Protein-disulfide Isomerase-associated 3 (Pdia3) Mediates the Membrane Response to 1,25-Dihydroxyvitamin D3 in Osteoblasts

Chen, Jiaxuan; Olivares-Navarrete, René; Wang, Yun; Herman, Tyler R.; Boyan, Barbara D.; Schwartz, Zvi

doi:10.1074/jbc.m110.157115

Cited by 90 publications

(90 citation statements)

References 49 publications

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“…ERp57 modulates the vitamin D-mediated anti-cancer activity, specifically in breast cancer; ERp57 knockdown selectively increases the sensitivity of MCF-7 cells to agents related to vitamin D [48]. 1,25(OH) 2 D 3 stimulates PLA 2 -dependent rapid release of prostaglandin E 2 (PGE 2 ), activation of protein kinase C (PKC), and regulation of bone-related gene transcription and mineralization in osteoblast-like MC3T3-E1 cells via a mechanism involving ERp57 [45]. These data suggest that ERp57 is an important initiator of 1,25(OH) 2 D 3 -stimulated membrane signaling pathways, which have both genomic and non-genomic effects during osteoblast maturation [45].…”

Section: Erp57 On the Cell Surfacementioning

confidence: 99%

“…1,25(OH) 2 D 3 stimulates PLA 2 -dependent rapid release of prostaglandin E 2 (PGE 2 ), activation of protein kinase C (PKC), and regulation of bone-related gene transcription and mineralization in osteoblast-like MC3T3-E1 cells via a mechanism involving ERp57 [45]. These data suggest that ERp57 is an important initiator of 1,25(OH) 2 D 3 -stimulated membrane signaling pathways, which have both genomic and non-genomic effects during osteoblast maturation [45]. Boyan et al have also shown that the process of extracellular matrix reorganization brought up by chondrocytes is regulated by 1,25(OH) 2 D 3 interacting with ERp57, contained in the matrix vesicles [44].…”

Section: Erp57 On the Cell Surfacementioning

confidence: 99%

“…Rapid responses are not expected to be the result of the involvement of the classical vitamin D receptor (VDR), which operates through binding to DNA and the activation of gene expression, and therefore requires longer times to produce detectable events. The rapid cell response (seconds or minutes) after stimulation with 1α,25-(OH) 2 D 3 activates numerous cascades of signal transduction, involving signaling proteins such as phospholipases C (PLC) and A 2 (PLA 2 ), protein kinases C (PKC) and ERK (extracellular response activated kinase), all of which have been shown to respond to the formation of the ERp57-1α,25-(OH) 2 D 3 complex [44,45]. PKCα and PKCβ are both activated by 1α,25-(OH) 2 D 3 binding to ERp57 in isolated intestinal epithelial cells from chicks, with subsequent stimulation of phosphate uptake [43,46].…”

Section: Erp57 On the Cell Surfacementioning

confidence: 99%

“…Internalization and nuclear import [43-44, 46, 49] Regulation of bone-related gene transcription and mineralization in osteoblast-like MC3T3-E1 cells [45] Interaction with the angiotensin II receptor [50] Interaction with vasopressin receptor [51] Interaction with the all-trans retinoic acid receptor α [55] Interaction with STAT3 in the lipid raft fraction of cell membrane Participation of a signal transduction pathway initiating at the cell surface [57,58] Cytosol Interaction with STAT3 in the cytosol Present in a multiprotein complex [56][57][58]78] Interaction with the all-trans retinoic acid receptor α Transport of the ligand-receptor complex into the nucleus (in the Sertoli cells) [55] Interaction with NFκB in the cytosol of leukemic cells [49] Redox activity; interaction with Maintenance of the reduced state of Ref-1 (complex, shuttles between the cytosol and the nucleus) [13] Interaction with mTOR Assembly and functioning of the multiprotein complex mTORC1; Appears to be at least in part responsible for the redox dependence of mTORC1 activity [64] Nucleus Redox activity; interaction with Ref-…”

Section: Endoplasmic Reticulummentioning

confidence: 99%

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ERp57/GRP58: A protein with multiple functions

Turano

Gaucci

Grillo

et al. 2011

Cellular and Molecular Biology Letters

114

108

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Abbreviations used: 1α,25-(OH) 2 D 3 -1α,25-dihydroxycholecalciferol and calcitriol; APE/Ref-1 -apurinic (apyrimidinic) endonuclease/redox-factor 1; CRP -C-reactive protein; ER -endoplasmic reticulum; ERAD endoplasmic reticulum associated protein degradation; mTORC -mammalian target of rapamycin complex; PDI -protein disulfide isomerase; PKC -protein kinases C; PLA 2 -phospholipases A 2 ; Plc -peptide loading complex; PLC -phospholipase C; PrP SC -scrapie prion protein (misfolded prions); STAT -signal transducer and activator of transcription; STAT3 -signal transducer and activator of transcription 3; SV40 virus -simian virus 40; VDR -vitamin D receptor Review ERp57/GRP58: A PROTEIN WITH MULTIPLE FUNCTIONSCARLO TURANO*, ELISA GAUCCI, CATERINA GRILLO and SILVIA CHICHIARELLI Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza -Università di Roma, Italy Abstract: The protein ERp57/GRP58 is a stress-responsive protein and a component of the protein disulfide isomerase family. Its functions in the endoplasmic reticulum are well known, concerning mainly the proper folding and quality control of glycoproteins, and participation in the assembly of the major histocompatibility complex class 1. However, ERp57 is present in many other subcellular locations, where it is involved in a variety of functions, primarily suggested by its participation in complexes with other proteins and even with DNA. While in some instances these roles need to be confirmed by further studies, a great number of observations support the participation of ERp57 in signal transduction from the cell surface, in regulatory processes taking place in the nucleus, and in multimeric protein complexes involved in DNA repair.

