Disrupted brain functional hub and causal connectivity in acute mild traumatic brain injury

Li, Fengfang; Lu, Liangliang; Chen, Huiyou; Wang, Peng; Chen, Yu‐Chen; Zhang, Hong; Yin, Xindao

doi:10.18632/aging.102484

Cited by 24 publications

(23 citation statements)

References 51 publications

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“…While several previous studies have successfully correlated their results with a decline in cognitive function (Li et al, 2019;Lu et al, 2019;Palacios et al, 2017), we did not find correlations between any other network and cognitive symptoms score. This may be in part attributed to the fact that the brain regions selected in these reports were not included in our study (e.g., frontal gyrus, substantia nigra, and temporal gyrus) as well as our smaller sample size.…”

Section: Correlation With Postconcussive Symptomscontrasting

confidence: 99%

Atypical resting state functional connectivity in mild traumatic brain injury

et al. 2021

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Objectives: This study aimed to investigate changes in three intrinsic functional connectivity networks (IFCNs; default mode network [DMN], salience network [SN], and task-positive network [TPN]) in individuals who had sustained a mild traumatic brain injury (mTBI).Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 27 mTBI patients with persistent postconcussive symptoms, along with 26 age-and sex-matched controls. These individuals were recruited from a Level-1 trauma center, at least 3 months after a traumatic episode. IFCNs were established based on seed-to-voxel, region-of-interest (ROI) to ROI, and independent component analyses (ICA). Subsequently, we analyzed the relationship between functional connectivity and postconcussive symptoms.Results: Seed-to-voxel analysis of rs-fMRI demonstrated decreased functional connectivity in the right lateral parietal lobe, part of the DMN, and increased functional connectivity in the supramarginal gyrus, part of the SN. Our TPN showed both hypoand hyperconnectivity dependent on seed location. Within network hypoconnectivity was observed in the visual network also using group comparison. Using an ICA, we identified altered network functional connectivity in regions within four IFCNs (sensorimotor, visual, DMN, and dorsal attentional). A significant negative correlation between dorsal attentional network connectivity and behavioral symptoms score was also found. Conclusions:Our findings indicate that rs-fMRI may be of use clinically in order to assess disrupted functional connectivity among IFCNs in mTBI patients. Improved mTBI diagnostic and prognostic information could be especially relevant for athletes looking to safely return to play, as well for individuals from the general population with persistent postconcussive symptoms months after injury, who hope to resume activity.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Correlation With Postconcussive Symptomscontrasting

confidence: 99%

Atypical resting state functional connectivity in mild traumatic brain injury

et al. 2021

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“…Some recent resting-state fMRI BOLD connectivity studies has identified disconnection functional coupling between the prefrontal cortex and these regions [40,41], which are consistent with our results. In addition, the CBF disconnection between the right CPL and bilateral ITG as well as the right FG was also been identified in mTBI patients, suggesting a disruption of the cerebellar-subcortical-cortical loop, which is partly consistent with the previous restingstate functional connectivity studies that indicate the CPL-FG disconnection and the abnormality of the cerebellum network in mTBI [42][43][44]. The disconnection of the cerebellum may be related to the functional deficits in cognitive integration in acute mTBI patients.…”

Section: Neural Plasticitysupporting

confidence: 84%

Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage

Shang

et al. 2020

Neural Plasticity

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Objective. The influence of cognitive impairment after mild traumatic brain injury (mTBI) on cerebral vascular perfusion has been widely concerned, yet the resting-state cerebral blood flow (CBF) connectivity alterations based on arterial spin labeling (ASL) in mild traumatic brain injury (mTBI) remain unclear. This study investigated region CBF and CBF connectivity features in acute mTBI patients, as well as the associations between CBF changes and cognitive impairment. Materials and Methods. Forty-five acute mTBI patients and 42 health controls underwent pseudocontinuous arterial spin labeling (pCASL) perfusion magnetic resonance imaging (MRI). The alterations in regional CBF and relationship between the CBF changes and cognitive impairment were detected. The ASL-CBF connectivity of the brain regions with regional CBF significant differences was also compared between two groups. Neuropsychological tests covered seven cognitive domains. Associations between the CBF changes and cognitive impairment were further investigated. Results. Compared with the healthy controls, the acute mTBI patients exhibited increased CBF in the bilateral inferior temporal gyrus (ITG) and decreased CBF in the right middle frontal gyrus (MFG), the bilateral superior frontal gyrus (SFG), and the right cerebellum posterior lobe (CPL). In the mTBI patients, significant correlations were identified between the CBF changes and cognitive impairment. Importantly, the acute mTBI patients exhibited CBF disconnections between the right CPL and right fusiform gyrus (FG) as well as bilateral ITG, between the left SFG and left middle occipital gyrus (MOG), and between the right SFG and right FG as well as right parahippocampal gyrus. Conclusion. Our results suggest that acute mTBI patients exhibit both regional CBF abnormalities and CBF connectivity deficits, which may underlie the cognitive impairment of the acute mTBI patients.

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“…In line with these reports, we found that the left MFG appeared hyperconnected within the DMN in the mTBI patients in the acute stage, and this result could be interpreted as a compensatory reallocation or recruitment of cognitive resources. Meanwhile, our previous study used GCA to analyze the causal connections in the acute mTBI patients and demonstrated significantly increased connectivity from the left ACC to the left MFG 34 . For mTBI patients, Benier et al and Sharp et al hypothesized that such hyperconnectivity patterns in the DMN could be related to dysfunction in working memory and attention switching during cognitive demand 35,36 .…”

Section: Discussionmentioning

confidence: 99%

Disrupted functional network connectivity predicts cognitive impairment after acute mild traumatic brain injury

Shang

et al. 2020

CNS Neurosci Ther

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Aims This study aimed to detect alterations of brain functional connectivity (FC) in acute mild traumatic brain injury (mTBI) and to estimate the extent to which these FC differences predicted the characteristics of posttraumatic cognitive impairment. Methods Resting‐state fMRI data were acquired from acute mTBI patients (n = 50) and healthy controls (HCs) (n = 43). Resting‐state networks (RSNs) were established based on independent component analysis (ICA), and functional network connectivity (FNC) analysis was performed. Subsequently, we analyzed the correlations between FNC abnormalities and cognitive impairment outcomes. Results Altered FC within the salience network (SN), sensorimotor network (SMN), default mode network (DMN), executive control network (ECN), visual network (VN), and cerebellum network (CN) was found in the mTBI group relative to the HC group. Moreover, different patterns of altered network interactions were found between the mTBI patients and HCs, including the SN‐CN, VN‐SMN, and ECN‐DMN connections. Correlations between functional disconnection and cognitive impairment measurements in acute mTBI patients were also found. Conclusion This study indicated that widespread FNC impairment and altered integration existed in mTBI patients at acute stage, suggesting that FNC disruption as a biomarker may be applied for the early diagnosis and prediction of cognitive impairment in mTBI.

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Disrupted brain functional hub and causal connectivity in acute mild traumatic brain injury

Cited by 24 publications

References 51 publications

Atypical resting state functional connectivity in mild traumatic brain injury

Atypical resting state functional connectivity in mild traumatic brain injury

Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage

Disrupted functional network connectivity predicts cognitive impairment after acute mild traumatic brain injury

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