Disrupted neural activity in unilateral vascular pulsatile tinnitus patients in the early stage of disease: Evidence from resting-state fMRI

Lv, Han; Liu, Zhaohui; Yan, Fuhua; Zhao, Peng; Li, Ting; Dong, Cheng; Wang, Zhenchang

doi:10.1016/j.pnpbp.2015.01.013

Cited by 28 publications

(25 citation statements)

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“…To discern whether brain regions not directly associated with auditory processing were activated during periods of auditory stimulation and silence, a nonregion of interest (non-ROI) was selected using published criteria [ 13 ]. The non-ROI covered the area immediately outside/adjacent to ROI minus an additional channel ( n − 1) over the occipital region, which has known functional relationships with the auditory sensory systems [ 24 – 27 ]. The channels corresponding to the non-ROI were 3 and 5 (right hemisphere) and 34 and 39 (left hemisphere; Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

Human Auditory and Adjacent Nonauditory Cerebral Cortices Are Hypermetabolic in Tinnitus as Measured by Functional Near-Infrared Spectroscopy (fNIRS)

et al. 2016

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Tinnitus is the phantom perception of sound in the absence of an acoustic stimulus. To date, the purported neural correlates of tinnitus from animal models have not been adequately characterized with translational technology in the human brain. The aim of the present study was to measure changes in oxy-hemoglobin concentration from regions of interest (ROI; auditory cortex) and non-ROI (adjacent nonauditory cortices) during auditory stimulation and silence in participants with subjective tinnitus appreciated equally in both ears and in nontinnitus controls using functional near-infrared spectroscopy (fNIRS). Control and tinnitus participants with normal/near-normal hearing were tested during a passive auditory task. Hemodynamic activity was monitored over ROI and non-ROI under episodic periods of auditory stimulation with 750 or 8000 Hz tones, broadband noise, and silence. During periods of silence, tinnitus participants maintained increased hemodynamic responses in ROI, while a significant deactivation was seen in controls. Interestingly, non-ROI activity was also increased in the tinnitus group as compared to controls during silence. The present results demonstrate that both auditory and select nonauditory cortices have elevated hemodynamic activity in participants with tinnitus in the absence of an external auditory stimulus, a finding that may reflect basic science neural correlates of tinnitus that ultimately contribute to phantom sound perception.

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Section: Methodsmentioning

confidence: 99%

Human Auditory and Adjacent Nonauditory Cerebral Cortices Are Hypermetabolic in Tinnitus as Measured by Functional Near-Infrared Spectroscopy (fNIRS)

et al. 2016

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“…For the precuneus, abnormal FC with the right MTG was significantly decreased in the LPTIN group compared with that in the RPTIN group according to our statistical analysis. The precuneus potentially serves as a core area for facilitating neuronal communication with rich behavioral correlates and plays a pivotal role in tinnitus, particularly in tinnitus‐related distress in PT patients . When comparing FC differences, idiopathic tinnitus patients with different disease duration, decreased FC between PCC and right precuneus/posterior cingulate regions was also reported to be significant in long‐term idiopathic tinnitus patients compared with recent‐onset tinnitus patients.…”

Section: Discussionmentioning

confidence: 52%

“…The precuneus potentially serves as a core area for facilitating neuronal communication with rich behavioral correlates 36 and plays a pivotal role in tinnitus, particularly in tinnitus-related distress in PT patients. 37 When comparing FC differences, idiopathic tinnitus patients with different disease duration, 32 decreased FC between PCC and right precuneus/posterior cingulate regions was also reported to be significant in longterm idiopathic tinnitus patients compared with recent-onset tinnitus patients. One recent study, which begins the work of identifying invariant neural correlates of tinnitus across different prolonged disease durations, proposed that DMNprecuneus decoupling is a potential marker of long-term tinnitus.…”

Section: Discussionmentioning

confidence: 96%

Long‐term reactions to pulsatile tinnitus are marked by weakened short‐range functional connectivity within a brain network in the right temporal lobe

