Disrupted Resting-state Functional Connectivity of the Nucleus Basalis of Meynert in Parkinson’s Disease with Mild Cognitive Impairment

Zhang, Chao; Wu, Chen; Zhang, Haiyan; Dou, Weiqiang; Li, Weidong; Sami, Muhammad Umair; Xu, Kai

doi:10.1016/j.neuroscience.2020.07.008

Cited by 16 publications

(11 citation statements)

References 63 publications

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“…Cholinergic pedunculopontine nucleus neuronal loss in PD is believed to be attributable to cognitive damage ( 128 – 130 ). The decreased volume and the disrupted resting-state functional connectivity of the basal nucleus of Meynert (BNM), the main source of cholinergic innervation ( 131 , 132 ), were found to be correlated with cognitive decline in PD ( 133 – 135 ). Rivastigmine, an inhibitor of acetylcholinesterase and butyrylcholinesterase, is effective in treating RBD and dementia associated with PD separately ( 136 , 137 ).…”

Section: Discussionmentioning

confidence: 99%

Association Between REM Sleep Behavior Disorder and Cognitive Dysfunctions in Parkinson's Disease: A Systematic Review and Meta-Analysis of Observational Studies

Mao

Huang

et al. 2020

Front. Neurol.

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Background: Rapid eye movement sleep behavior disorder (RBD) is thought to be a prodromal symptom of Parkinson's disease (PD). RBD is also thought to be involved in cognitive decline and dementia in PD. In PD, although the relationship between RBD and cognitive dysfunctions was confirmed by considerable studies, whether RBD was associated with distinct types of cognitive defects is worth of study. Objectives: This systematic review summarizes the evidence relating to cognitive dysfunction in PD patients with RBD (PD-RBD) and those without and explores their specificity to cognitive domains. Methods: A meta-analysis using a random-effects model was performed for 16 different cognitive domains, including global cognitive function, memory (long-term verbal recall, long-term verbal recognition, long-term visual recall, short-term spatial recall, and short-term verbal recall), executive function (general, fluid reasoning, generativity, shifting, inhibition, and updating), language, processing speed/complex attention/working memory, visuospatial/constructional ability, and psychomotor ability. The cognitive difference between the groups of patients was measured as a standardized mean difference (SMD, Cohen's d). PD-RBD patients were classified into Confirmed-RBD (definite diagnosis with polysomnography, PSG) and Probable-RBD (without PSG re-confirmation). In some domains, RBD patients could not be analyzed separately due to the exiguity of primary studies; this analysis refers to such RBD patients as "Mixed-RBD." Results: Thirty-nine studies with 6,695 PD subjects were finally included. Confirmed-RBD patients showed worse performance than those without in global cognitive function, long-term verbal recall, long-term verbal recognition, generativity, inhibition, shifting, language, and visuospatial/constructional ability; Probable-RBD, in global cognitive function and shifting; and Mixed-RBD, in long-term visual recall, Mao et al. RBD and Cognition in PD? short-term spatial recall, general executive function, and processing speed/complex attention/working memory. Conclusion: This meta-analysis strongly suggests a relationship between RBD, Confirmed-RBD in particular, and cognitive dysfunctions in PD patients. Early and routine screening by sensitive and targeted cognitive tasks is necessary for all PD-RBD patients because it may offer the therapeutic time window before they evolve to irreversible dementia.

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Section: Discussionmentioning

confidence: 99%

Association Between REM Sleep Behavior Disorder and Cognitive Dysfunctions in Parkinson's Disease: A Systematic Review and Meta-Analysis of Observational Studies

Mao

Huang

et al. 2020

Front. Neurol.

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“…The brain is a complex network composed of multiple subnetworks supporting different functional properties ( Shirer et al, 2012 ). Resting-state functional MRI (rs-fMRI) is an established tool to explore intrinsic brain activity non-invasively and effectively, and it has been widely used in neuropsychiatric diseases ( Liu et al, 2015 , 2017 ; Zhang et al, 2020 ). Regional brain activity-based rs-fMRI analysis of patients with PSA (i.e., stroke occurred in the left hemisphere) showed decreased local synchronization in multiple brain areas of the left hemisphere ( Yang et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Disrupted Functional Connectivity Within and Between Resting-State Networks in the Subacute Stage of Post-stroke Aphasia

