Disruption of the blood-aqueous barrier following paracentesis in the rabbit

Unger, W.G.; Cole, David; Hammond, B. R.

doi:10.1016/0014-4835(75)90139-6

Cited by 91 publications

(65 citation statements)

References 28 publications

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“…In the iridial processes, the basolateral labyrinth immediately becomes enlarged and filled with protein when the IOP drops or the eye is injured. 'Blister-like vacuoles between the epithelial layers' [22], stromal edema and cellular distortion have already been described by previous authors, following paracentesis or treatment with prostaglandin E2 [14,22]. As shown here, however, this 'vacuolization' is, in fact, an enlargement of the intercellular spaces of the basolateral labyrinth which is reversible at any stage of the process.…”

Section: Discussionsupporting

confidence: 77%

Functional Morphology of Rabbit Iridial Ciliary Processes

Funk¹

1989

Ophthalmic Res

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Using scanning electron microscopy of vascular resin casts, it was found that the capillary network of the iridial ciliary processes is supplied by arterioles of its own and drained posteriorly by long isolated venules. These venules pass the ciliary body without greater connection to the venules of the major ciliary processes (shunt-system). Transmission electron microscopy showed that in contrast to the pigment epithelium (PE) of the major ciliary processes, the PE of the iridial processes develops elongated finger-like cytoplasmic processes which protrude into the stroma, often in the direction of the vessels, forming a ‘basolateral labyrinth’, like the kidney tubule epithelium. After paracentesis, an enlargement and leakage of the iridial ciliary process capillaries was found, resulting in resin leakage at various sites; no leakage was found in the vasculature of the major ciliary processes. Electron microscopically, the basolateral labyrinth of the PE appeared enormously enlarged, forming wide protein-containing intercellular spaces. These findings suggest that the function of the iridial ciliary processes in rabbits has a dual nature. Under normal circumstances, the main function of the iridial processes may be fluid reabsorption rather than aqueous humor secretion. In cases of paracentesis, for example, the very sensitive blood aqueous barrier of this area breaks down with resulting protein exudation.

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Section: Discussionsupporting

confidence: 77%

Functional Morphology of Rabbit Iridial Ciliary Processes

Funk¹

1989

Ophthalmic Res

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“…PG seems cer tain to be an important mediator of this re sponse since (1) it appears in the aqueous following laser stimulation of the iris, (2) exogenous E-type PG can elicit a qualita tively similar pattern of events [Ambache et al, 1965;Waitzman and King, 1967;Unger et al, 1975], and (3) a therapeutic dose of indomethacin [a PG synthetase in hibitor; Vane, 1971] is inhibitory. How ever, E-type PG is not very miotic [Beitch and Eakins, 1969] and indomethacin has only a limited effect on the miosis induced by irradiation.…”

Section: Discussionmentioning

confidence: 99%

“…By using an excitor filter (Balzer F1TC3) and barrier filler (Ilford 110), fluorescence of the dye could be recorded on Tri-X film (Kodak, London). |See further details in Unger et al, 1975.1…”

Section: Fluorescein a Ngiographymentioning

confidence: 99%

Prostaglandin and Nerve-Mediated Response of the Rabbit Eye to Argon Laser Irradiation of the Iris

Unger¹,

Bass²

1977

Ophthalmologica

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“…Prostalandins have the following effects upon the eye: miosis, rise of intraocular pressure, vasodilation in iris and ciliary body, breakdown of blood-aqueous barrier and cystoid macular edema (Cole and Unger, 1973;Easty et al, 1977;Neufeld and Sears, 1973;Podos and Becker, 1976;Unger et al, 1975). Indomethacin, belonging to the group of prostaglandin inhibitors, is claimed to diminish these effects after the posttraumatic (surgical) release of prostaglandin E and F2a (Bhattacherjee and Eakins, 1974;Eakins, 1977;Katz, 1981).…”

Section: Introductionmentioning

confidence: 99%

Indomethacin eyedrops and the postoperative irritation after extracapsular cataract extraction combined with intraocular lens implantation

1983

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Indomethacin 0.5% solution eyedrops inhibit the prostaglandin effects after extracapsular cataract extraction combined with intraocular lens implantation. In a double-blind study Indomethacin was compared to Dexamethason and placebo using corneal thickness and iris vessel dilatation and leakage as parameters for postoperative irritation. The present evidence indicates that Indomethacin is an important additive medication to diminish the postoperative reaction.

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Disruption of the blood-aqueous barrier following paracentesis in the rabbit

Cited by 91 publications

References 28 publications

Functional Morphology of Rabbit Iridial Ciliary Processes

Functional Morphology of Rabbit Iridial Ciliary Processes

Prostaglandin and Nerve-Mediated Response of the Rabbit Eye to Argon Laser Irradiation of the Iris

Indomethacin eyedrops and the postoperative irritation after extracapsular cataract extraction combined with intraocular lens implantation

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