Disrupting the Circadian Clock Mechanism in Cardiomyocytes Exacerbates the LQT3-related Phenotype in Scn5aΔKPQ/+Mice

Wayland, Jennifer L; Shah, Fiaz Hussain; Samuels, Kaitlyn; Seward, Tanya; Schroder, Elizabeth A.; Delisle, Brian P.

doi:10.1016/j.bpj.2019.11.718

Cited by 2 publications

(1 citation statement)

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“…[7][8][9] Predictably, the genetic or environmental disruption of the circadian clock is characterized by high prevalence of diseases or exacerbated pathological status. [10][11][12] In the past few years, increasing experimental evidence has shown a strong interaction between the circadian clock and lipid dysmetabolism or obesity, but the mechanisms by which the circadian clock regulates of lipid metabolism have not been fully elucidated. In this review, we will initially describe the relationship between obesity and the circadian clock; then, we will focus on the potential mechanisms by which the circadian clock regulates lipid metabolism.…”

Section: Introductionmentioning

confidence: 99%

Circadian rhythms and obesity: Timekeeping governs lipid metabolism

Yao

et al. 2020

Journal of Pineal Research

115

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Almost all living organisms have evolved autoregulatory transcriptional‐translational feedback loops that produce oscillations with a period of approximately 24‐h. These endogenous time keeping mechanisms are called circadian clocks. The main function of these circadian clocks is to drive overt circadian rhythms in the physiology of the organisms to ensure that main physiological functions are in synchrony with the external environment. Disruption of circadian rhythms caused by genetic or environmental factors has long‐term consequences for metabolic health. Of relevance, host circadian rhythmicity and lipid metabolism are increasingly recognized to cross‐regulate and the circadian clock‐lipid metabolism interplay may involve in the development of obesity. Multiple systemic and molecular mechanisms, such as hormones (ie, melatonin, leptin, and glucocorticoid), the gut microbiome, and energy metabolism, link the circadian clock and lipid metabolism, and predictably, the deregulation of circadian clock‐lipid metabolism interplay can increase the risk of obesity, which in turn may exacerbate circadian disorganization. Feeding time and dietary nutrients are two of key environmental Zeitgebers affecting the circadian rhythm‐lipid metabolism interplay, and the influencing mechanisms in obesity development are highlighted in this review. Together, the characterization of the clock machinery in lipid metabolism aimed at producing a healthy circadian lifestyle may improve obesity care.

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