Disrupted Frontoparietal Network Mediates White Matter Structure Dysfunction Associated with Cognitive Decline in Hypertension Patients

Li, Xin; Liang, Ying; Chen, Yaojing; Zhang, Junying; Wei, Dongfeng; Chen, Kewei; Shu, Ni; Reiman, Eric M.; Zhang, Zhanjun

doi:10.1523/jneurosci.5113-14.2015

Cited by 82 publications

(67 citation statements)

References 67 publications

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“…Although hypertension may eventually affect all of these domains, executive function is commonly affected earlier [26]. In a previous study, HPs showed declines in mainly executive function and attention compared with NPs, possibly due to the impact of white matter on executive function mediated by the frontoparietal network in the former [22]. In this study, HPs manifested mainly executive function impairment supporting this evidence indirectly, without orienting network decline.…”

Section: Discussionsupporting

confidence: 80%

“…Because HPs had reduced alerting network effect scores and greater difficulty resolving conflict than NPs did on POD 7 in this study, we suspect that they sustained more substantial damage to the frontal and parietal areas of the brain. Magnetic resonance imaging (MRI) studies have revealed altered patterns involving the parietal and frontal lobes in HPs relative to NPs [22]. The frontoparietal network is important for executive function, attention control, and working-memory processing [23].…”

Section: Discussionmentioning

confidence: 99%

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Effects of stage I hypertension on the recovery of early postoperative attention networks in elderly patients undergoing elective hip or knee arthroplasty surgery

Zhao

Yang

et al. 2019

Turk J Med Sci

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Background/aim: Hypertension is an important risk factor for cognitive impairment. This study explored whether elderly patients with stage I hypertension (HPs) and normotensive patients (NPs) showed differences in the recovery of postoperative attention network function according to the attentional network test (ANT) performance. Materials and methods: Of 110 patients screened, 25 HPs and 25 NPs completed this study. The Mini-Mental State Examination (MMSE) was applied to all participants before the operation and the ANT (on days 2 and 7) after the operation. All participants completed 1 day preoperatively and the ANT on postoperative days (PODs) 2 and 7. Results: Compared with NPs, HPs had significantly lower alerting network effect scores and more difficulty resolving conflict on POD 7. However, no significant difference was observed between the groups on POD 2. Orienting network performance was similar between the groups at all time points. Significant differences in alerting and executive control network performances were observed between PODs 2 and 7 in each group. Conclusion: HPs showed selective cognitive impairment at different time points following elective hip or knee arthroplasty. Compared with NPs, during the first postoperative week, HPs were more likely to experience delayed recovery of alerting and executive control network function, but not orienting network function.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Effects of stage I hypertension on the recovery of early postoperative attention networks in elderly patients undergoing elective hip or knee arthroplasty surgery

Zhao

Yang

et al. 2019

Turk J Med Sci

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“…The tractography differences noted between the MCI-highEF group and the MCI-lowEF group in the superior longitudinal fasciculus have been described not only in AD dementia [20], but also accompanying cognitive impairment in Parkinson’s disease and chronic hypertension. While the pathophysiology of these diseases may be different, it is important to note that differences in these regions accompany similar diminished executive changes [25, 26]. As such, it may be that a disruption in the efficiency of this tract in MCI is most indicative of whom will go on to develop dementia.…”

Section: Discussionmentioning

confidence: 99%

Retained executive abilities in mild cognitive impairment are associated with increased white matter network connectivity

