“…For example, there is a bi-directional relationship between fat and bone (Leiben et al, 2009), with bone marrow adipocytes and the bone-forming osteoblasts arising from the same mesenchymal stem cells (MSCs) (Beresford et al, 1992, Di Iorgi et al, 2008 and osteogenesis being influenced by leptin (Thomas et al, 1999, Hamrick et al, 2005, Evans et al, 2011. Although several studies have examined the effects of the loss of specific PWS interval regions/genes on bone (Khor et al, 2016, Kamaludin et al, 2016, Baraghithy et al, 2019, a study of the impact of losing all of the genes in the PWS locus is lacking. We have therefore conducted a study of the growth, morphology, microarchitecture and biomechanical properties of the appendicular bones of PWS-IC del mice and characterised the underlying endocrine phenotype.…”