Disruption of brain white matter microstructure in women with anorexia nervosa

Via, Esther; Zalesky, Andrew; Sánchez, Isabel; Forcano, Laura; Harrison, Ben J; Pujol, Jesús; Fernández‐Aranda, Fernando; Menchón, José M.; Soriano‐Mas, Carles; Cardoner, Narcı́s; Fornito, Alex

doi:10.1503/jpn.130135

Cited by 66 publications

(83 citation statements)

References 61 publications

(91 reference statements)

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“…These patterns of connectivity would suggest that the SLF has a role in the executive functions of motor planning, visuospatial working memory, and language; this is confirmed by reports of association of SLF white matter integrity with measures of executive function (Sasson et al, 2013). Other psychiatric disorders that have been associated with abnormal indices of SLF white matter integrity include anorexia nervosa (Via et al, 2014;Frieling et al, 2012) and borderline personality disorder (Maier-Hein et al, 2014). Our finding of decreased FA in SLF I and II indicates impaired connectivity between the frontal lobes and medial, superior, and caudal inferior parietal lobes.…”

Section: Discussionmentioning

confidence: 68%

White Matter Integrity Reductions in Intermittent Explosive Disorder

Lee

Arfanakis

Evia

et al. 2016

Neuropsychopharmacol

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Intermittent explosive disorder (IED), as described in DSM-5, is the categorical expression of pathological impulsive aggression. Previous work has identified neurobiological correlates of the disorder in patterns of frontal-limbic brain activity and dysregulation of serotonergic neurotransmission. Given the importance of short-and-long range white matter connections of the brain in social and emotional behavior, studies of white matter connectivity in impulsive aggression are warranted. Diffusion tensor imaging (DTI) studies in the related conditions of antisocial and borderline personality disorder have produced preliminary evidence of disturbed white matter connectivity in these disorders, but to date there have been no DTI studies in IED. A total of 132 male and female adults between the ages of 18 and 55 years underwent Turboprop-DTI on a 3-Tesla MRI scanner. Of these, 42 subjects had IED, 40 were normal controls, and 50 were clinical psychiatric controls with psychiatric disorders without IED. All subjects were free of alcohol, psychotropic medications, or drugs of abuse. The diffusion tensor was calculated in each voxel and maps of fractional anisotropy (FA) were generated. Tract-based spatial statistics (TBSS) were used to compare FA along the white matter skeleton among the three subject groups. IED was associated with lower FA in two clusters located in the superior longitudinal fasciculus (SLF) when compared with the psychiatric and healthy controls. Impulsive aggression and borderline personality disorder, but not psychopathy or antisocial personality disorder, was associated with lower FA in the two clusters within the SLF. In conclusion, IED was associated with lower white matter integrity in long-range connections between the frontal and temporoparietal regions.

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Section: Discussionmentioning

confidence: 68%

White Matter Integrity Reductions in Intermittent Explosive Disorder

Lee

Arfanakis

Evia

et al. 2016

Neuropsychopharmacol

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“…FA is related to axon diameter, packing density of fibers, membrane permeability and myelination and is thought to reflect axon integrity (Jones et al, 2013). Four studies have suggested reduced FA in ill anorexia nervosa in the fornix, with evidence of lower FA in fronto-occipital tracts and cerebellum compared with controls (Frank et al, 2013b;Kazlouski et al, 2011;Nagahara et al, 2014;Via et al, 2014). After recovery from anorexia nervosa, small studies (n between 9 and 12 subjects) found differing results with reduced FA in the posterior thalamic radiation (Frieling et al, 2012) or no differences compared with controls (Yau et al, 2013), and clarification is needed.…”

Section: Introductionmentioning

confidence: 99%

Greater Insula White Matter Fiber Connectivity in Women Recovered from Anorexia Nervosa

