Soil is the basic requirement for agriculture crop production and simultaneously the microbial activity is important to improve soil health for healthy crop growth because microbial communities play an important role in building a complex link between plants and soil. Microbiomes from plants, soil and extreme environments are naturally gifted with amazing capabilities which play significant roles in the maintenance of global nutrient balance and ecosystem functions. The microbiomes from diverse niches have in fact emerged as potential tools for improving the plant growth and productivity by diverse mechanisms include solubilization of nutrients, nitrogen fixation, hormonal stimulation as well as biotic and abiotic stress tolerance. Further, these microbiomes have an immense potential to maintain soil health and fertility. Thus, dependent on their mode of action and effects, these microbiomes can be used as biofertilizers, biopesticides, plant strengtheners, and phytostimulators which will play a major role in improving productivity and achieving sustainability in an eco-friendly, economical and cost effective manner.