2020
DOI: 10.1242/dev.182758
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Disruption of dmrt1 rescues the all-male phenotype of cyp19a1a mutant in zebrafish A Novel insight into the roles of aromatase/estrogens in gonadal differentiation and early folliculogenesis

Abstract: Sex determination and differentiation are complex processes controlled by many different factors; however, the relationships among these factors are poorly understood. Zebrafish gonadal differentiation exhibits high plasticity involving multiple factors and pathways, which provides an excellent model for investigating the interactions between them. Ovarian aromatase (cyp19a1a) and dmrt1 are key factors in directing vertebrate ovary and testis differentiation, respectively. Knockout of zebrafish cyp19a1a leads … Show more

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Cited by 49 publications
(64 citation statements)
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“…In cyp19a1a -/+ ;dmrt1 -/- (HM) siblings, all gonads examined had numerous early-stage oocytes (Fig. 4A), consistent with the previously reported dmrt1 mutant female-bias phenotype [11,53]. As expected, all cyp19a1a -/-;dmrt1 -/+ (MH) sibling gonads examined were testis-like and lacked the oocyte marker, Buc (Fig.…”
Section: Loss Of Dmrt1 Restores Bipotential and Female Development Insupporting
confidence: 90%
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“…In cyp19a1a -/+ ;dmrt1 -/- (HM) siblings, all gonads examined had numerous early-stage oocytes (Fig. 4A), consistent with the previously reported dmrt1 mutant female-bias phenotype [11,53]. As expected, all cyp19a1a -/-;dmrt1 -/+ (MH) sibling gonads examined were testis-like and lacked the oocyte marker, Buc (Fig.…”
Section: Loss Of Dmrt1 Restores Bipotential and Female Development Insupporting
confidence: 90%
“…In contrast to loss of rbpms2 function, female fates can be restored or prolonged in mutants lacking cyp19a1a and dmrt1. Taken together this work and the work of Wu and colleagues [53] indicates that cyp19a1a acts during at least two steps of female specific differentiation. Early cyp19a1a-mediated suppression of dmrt1 is required to establish a bipotential gonad and initiate female fate acquisition in zebrafish, possibly by promoting expression of rbpms2 which is required for female specific differentiation, even in the absence of Dmrt1.…”
Section: Loss Of Dmrt1 Restores Bipotential and Female Development Insupporting
confidence: 75%
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