Shott

Pryor

Yang

et al. 2015

Neuropsychopharmacol

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Anorexia nervosa is a severe psychiatric disorder associated with reduced drive to eat. Altered taste-reward circuit white matter fiber organization in anorexia nervosa after recovery could indicate a biological marker that alters the normal motivation to eat. Women recovered from restricting-type anorexia (Recovered AN, n = 24, age = 30.3 ± 8.1 years) and healthy controls (n = 24, age = 27.4 ± 6.3 years) underwent diffusion weighted imaging of the brain. Probabilistic tractography analyses calculated brain white matter connectivity (streamlines) as an estimate of fiber connections in taste-reward-related white matter tracts, and microstructural integrity (fractional anisotropy, FA) was assessed using tract-based spatial statistics. Recovered AN showed significantly (range Po0.05-0.001, Bonferroni corrected) greater white matter connectivity between bilateral insula regions and ventral striatum, left insula and middle orbitofrontal cortex (OFC), and right insula projecting to gyrus rectus and medial OFC. Duration of illness predicted connectivity of tracts projecting from the insula to ventral striatum and OFC. Microstructural integrity was lower in Recovered AN in most insula white matter tracts, as was whole-brain FA in parts of the anterior corona radiata, external capsule, and cerebellum (Po0.05, family-wise errorcorrected). This study indicates higher structural white matter connectivity, an estimate of fibers connections, in anorexia after recovery in tracts that connect taste-reward processing regions. Greater connectivity together with less-fiber integrity could indicate altered neural activity between those regions, which could interfere with normal food-reward circuit function. Correlations between connectivity and illness duration suggest that connectivity could be a marker for illness severity. Whether greater connectivity can predict prognosis of the disorder requires further study.

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“…Via et al [53] Current AN restricting subtype FA: Lower in the parietal part of the left SLF and the fornix.…”

Section: Md: Higher Value In the Fornixmentioning

confidence: 99%

“…Localization of disturbances in frontal-parietal and cingulum WM suggests that these pathways, which are important for cognitive control, may be susceptible to core AN pathology. Malnutrition seems to have potentially lasting effects on WM integrity and degree of recovery MD: Lower in frontal, parietal and cingulum [49] Yes Yes Yes Partially Yes U Yes Yes Nagahara et al [7] Yes Yes Yes No Yes U Yes No Via et al [53] Yes Yes Yes Yes Yes U Yes Yes Frieling et al [5] Yes Yes Yes Yes Yes U Yes Yes Yau et al [39] Yes punishment questionnaire [37] and the multidimensional perfectionism scale [38] . In addition, in one study a molar sucrose and a control solution for sweetness and pleasantness were rated on a 9-point Likert scale.…”

Section: Fa (Recan): Insignificant Alterationmentioning

confidence: 99%

White matter alterations in anorexia nervosa: A systematic review of diffusion tensor imaging studies

Monzón¹,

Hay²,

Foroughi³

et al. 2016

WJP

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AIM:To identify findings concerning white matter (WM) fibre microstructural alterations in anorexia nervosa (AN). METHODS:A systematic electronic search was undertaken in several databases up to April 2015. The search strategy aimed to locate all studies published in English or Spanish that included participants with AN and which investigated WM using diffusion tensor imaging (DTI). Trials were assessed for quality assessment according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses checklist and a published quality index guideline. RESULTS:A total of 6 studies met the inclusion criteria, four of people in the acute state of the illness, one included both recovered and unwell participants, and one included people who had recovered. Participants were female with ages ranging from 14 to 29 years. All studies but one measured a range of psychopathological features. Fractional anisotropy and mean diffusivity were the main DTI correlates reported. Alterations were reported in a range of WM structures of the limbic SYSTEMATIC REVIEWS Core tip: The present systematic review identifies the latest research on white matter (WM) brain alterations in anorexia nervosa (AN). The WM architecture has been poorly understood due to its structure forming deep parts of the brain. It transmits information between cortical and subcortical structures. New advances in imaging methods with diffusion tensor imaging, allow its characterization and integrity analysis. Alterations in areas of fornix, cingulum, corpus callosum, cerebellum, superior longitudinal fasciculus and thalamus have been found in AN. They could be related to symptoms like anxiety, body image perception, reward processing and cognitive abilities.Martin Monzon B, Hay P, Foroughi N, Touyz S. White matter alterations in anorexia nervosa: A systematic review of diffusion tensor imaging studies.

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Disruption of brain white matter microstructure in women with anorexia nervosa

Cited by 66 publications

References 61 publications

White Matter Integrity Reductions in Intermittent Explosive Disorder

White Matter Integrity Reductions in Intermittent Explosive Disorder

Greater Insula White Matter Fiber Connectivity in Women Recovered from Anorexia Nervosa

White matter alterations in anorexia nervosa: A systematic review of diffusion tensor imaging studies

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