Dissecting the functional role of microRNA 21 in osteosarcoma

Sekar, Durairaj; Prabaharan, M.; Biruntha, Muniyandi; Sivagurunathan, Periyasamy; Karthigeyan, M

doi:10.1038/s41417-019-0092-z

Cited by 65 publications

(57 citation statements)

References 32 publications

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“…It has been suggested that miRNAs are involved in many biological processes, including proliferation, migration, invasion differentiation, and apoptosis (Giuliani et al, 2017;Panagal et al, 2018Panagal et al, , 2019. Despite miRNAs being involved in several diseases and their role been clearly delineated (Sekar et al, 2019a(Sekar et al, , 2019b, up to our knowledge, publications related to miRNAs in mitochondria and its related diseases are very less; we summarize hereunder some of the research evidence from those published articles.…”

Section: Relationship Of Mirnas In Mitochondrial Diseases and Dysfuncmentioning

confidence: 94%

“…The evolution of miRNAs in the past two decades emerged as a key regulator of gene expression that controls physiological pathological cellular differentiation processes and metabolic homeostasis (Sekar et al, 2016a(Sekar et al, , 2016bSekar et al, 2019aSekar et al, , 2019b. miRNAs are a potential biomarker in both communicable and noncommunicable diseases.…”

Section: Introductionmentioning

confidence: 99%

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Biological and Clinical Relevance of microRNAs in Mitochondrial Diseases/Dysfunctions

Sekar

Johnson

Biruntha

et al. 2020

DNA and Cell Biology

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Mitochondrial dysfunction arises from an inadequate number of mitochondria, an inability to provide necessary substrates to mitochondria, or a dysfunction in their electron transport and a denosine triphosphate synthesis machinery. Occurrences of mitochondrial dysfunction are due to genetic or environmental changes in the mitochondria or in the nuclear DNA that codes mitochondrial components. Currently, drug options are available, yet no treatment exists in sight of this disease and needs a new insight into molecular and signaling pathways for this disease. microRNAs (miRNAs) are small, endogenous, and noncoding RNAs function as a master regulator of gene expression. The evolution of miRNAs in the past two decades emerged as a key regulator of gene expression that controls physiological pathological cellular differentiation processes, and metabolic homeostasis such as development and cancer. It has been known that miRNAs are a potential biomarker in both communicable and noncommunicable diseases. But, in the case of mitochondrial dysfunction in miRNAs, the number of studies and investigations are comparatively less than those on other diseases and dysfunctions. In this review, we have elaborated the roles of miRNAs in the mitochondrial diseases and dysfunctions.

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Section: Relationship Of Mirnas In Mitochondrial Diseases and Dysfuncmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Biological and Clinical Relevance of microRNAs in Mitochondrial Diseases/Dysfunctions

Sekar

Johnson

Biruntha

et al. 2020

DNA and Cell Biology

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“…The expression of miR-124 [22] and miR-7 [23] was decreased in the progression of OS. On the contrary, some publications found that the expression of miR-106b [24] and miR-21 [25] elevated in patients with OS. Additionally, the expression and clinical association of miR-455-3p were also revealed in many kinds of malignant cancers.…”

Section: Discussionmentioning

confidence: 92%

MiR-455-3p downregulation facilitates cell proliferation and invasion and predicts poor prognosis of osteosarcoma

2020

J Orthop Surg Res

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Background Osteosarcoma (OS) is one of the most primary malignant bone tumors, mainly attracting children and young adults. The microRNAs are mentioned to play vital roles in many cancers, including OS. The purpose of this study was to explore the expression and function of miR-455-3p in OS and predict the potential effects in clinical diagnosis and prognosis. Method We conducted quantitative real-time PCR to assess the expression of miR-455-3p in OS tissues and cell lines. The Cell Counting Kit-8 assay, Transwell assay, and flow cytometry were performed to assess the ability of miR-455-3p on cell proliferation, migration, invasion, and apoptosis. Kaplan–Meier curve and Cox regression analysis were used to demonstrate the survival outcome. Results This study revealed that the expression of miR-455-3p was decreased in OS tissues and cell lines. The dysregulation of miR-455-3p was in association with tumor size, distant metastasis, and clinical stage. Patients with high miR-455-3p expression had a satisfying survival rate. Multivariate Cox analysis indicated that miR-455-3p was a promising prognostic indicator. Expression of miR-455-3p could inhibit the proliferation, migration, and invasion, and facilitate apoptosis of OS cells in vitro. Conclusion These results indicated the miR-455-3p was a potential clinical therapeutic target and prognostic biomarker by suppressing the proliferation, migration, and invasion, as well as enhancing cell apoptosis.

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“…Considering the poor prognosis of advanced CCA, the present study aimed to improve CCA outcomes through the assessment of a miRNA considered to be an independent prognostic factor. A number of studies have demonstrated that miRNAs are abnormally expressed in various cancer types, such as non-small cell lung (23), bladder (24) and colorectal (25) cancer and osteosarcoma (26), and have broad potential for use as diagnostic or/and prognostic markers and therapeutic targets for cancer treatment (27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Overexpression of microRNA‑96 is associated with poor prognosis and promotes proliferation, migration and invasion in cholangiocarcinoma cells via MTSS1

Yin

Chai

Sun³

et al. 2020

Exp Ther Med

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MicroRNA-96 (miR-96) has been revealed serve an oncogenic role in various types of cancer. However, the role of miR-96 in cholangiocarcinoma (CCA) development and progression is yet to be elucidated. Thus, the aim of the present study was to investigate the role of miR-96 in CCA. The expression pattern of miR-96 in CCA tissues and cell lines was evaluated using reverse transcription-quantitative PCR analysis. Kaplan-Meier curves and Cox regression analyses were conducted to investigate the prognostic significance of miR-96 in CCA. Cell Counting Kit-8 and Transwell assays were performed to identify the functions of miR-96. The association between miR-96 and metastasis suppressor-1 (MTSS1) was verified using a dual-luciferase assay. The results demonstrated that miR-96 expression levels were increased in CCA tissues and cell lines compared with those in adjacent normal tissues and normal human intrahepatic biliary epithelial cell lines, respectively. High expression levels of miR-96 were significantly associated with lymph node metastasis, differentiation and TNM stage. In addition, upregulated expression of miR-96 was associated with a poorer prognosis and was predicted to be a prognostic factor in patients with CCA. Overexpression of miR-96 in vitro promoted CCA cell proliferation, migration and invasion. Additionally, MTSS1 was identified as a direct target of miR-96. The results of the present study indicated the clinical and biological importance of miR-96 as an oncogene in CCA. miR-96 may represent an independent prognostic biomarker and may promote CCA cell proliferation, migration and invasion by targeting MTSS1.

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Dissecting the functional role of microRNA 21 in osteosarcoma

Cited by 65 publications

References 32 publications

Biological and Clinical Relevance of microRNAs in Mitochondrial Diseases/Dysfunctions

Biological and Clinical Relevance of microRNAs in Mitochondrial Diseases/Dysfunctions

MiR-455-3p downregulation facilitates cell proliferation and invasion and predicts poor prognosis of osteosarcoma

Overexpression of microRNA‑96 is associated with poor prognosis and promotes proliferation, migration and invasion in cholangiocarcinoma cells via MTSS1

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