et al. 2017

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Purpose To describe structural network differences in individuals with mild cognitive impairment (MCI) with high versus low executive abilities, as reflected by measures of white matter connectivity using diffusion tensor imaging (DTI). Materials and methods This was a retrospective, cross-sectional study. Of the 128 participants from the Alzheimer’s Disease Neuroimaging Initiative database who had both a DTI scan as well as a diagnosis of MCI, we used an executive function score to classify the top 15 scoring patients as high executive ability, and the bottom-scoring 16 patients as low executive ability. Using a regions-of-interest-based analysis, we constructed networks and calculated graph theory measures on the constructed networks. We used automated tractography in order to compare differences in major white matter tracts. Results The high executive ability group yielded greater network size, density and clustering coefficient. The high executive ability group reflected greater fractional anisotropy bilaterally in the inferior and superior longitudinal fasciculi. Conclusions The network measures of the high executive ability group demonstrated greater white matter integrity. This suggests that white matter reserve may confer greater protection of executive abilities. Loss of this reserve may lead to greater impairment in the progression to Alzheimer’s disease dementia.

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“…[24][25][26][27] Hypertension has been suggested to impair RSFC in older adults. 28 Higher total-cholesterol levels have been associated with both lower and higher RSFC within the DMN and lower RSFC within the SAL network, 29,30 but associations have not been found in all studies. 26 VRFs might therefore reduce brain functional health, which could increase vulnerability to AD pathology and/or cognitive impairments.…”

Section: Introductionmentioning

confidence: 81%

Vascular burden is associated with a decline in default-mode and global resting-state functional connectivity in individuals at risk for Alzheimer’s disease

Köbe

Binette

Vogel

et al. 2020

Preprint

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Introduction.Cross-sectional studies suggest that cardiovascular risk factors and Alzheimer's disease (AD) biomarkers are associated with abnormal brain resting-state functional connectivity in aging and AD; however, evidence is missing regarding longitudinal changes in functional connectivity. In this study, we investigate whether cholesterol levels and blood pressure are associated with changes in functional connectivity over time in asymptomatic individuals at risk for AD. The analyses were repeated with cerebral β-amyloid (Ab) and tau deposition in a subset of the participants. Methods. The study sample included 247 cognitively unimpaired individuals (185 women/ 62 men; mean [SD] age of 63 [5.3] years) of the PREVENT-AD cohort with a parental or multiplesibling history of sporadic AD. Plasma total-, HDL-, and LDL-cholesterol and systolic and diastolic blood pressure were measured at baseline. Global brain functional connectivity, and connectivity from canonical functional networks, were computed from resting-state functional MRI obtained at baseline and up to four years of annual follow-ups, using a predefined functional parcellation. A subset of participants underwent tau-PET ([ 18 F]Flortaucipir) and Aβ-PET ([ 18 F]NAV4694). Vascular and AD measures were examined as predictors of brain functional connectivity changes in linear mixed-effects models. Results. Higher total-cholesterol and LDL-cholesterol levels were associated with greater reduction of functional connectivity in the default-mode network over time. In addition, while overall whole-brain functional connectivity showed an increase over time across the entire sample higher diastolic blood pressure was associated with reduction in whole-brain functional connectivity. The associations were similar when the analyses were repeated using two other functional brain parcellations. The findings with total-cholesterol and diastolic blood pressure were also similar but attenuated when performed in a subsample of participants with PET (n=91), whereas AD biomarkers were not associated with changes in functional connectivity over time in this subsample. Conclusion. These findings provide evidence that vascular burden is associated with a decrease in brain functional connectivity over time in older adults with elevated risk for AD. The impact of vascular risk factors on functional brain changes might precede AD pathology-related changes.

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Disrupted Frontoparietal Network Mediates White Matter Structure Dysfunction Associated with Cognitive Decline in Hypertension Patients

Cited by 82 publications

References 67 publications

Effects of stage I hypertension on the recovery of early postoperative attention networks in elderly patients undergoing elective hip or knee arthroplasty surgery

Effects of stage I hypertension on the recovery of early postoperative attention networks in elderly patients undergoing elective hip or knee arthroplasty surgery

Retained executive abilities in mild cognitive impairment are associated with increased white matter network connectivity

Vascular burden is associated with a decline in default-mode and global resting-state functional connectivity in individuals at risk for Alzheimer’s disease

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