Disruption of Pdia3 gene results in bone abnormality and affects 1α,25-dihydroxy-vitamin D3-induced rapid activation of PKC

Wang, Yun; Chen, Jiaxuan; Lee, Christophe S.D.; Nizkorodov, Alexandr; Riemenschneider, Kelsie; Martín, David; Hyzy, Sharon L.; Schwartz, Zvi; Boyan, Barbara D.

doi:10.1016/j.jsbmb.2010.05.004

Cited by 42 publications

(40 citation statements)

References 13 publications

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“…By establishing the role of Pdia3 in 1␣,25(OH) 2 D 3 -dependent gene transcription, protein secretion and mineralization, we showed that the proposed Pdia3 signaling pathway has significant physiological relevance. This conclusion is supported by studies showing that mice with reduced levels of Pdia3 (Pdia3 ϩ/Ϫ ) have a defective bone phenotype (50).…”

Section: Discussionmentioning

confidence: 77%

Protein-disulfide Isomerase-associated 3 (Pdia3) Mediates the Membrane Response to 1,25-Dihydroxyvitamin D3 in Osteoblasts

Chen

Olivares-Navarrete

Wang

et al. 2010

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 77%

Protein-disulfide Isomerase-associated 3 (Pdia3) Mediates the Membrane Response to 1,25-Dihydroxyvitamin D3 in Osteoblasts

Chen

Olivares-Navarrete

Wang

et al. 2010

Journal of Biological Chemistry

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“…This effect is abolished in PDIA3-knockdown cells, indicating that PDIA3 mediates the 1a,25(OH) 2 D 3 membrane response [39]. The PDIA3 knockout mouse is embryonically lethal by day E10.5 [51], confirming the importance of this protein in stem cell differentiation and …”

Section: Vitamin D Receptor Expressionmentioning

confidence: 88%

“…In addition, PDIA3 deficiency in PDIA3 + / -mice results in skeletal anomalies that affect trabecular and cortical bone [51]. Interestingly, the stimulatory effect of the 1a,25(OH) 2 EBs also exhibited increased expression of mRNAs for a2 and b1 integrin subunits in cultures grown in osteogenic medium.…”

mentioning

confidence: 99%

Osteogenic Differentiation of Stem Cells Alters Vitamin D Receptor Expression

Olivares-Navarrete

Sutha

Hyzy

et al. 2012

Stem Cells and Development

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“…However, chondrocytes isolated from costochondral cartilage of VDR knockout mice and Ca 2+ influx studies in the guts of these mice demonstrate that 1α,25(OH) 2 D 3 still elicits rapid activation of PKC and a biological response [38,39]. Studies using Pdia3 conditional knockout mice [40], Pdia3-silenced osteoblasts [41], and Pdia3 ± heterozygote mice [42] have demonstrated a loss of rapid activation of PKC and release of PGE 2 , decreased osteopontin production and alkaline phosphatase activity, and bone and cartilage abnormalities.…”

Section: Alternative Membrane Receptorsmentioning

confidence: 99%

Rapid steroid hormone actions via membrane receptors

Schwartz

Verma

Bivens

et al. 2016

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Steroid hormones regulate a wide variety of physiological and developmental functions. Traditional steroid hormone signaling acts through nuclear and cytosolic receptors, altering gene transcription and subsequently regulating cellular activity. This is particularly important in hormonally-responsive cancers, where therapies that target classical steroid hormone receptors have become clinical staples in the treatment and management of disease. Much progress has been made in the last decade in detecting novel receptors and elucidating their mechanisms, particularly their rapid signaling effects and subsequent impact on tumorigenesis. Many of these receptors are membrane-bound and lack DNA-binding sites, functionally separating them from their classical cytosolic receptor counterparts. Membrane-bound receptors have been implicated in a number of pathways that disrupt the cell cycle and impact tumorigenesis. Among these are pathways that involve phospholipase D, phospholipase C, and phosphoinositide-3 kinase. The crosstalk between these pathways has been shown to affect apoptosis and proliferation in cardiac cells, osteoblasts, and chondrocytes as well as cancer cells. This review focuses on rapid signaling by 17β-estradiol and 1α,25-dihydroxy vitamin D3 to examine the integrated actions of classical and rapid steroid signaling pathways both in contrast to each other and in concert with other rapid signaling pathways. This new approach lends insight into rapid signaling by steroid hormones and its potential for use in targeted drug therapies that maximize the benefits of traditional steroid hormone-directed therapies while mitigating their less desirable effects.

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Disruption of Pdia3 gene results in bone abnormality and affects 1α,25-dihydroxy-vitamin D3-induced rapid activation of PKC

Cited by 42 publications

References 13 publications

Protein-disulfide Isomerase-associated 3 (Pdia3) Mediates the Membrane Response to 1,25-Dihydroxyvitamin D3 in Osteoblasts

Protein-disulfide Isomerase-associated 3 (Pdia3) Mediates the Membrane Response to 1,25-Dihydroxyvitamin D3 in Osteoblasts

Osteogenic Differentiation of Stem Cells Alters Vitamin D Receptor Expression

Rapid steroid hormone actions via membrane receptors

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