Disruption of the anterior–posterior rotator cuff force balance alters joint function and leads to joint damage in a rat model

Reuther, Katherine E.; Thomas, Stephen J.; Tucker, Jennica J.; Sarver, Joseph J.; Gray, Chancellor F.; Rooney, Sarah Ilkhanipour; Glaser, David L.; Soslowsky, Louis J.

doi:10.1002/jor.22586

Cited by 31 publications

(39 citation statements)

References 25 publications

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“…For example, tendon impingement is a leading cause of rotator cuff tendinopathy. Additionally, rotator cuff tears can cause a force imbalance in the shoulder joint, which results in tendinopathy in adjacent rotator cuff tendons [97–99]. Taken together, these data suggest that overuse and abnormal loading may disrupt the homeostatic balance between synthesis and degradation, creating an overall catabolic response and development of disease.…”

Section: Case Study 1: the Extracellular Matrix In The Tendonmentioning

confidence: 99%

The (dys)functional extracellular matrix

Freedman

Bade

Riggin

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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The extracellular matrix (ECM) is a major component of the biomechanical environment with which cells interact, and it plays important roles in both normal development and disease progression. Mechanical and biochemical factors alter the biomechanical properties of tissues by driving cellular remodeling of the ECM. This review provides an overview of the structural, compositional, and mechanical properties of the ECM that instruct cell behaviors. Case studies are reviewed that highlight mechanotransduction in the context of two distinct tissues: tendons and the heart. Although these two tissues demonstrate differences in relative cell–ECM composition and mechanical environment, they share similar mechanisms underlying ECM dysfunction and cell mechanotransduction. Together, these topics provide a framework for a fundamental understanding of the ECM and how it may vary across normal and diseased tissues in response to mechanical and biochemical cues. This article is part of a Special Issue entitled: Mechanobiology.

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Section: Case Study 1: the Extracellular Matrix In The Tendonmentioning

confidence: 99%

The (dys)functional extracellular matrix

Freedman

Bade

Riggin

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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“…In study #1 (Reuther et al, 2014a), animals underwent unilateral detachment of the supraspinatus only (SO) or supraspinatus and infraspinatus (SI) rotator cuff tendons, and ambulatory measurements were collected up to 8 weeks post-operatively. To create a more general model, data from the SO and SI groups were combined and used for the correlation and regression analysis in the current study as significant differences between these groups were observed in shoulder function (as measured by kinetic gait parameters), as well as tendon and cartilage mechanical and histological properties.…”

Section: Methodsmentioning

confidence: 99%

Ground reaction forces are more sensitive gait measures than temporal parameters in rodents following rotator cuff injury

Pardes

Freedman

Soslowsky

2016

Journal of Biomechanics

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Gait analysis is a quantitative, non-invasive technique that can be used to investigate functional changes in animal models of musculoskeletal disease. Changes in ground reaction forces following injury have been observed that coincide with differences in tissue mechanical and histological properties during healing. However, measurement of these kinetic gait parameters can be laborious compared to the simpler and less time-consuming analysis of temporal gait parameters alone. We compared the sensitivity of temporal and kinetic gait parameters in detecting functional changes following rotator cuff injury in rats. Although these parameters were strongly correlated, temporal measures were unable to detect greater than 50% of the functional gait differences between injured and uninjured animals identified simultaneously by ground reaction forces. Regression analysis was used to predict ground reaction forces from temporal parameters. This model improved the ability of temporal parameters to identify known functional changes, but only when these differences were large in magnitude (i.e., between injured vs. uninjured animals, but not between different post-operative treatments). The results of this study suggest that ground reaction forces are more sensitive measures of limb/joint function than temporal parameters following rotator cuff injury in rats. Therefore, although gait analysis systems without force plates are typically efficient and easy to use, they may be most appropriate for use when major functional changes are expected.

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“…Overuse activity was modeled as stated in our previous publications. 18, 24 Initially, rats in overuse groups underwent a 2-week treadmill training period to acclimate them to running at the desired speed and for the desired duration. All groups then underwent unilateral surgical transection (or sham transection) of the spinal accessory and long thoracic nerves, resulting in denervation of the trapezius and serratus anterior muscles, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…18 Briefly, stain lines, for local optical strain measurements, were placed on the biceps and supraspinatus tendons, dividing the insertion and mid-substance regions. The scapula and humerus were embedded using polymethymethacrylate (PMMA) and secured in a custom testing fixture.…”

Section: Methodsmentioning

confidence: 99%

Overuse Activity in the Presence of Scapular Dyskinesis Leads to Shoulder Tendon Damage in a Rat Model

et al. 2014

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Shoulder tendon injuries are common clinical conditions and are a significant source of pain and dysfunction. These conditions are more common in individuals who perform repetitive overhead activities and in individuals who have abnormal scapular kinematics, termed scapular dyskinesis (SD). However, the long term consequences associated with overuse activity in the presence of SD are unknown. Therefore, the objective of this study was to determine the effect of overuse in combination with SD on joint mechanics and properties of the rotator cuff and biceps tendons. A rat model of scapular dyskinesis was used. 90 adult male Sprague-Dawley rats (400–450 grams) were randomized into three groups: nerve transection (SD), sham nerve transection + overuse (OV), or nerve transection + overuse (SD + OV). Rats were sacrificed at 2, 4, and 8 weeks after surgery. Shoulder function and passive joint mechanics were evaluated over time and tendon properties (mechanical, histological, organizational, and compositional) were measured. Results demonstrated that overuse activity and SD are each independently detrimental to tendon properties (e.g., diminished mechanical properties, disorganized collagen). However, tendon damage caused by the addition of overuse may be worse, with more parameters altered, than damage caused by the addition of SD. This study helps define the mechanical mechanisms leading to tendon damage and provides a framework for distinguishing treatment strategies for active patients and those with abnormal scapular mechanics.

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Disruption of the anterior–posterior rotator cuff force balance alters joint function and leads to joint damage in a rat model

Cited by 31 publications

References 25 publications

The (dys)functional extracellular matrix

The (dys)functional extracellular matrix

Ground reaction forces are more sensitive gait measures than temporal parameters in rodents following rotator cuff injury

Overuse Activity in the Presence of Scapular Dyskinesis Leads to Shoulder Tendon Damage in a Rat Model

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