Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic–pituitary–adrenal axis by gene targeting in mice

Laryea, Gloria; Muglia, Lisa M.; Arnett, Melinda G.; Muglia, Louis J.

doi:10.1016/j.yfrne.2014.09.002

Cited by 45 publications

(29 citation statements)

References 216 publications

(261 reference statements)

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“…prior to LPS injection increased circulating glucocorticoids (vehicle-LPS: 1,072.0 ± 130.60 ng/ml vs. MF-LPS: 2,109.0 ± 357.80 ng/ml, n = 6; fig. 3e), confirming the impairment of the well-known GR-dependent negative feedback on the hypothalamic-pituitary-adrenal axis [44]. Interestingly, GR blockade increased the nocturnal levels of melatonin after LPS treatment (vehicle-LPS: 62.5 ± 3.07 vs. MF-LPS: 72.4 ± 1.26 pg/ml; fig.…”

Section: Resultssupporting

confidence: 63%

Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis

et al. 2016

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Background/Aim: The nocturnal production of melatonin by the pineal gland is triggered by sympathetic activation of adrenoceptors and may be modulated by immunological signals. The effect of glucocorticoids on nocturnal melatonin synthesis is controversial; both stimulatory and inhibitory effects have been reported. During pathophysiological processes, an increased sympathetic tonus could result in different patterns of adrenoceptor activation in the pineal gland. Therefore, in this investigation, we evaluated whether the pattern of adrenergic stimulation of the pineal gland drives the direction of the glucocorticoid effect on melatonin production. Methods: The corticosterone effect on the pineal hormonal production induced by β-adrenoceptor or β+α₁-adrenoceptor activation was evaluated in cultured glands. We also investigated whether the in vivo lipopolysaccharide (LPS)-induced inhibition of melatonin is dependent on the interaction of glucocorticoids and the α₁-adrenoceptor in adrenalectomized animals and on the in vivo blockade of glucocorticoid receptors (GRs) or the α₁-adrenoceptor. Results: Corticosterone potentiated β-adrenoceptor-induced pineal melatonin synthesis, whilst corticosterone-dependent inhibition was observed when melatonin production was induced by β+α₁-adrenoceptors agonists. The inhibitory effect of corticosterone is mediated by GR, as it was abolished in the presence of a GR antagonist. Moreover, LPS-induced reduction in melatonin nocturnal plasma content was reversed by adrenalectomy and by antagonizing GR or α₁-adrenoceptors. Conclusions: The dual effect of corticosterone on pineal melatonin synthesis is determined by the activation pattern of adrenoceptors (β or β+α₁) in the gland during GR activation, suggesting that increased activation of the sympathetic system and the hypothalamic-pituitary-adrenal axis are necessary for the control of melatonin production during defense responses.

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Section: Resultssupporting

confidence: 63%

Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis

et al. 2016

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“…Together these studies support a functional role for the GR in HPA function [reviewed in Laryea, Muglia, Arnett, & Muglia (2015)], cognition and anxiety modulation. That said, the different genetic approaches used to create these transgenic strains, behavioral methodology, gender, and timing of these manipulations appear to be confounding factors and make widespread interpretation of these studies difficult.…”

Section: Use Of Genetically Modified Rodent Strains To Discern Gc Recsupporting

confidence: 55%

Mineralocorticoid and glucocorticoid receptor-mediated control of genomic responses to stress in the brain

Mifsud

Reul

2018

Stress

105

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“…Stress, a physiological response to an environmental demand, usually activates a specific neuroendocrine pathway known as the hypothalamic-pituitary-adrenal (HPA) axis and increases corticosterone [5,39]. Many studies have reported that elevated corticosterone concentrations contributed to stress-induced impairments in cognitive and learning abilities [8].…”

Section: Discussionmentioning

confidence: 99%

Protective effect of the orientin on noise-induced cognitive impairments in mice

Wang

Feng

et al. 2016

Behavioural Brain Research

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There is increasing evidence that chronic noise stress impairs cognition and induces oxidative stress in the brain. Recently, orientin, a phenolic compound abundant in some fruits, millet, and herbs, has been shown to have antioxidant properties. This study investigated the potential effects of orientin against chronic noiseinduced cognitive decline and its underlying mechanisms. A moderate-intensity noise exposure model was used to investigate the effects of orientin on behavior and biochemical alterations in mice. After 3 weeks of the noise exposure, the mice were treated with orientin (20 mg/kg and 40 mg/kg, oral gavage) for 3 weeks. The chronic noise exposure impaired the learning and memory in mice in the Morris water maze and step-through tests. The noise exposure also decreased exploration and interest in a novel environment in the open field test. The administration of orientin significantly reversed noise-induced alterations in these behavior tests. Moreover, the orientin treatment significantly improved the noise-induced alteration of serum corticosterone and catecholamine levels and oxidative stress in the hippocampus and prefrontal cortex. Furthermore, the orientin treatment ameliorated the noise-induced decrease in brain-derived neurotrophic factor and synapseassociated proteins (synaptophysin and postsynaptic density protein 95) in the hippocampus and prefrontal cortex. Thus, orientin exerts protective effects on noise-induced cognitive decline in mice, specifically by improving central oxidative stress, neurotransmission, and increases synapse-associated proteins. Therefore, supplementation with orientin-enriched food or fruit could be beneficial as a preventive strategy for chronic noise-induced cognitive decline. Disciplines Medicine and Health Sciences Publication DetailsWang, S., Yu, Y., Feng, Y., Zou, F., Zhang, X., Huang, J., Zhang, Y., Zheng, X., Huang, X., Zhu, Y. & Liu, Y. (2016). Protective effect of the orientin on noise-induced cognitive impairments in mice. Behavioural Brain Research, 296 290-300.

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Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic–pituitary–adrenal axis by gene targeting in mice

Cited by 45 publications

References 216 publications

Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis

Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis

Mineralocorticoid and glucocorticoid receptor-mediated control of genomic responses to stress in the brain

Protective effect of the orientin on noise-induced cognitive impairments in mice

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