed, with less extensive hydrolysis in the gut, as compared to rats; in monkeys it was not absorbed or hydrolyzed in the gut.…”

“…52 In dogs and monkeys orally administered 200 mg/kg of Sucrose Octaisobutyrate ([ 14 C] label on sucrose), no dosed radioactivity was detected in whole blood or plasma and excretion in feces was 77% to 94% of dosed radioactivity and 62% to 85% of dosed radioactivity, respectively. 52 In dogs, Sucrose Octaisobutyrate was slowly absorbed, with less extensive hydrolysis in the gut, as compared to rats; in monkeys it was not absorbed or hydrolyzed in the gut. 52…”