Wang

Zhang

Zhao

et al. 2018

Magnetic Resonance Imaging

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Background There have been recent efforts to characterize brain functional activity features in patients with pulsatile tinnitus (PT). These efforts have revealed evidence of aberrant functional connectivity (FC) of the right middle temporal gyrus (MTG) in PT patients with prolonged disease duration. Purpose To assess the possible predictive effect of aberrant FC of MTG in PT patients with prolonged disease duration. Study Type Retrospective. Population Thirty‐four patients with recent‐onset PT (RPTIN), 24 patients with long‐term PT (LPTIN), and 35 age‐, gender‐, and education‐matched healthy controls were enrolled. Field Strength/Sequence 3.0T MRI system and echo‐planar imaging (EPI) sequence, 3D brain volume imaging (BRAVO) sequence. Assessment Functional MRI data preprocessing was performed in Data Processing & Analysis for Brain Imaging (DPABI) and Statistical Parametric Mapping (SPM) 8. The FC analyses were conducted using the software REST. Statistical Tests One‐way analysis of covariance was conducted between three groups with age and gender as covariates, and post‐hoc analysis was used to identify the sources of group effects. Pearson's correlation analysis was conducted for the z‐values of altered FC strength in the PT group and the clinical data. Results Among hubs belonging to the executive control network, the default mode network (DMN), and limbic network, the strength of FC was mainly decreased in the patient groups compared with normal controls (P < 0.05). Relative to RPTIN patients and normal controls, LPTIN patients were further characterized by significantly decreased FC between several short‐range brain regions adjacent to the seed (P < 0.05). Finally, disease duration was negatively correlated with decreased FC between the seed and right fusiform gyrus/parahippocampal gyrus, right inferior frontal gyrus, and right MTG (a brain area adjacent to the seed region). Data Conclusion Long‐term reactions to PT mainly involved weakened short‐range FC, especially within a functional network in the right temporal lobe. Level of Evidence: 4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.

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“…According to our previous research, tinnitus has been proven to be a symptom characterized by abnormal resting-state functional magnetic resonance imaging (rs-fMRI) (11)(12)(13)(14). The brain regions involved include sound detection regions, such as the insula and hippocampus (15,16), and auditory and nonauditory brain regions (17), such as the parahippocampal gyrus (18), posterior cingulate cortex (19), and anterior cingulate cortex (20).…”

Section: Introductionmentioning

confidence: 99%

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study

Qian

et al. 2020

Preprint

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Background: Many neuroanatomical alterations have been detected in patients with tinnitus in previous studies. However, little is known about morphological and structural covariance network (SCN) changes before and after long-term sound therapy. This study aimed to explore alterations in brain anatomical and SCN changes in patients with idiopathic tinnitus using voxel-based morphometry (VBM) analysis 24 weeks before and after sound therapy. Methods: Thirty-three tinnitus patients underwent magnetic resonance imaging scans at baseline and after 24 weeks of sound therapy. Twenty-six age- and sex-matched healthy control (HC) individuals also underwent two scans over a 24-week interval; 3.0T MRI and high-resolution 3D structural images were acquired with a 3D-BRAVO pulse sequence. Structural image data preprocessing was performed using the VBM8 toolbox. The Tinnitus Handicap Inventory (THI) score was acquired in the tinnitus group to assess the severity of tinnitus and tinnitus-related distress. Two-way mixed model analysis of variance (ANOVA) and post hoc analyses were performed to determine differences between the two groups (patients and HCs) and between the two scans (at baseline and at the 24th week). Two-sample t tests, paired-samples t tests, and Pearson’s correlation analysis were used in the post hoc analysis.Results: Interaction effects between the two groups and the two scans demonstrated significantly different gray matter (GM) volume in the right parahippocampus gyrus, right caudate, left superior temporal gyrus, left cuneus gyrus and right calcarine gyrus; we found significantly decreased GM volume in the above five brain regions among the tinnitus patients before sound therapy (baseline) compared to that in the HC group. The 24-week sound therapy group demonstrated significantly greater brain volume compared with the baseline group among these brain regions. We did not find significant differences in brain regions between the 24-week sound therapy and HC groups. The SCN results showed that the left superior temporal gyrus and left rolandic operculum were significantly different in nodal efficiency, nodal degree centrality and nodal betweenness centrality after FDR correction. Decreased THI scores and GM volume changes between the left thalamus and right thalamus were not correlated. Conclusions: This study characterized the effect of sound therapy on brain GM volume, especially in the left superior temporal lobe. Notably, sound therapy had a normalizing effect on tinnitus patients.

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Disrupted neural activity in unilateral vascular pulsatile tinnitus patients in the early stage of disease: Evidence from resting-state fMRI

Cited by 28 publications

References 100 publications

Human Auditory and Adjacent Nonauditory Cerebral Cortices Are Hypermetabolic in Tinnitus as Measured by Functional Near-Infrared Spectroscopy (fNIRS)

Human Auditory and Adjacent Nonauditory Cerebral Cortices Are Hypermetabolic in Tinnitus as Measured by Functional Near-Infrared Spectroscopy (fNIRS)

Long‐term reactions to pulsatile tinnitus are marked by weakened short‐range functional connectivity within a brain network in the right temporal lobe

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study

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