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Section: Erp57 On the Cell Surfacementioning

confidence: 99%

Section: Erp57 On the Cell Surfacementioning

confidence: 99%

Section: Erp57 On the Cell Surfacementioning

confidence: 99%

Section: Endoplasmic Reticulummentioning

confidence: 99%

See 2 more Smart Citations

ERp57/GRP58: A protein with multiple functions

Turano

Gaucci

Grillo

et al. 2011

Cellular and Molecular Biology Letters

114

108

View full text Add to dashboard Cite

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“…In chick skeletal muscle cells, this process may involve translocation of the classic nuclear VDR to the cell surface (12) . Alternatively, 1,25(OH) 2 D may bind to a cell surface 1,25(OH) 2 D receptor, Membrane Associated Rapid Response Steroid (16) or to another novel 1,25(OH) 2 D surface receptor (17) . It is agreed that 1,25(OH) 2 D acts at the cell surface to regulate Ca influx by G-protein activation of phospholipase C and adenylate cyclase.…”

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

Serum 25-hydroxyvitamin D and muscle atrophy in the elderly

Dawson‐Hughes

2011

Proc. Nutr. Soc.

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25-hydroxyvitamin D: Vitamin D: Muscle performance: FallsAging is accompanied by loss of muscle mass. Each decade, older women lose an average of 0 . 6 kg lean tissue mass and men lose 1 . 6 kg (1) . Loss of muscle mass results in reduced muscle strength and this, in turn, leads to an increased risk of falling. The term sarcopenia was coined in 1989 by Rosenberg to describe the decline in muscle mass that occurs with aging (2) . Nine years later, Baumgartner operationalised the term to: appendicular skeletal muscle mass (muscle weight (kg)/height 2 (m 2 ) being less than 2 SD below the mean of a young, same-sex reference group (3) . By this definition, the prevalence of sarcopenia increased from 13 to 24% in persons under the age of 70 years to over 50% in persons over the age of 80 years (3) . Moreover, he documented the fact that sarcopenia was significantly associated with self-reported physical disability in both men and women, independent of ethnicity, age, morbidity, obesity, income and health behaviours. This study was influential in drawing attention to the extent of the problem and to its ramifications. More recently, a variety of definitions have been proposed but no one is used by all.Exercise has well-established powerful trophic effects on muscle mass and function. Low intensity selfadministered home-based exercise programmes have lowered risk of falling in elders (4,5) and should always be encouraged. The focus of this paper, however, is on whether vitamin D status affects muscle performance and risk of falling and whether supplementing current intakes of vitamin D may improve muscle performance and lower risk of falling.

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Osteoblast maturation and new bone formation in response to titanium implant surface features are reduced with age

Olivares-Navarrete

Raines

Hyzy

et al. 2012

Journal of Bone and Mineral Research

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The surface properties of materials contribute to host cellular response and play a significant role in determining the overall success or failure of an implanted biomaterial. Rough titanium (Ti) surface microtopography and high surface free energy have been shown to enhance osteoblast maturation in vitro and increase bone formation in vivo. While the surface properties of Ti are known to affect osteoblast response, host bone quality also plays a significant role in determining successful osseointegration. One factor affecting host bone quality is patient age. We examined both in vitro and in vivo whether response to Ti surface features was affected by animal age. Calvarial osteoblasts isolated from 1-, 3-, and 11-month-old rats all displayed a reduction in cell number and increases in alkaline phosphatase specific activity and osteocalcin in response to increasing Ti surface microtopography and surface energy. Further, osteoblasts from the three ages examined displayed increased production of osteocalcin and local factors osteoprotegerin, VEGF-A, and active TGF-β1 in response to increasing Ti surface roughness and surface energy. Latent TGF-β1 only increased in cultures of osteoblasts from 1- and 3-month-old rats. Treatment with the systemic osteotropic hormone 1α,25(OH)2D3 further enhanced the response of osteoblasts to Ti surface features for all three age groups. However, osteoblasts derived from 11-month-old animals had a reduced response to 1α,25(OH)2D3 as compared to osteoblasts derived from 1-or 3-month-old animals. These results were confirmed in vivo. Ti implants placed in the femoral intramedullary canal of old (9-month) mice yielded lower bone-to-implant contract and neovascularization in response to Ti surface roughness and energy compared to younger (2-month) mice. These results show that rodent osteoblast maturation in vitro as well as new bone formation in vivo is reduced with age. Whether comparable age differences exist in humans needs to be determined.

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Protein-disulfide Isomerase-associated 3 (Pdia3) Mediates the Membrane Response to 1,25-Dihydroxyvitamin D3 in Osteoblasts

Cited by 90 publications

References 49 publications

ERp57/GRP58: A protein with multiple functions

ERp57/GRP58: A protein with multiple functions

Serum 25-hydroxyvitamin D and muscle atrophy in the elderly

Osteoblast maturation and new bone formation in response to titanium implant surface features are reduced with age

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