Disseminated Encephalomyelitis

Fundamental Problems in the Pathology of Multiple Sclerosis and Allied Demyelinating Diseases

“…It is the entitative character, then, of the 95 % of classical multiple sclerosis that has to be explained by any acceptable hypothesis of causation. Far from reproducing this entitative character in 95 % of the lesions they cause, the agencies so far blamed for multiple sclerosis-such as spirochaetes and neurotropic viruses (e.g., Bailey et al, 1949), thrombosis (Putnam, 1933(Putnam, , 1935(Putnam, , 1937Putnam and Alexander, 1939), or lead-poisoning (Campbell et al, 1950)-can only very rarely produce any lesions which even mimic multiple sclerosis.…”

On the Historical Succession of Vessel-Based Therapies in the Treatment of Multiple Sclerosis

“…Putnam highlighted the histological association of disseminated encephalomyelitis with cerebral small-vessel thrombi [27], and phenomenological similarities between acute disseminated encephalomyelitis and MS [28]. He postulated that encephalomyelitis may be the acute stage in the pathological development towards chronic relapsing MS [29].…”

Capillary Fat‐embolism in the Brains of Sheep, Pigs and Monkeys, With Especial Reference to Demyelination and Other Lesions in the White Matter

“…On the whole it appears unlikely that the lesions they produced really tallied with those in naturally occurring human diseases. In disseminated sclerosis and disseminated encephalomyelitis, Putnam (1936Putnam ( , 1937, Putnam and Alexander (1939) and Scheiriker (1943) emphasized the occurrence of thrombi in tbe smaller veins aud saw in the phenomenon the basis for the demyelination. Simon and Solomon (1935) and Simon (1942) found in disseminated sclerosis an increased coa^ilability of tbe blood when the patients received injections of adrenalin or typhoid vaccine.…”