et al. 2021

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Background: Post-stroke aphasia (PSA) results from brain network disorders caused by focal stroke lesions. However, it still remains largely unclear whether the impairment is present in intra- and internetwork functional connectivity (FC) within each resting-state network (RSN) and between RSNs in the subacute stage of PSA.Objectives: This study aimed to investigate the resting-state FC within and between RSNs in patients with PSA and observe the relationships between FC alterations and Western Aphasia Battery (WAB) measures.Methods: A total of 20 individuals with subacute PSA and 20 healthy controls (HCs) were recruited for functional MRI (fMRI) scanning, and only patients with PSA underwent WAB assessment. Independent component analysis was carried out to identify RSNs. Two-sample t-tests were used to calculate intra- and internetwork FC differences between patients with PSA and HCs. The results were corrected for multiple comparisons using the false discovery rate (FDR correction, p < 0.05). Partial correlation analysis was performed to observe the relationship between FC and WAB scores with age, gender, mean framewise displacement, and lesion volume as covariates (p < 0.05).Results: Compared to HCs, patients with PSA showed a significant increase in intranetwork FC in the salience network (SN). For internetwork FC analysis, patients showed a significantly increased coupling between left frontoparietal network (lFPN) and SN and decreased coupling between lFPN and right frontoparietal network (rFPN) as well as between lFPN and posterior default mode network (pDMN) (FDR correction, p < 0.05). Finally, a significant positive correlation was found between the intergroup difference of FC (lFPN-rFPN) and auditory-verbal comprehension (p < 0.05).Conclusion: Altered FC was revealed within and between multiple RSNs in patients with PSA at the subacute stage. Reduced FC between lFPN and rFPN was the key element participating in language destruction. These findings proved that PSA is a brain network disorder caused by focal lesions; besides, it may improve our understanding of the pathophysiological mechanisms of patients with PSA at the subacute stage.

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“…However, lower volume is found in more advanced PD [ 187 , 188 ], correlating with cortical thinning in the bilateral posterior cingulate, parietal, and frontal and left insular regions in patients with PD-MCI [ 189 ]. This is in line with decreased metabolism in the parietal and occipital cortices [ 190 ] and decreased functional connectivity between the nbM and the right superior parietal lobe and postcentral gyrus [ 191 ]. In addition, patients with lower substantia innominata volume had decreased connectivity between the caudate and frontal, parietal, temporal, precentral and PCC [ 192 ].…”

Section: Regions Of the Limbic Systemmentioning

confidence: 58%

Imaging the Limbic System in Parkinson’s Disease—A Review of Limbic Pathology and Clinical Symptoms

et al. 2022

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The limbic system describes a complex of brain structures central for memory, learning, as well as goal directed and emotional behavior. In addition to pathological studies, recent findings using in vivo structural and functional imaging of the brain pinpoint the vulnerability of limbic structures to neurodegeneration in Parkinson’s disease (PD) throughout the disease course. Accordingly, dysfunction of the limbic system is critically related to the symptom complex which characterizes PD, including neuropsychiatric, vegetative, and motor symptoms, and their heterogeneity in patients with PD. The aim of this systematic review was to put the spotlight on neuroimaging of the limbic system in PD and to give an overview of the most important structures affected by the disease, their function, disease related alterations, and corresponding clinical manifestations. PubMed was searched in order to identify the most recent studies that investigate the limbic system in PD with the help of neuroimaging methods. First, PD related neuropathological changes and corresponding clinical symptoms of each limbic system region are reviewed, and, finally, a network integration of the limbic system within the complex of PD pathology is discussed.

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Disrupted Resting-state Functional Connectivity of the Nucleus Basalis of Meynert in Parkinson’s Disease with Mild Cognitive Impairment

Cited by 16 publications

References 63 publications

Association Between REM Sleep Behavior Disorder and Cognitive Dysfunctions in Parkinson's Disease: A Systematic Review and Meta-Analysis of Observational Studies

Association Between REM Sleep Behavior Disorder and Cognitive Dysfunctions in Parkinson's Disease: A Systematic Review and Meta-Analysis of Observational Studies

Disrupted Functional Connectivity Within and Between Resting-State Networks in the Subacute Stage of Post-stroke Aphasia

Imaging the Limbic System in Parkinson’s Disease—A Review of Limbic Pathology and Clinical Symptoms

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