Disruption of the permeability barrier (zonula occludens) between intestinal epithelial cells by lethal doses of endotoxin

Walker, Richard I.; Porvaznik, Martin

doi:10.1128/iai.21.2.655-658.1978

Cited by 58 publications

(1 citation statement)

References 13 publications

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“…In conditions of severe or complete intestinal barrier failure, translocating bacteria invade mesenteric lymph nodes, systemic organs, and the circulatory system [29]. Severe compromise of barrier gut function is found in malnutrition of the gastrointestinal tract, mostly when additional factors are present, such as hemorrhagic shock [37], sepsis [38], trauma [39], cytotoxic chemotherapy [40], endotoxemia [41], and the radical-free state during reperfusion [42]. Most of the studies on gut barrier function and the consequences of its disruption-sepsis and multisystem organ failure (MSOF)-were primarily laboratory experiments with animal models [29].…”

Section: Gastrointestinal Tractmentioning

confidence: 99%

Malnutrition: Organic and Functional Consequences

Mora

1999

World j. surg.

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Malnutrition in its various forms is without doubt the commonest disease. Acute malnutrition resulting from a total lack of ingestion clearly shows that not only are water and electrolytes a priority for survival but also energy reserves. It also shows that the maximum wasting that the lean body mass can withstand is around 40% before the organism collapses and death occurs. Malnutrition is more often the results of insufficient ingestion, and the term protein-calorie malnutrition has been suggested for the most frequently occurring type. This can give rise to confusion because the deficiency in these patients is not limited to these macronutrients but extends, rather, to micronutrients, which are equally important to the functioning of the body. A useful approach for the surgeon is to analyze how the various organs and systems have been affected. The effects on the gastrointestinal tract, the immunologic system, and formation of scar tissue are reviewed.

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Section: Gastrointestinal Tractmentioning

confidence: 99%

Malnutrition: Organic and Functional Consequences

Mora

1999

World j. surg.

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Endotoxin Promotes the Translocation of Bacteria From the Gut

Deitch¹

1987

Arch Surg

372

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Bacterial Translocation After Major Hepatectomy in Patients and Rats

Wang

Andersson²,

Soltesz³

et al. 1992

Arch Surg

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Bacterial infections are frequent complications after liver resection. Of 138 patients who underwent major hepatectomy, 11 patients (8%) developed intra-abdominal sepsis in the postoperative period. Seven bacterial strains of gut origin were isolated from the abdominal cavity. Eight patients had multiple bacteria cultured. In the experimental studies on rat models, positive mesenteric lymph node cultures were seen 2 hours after removal of 70% and 90% of the total weight of the rat liver, and 12 hours after 50% hepatectomy, persisting for 3 and 4 days after 50% and 70% hepatectomy, respectively. The incidences of bacteremia 2 and 4 hours after 90% hepatectomy were 80% and 100%, respectively; 6 hours after 70% liver resection, the incidence of bacteremia was 33%. Blood cultures were positive in only 6% of the rats following 50% hepatectomy, and in none of the controls. Thus, bacterial translocation occurs in the early course after hepatectomy, the incidence being proportional to the amount of liver tissue removed.

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Disruption of the permeability barrier (zonula occludens) between intestinal epithelial cells by lethal doses of endotoxin

Cited by 58 publications

References 13 publications

Malnutrition: Organic and Functional Consequences

Malnutrition: Organic and Functional Consequences

Endotoxin Promotes the Translocation of Bacteria From the Gut

Bacterial Translocation After Major Hepatectomy in Patients and Rats

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