Disseminated Eruptive Clear Cell Acanthoma With Spontaneous Regression: Further Evidence of an Inflammatory Origin?

García‐Gavín, J.; González‐Vilas, D.; Montero, Iria; Rodríguez-Pazos, L.; Pereiro, Maria Mercedes; Toribio, Jaime

doi:10.1097/dad.0b013e3181f078e0

Cited by 26 publications

(19 citation statements)

References 16 publications

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“…In fact, it is generally considered to be a benign epidermal neoplasm, although some authors are in favor of describing it as a reactive inflammatory hyperplasia. 1,5 …”

Section: Introductionmentioning

confidence: 99%

Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma

Scanni¹,

Pellacani

2014

An. Bras. Dermatol.

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Although uncommonly diagnosed, clear cell acanthoma represents an original source of speculative interest for dermatologists. Due to its clinical variability, it is often only recognized accidentally after histology. Dermoscopy has improved the reliability of clinical diagnosis of typical clear cell acanthoma thanks to the vascular pinpoint pattern and desquamative, peripheral collarette. Generally, therapy of clear cell acanthoma is oriented towards ablative solutions, such as surgery or cryotherapy. We propose a conservative therapy, based on the application of topical calcipotriol, which has produced complete regression after 2 months and no relapse one year after the end of treatment. A dermatoscope monitored all changes of clear cell acanthoma, showing its utility not only in diagnosis but also in therapeutic follow-up. This new therapeutic approach should support an inflammatory etiology of clear cell acanthoma, although further observations are needed to confirm this.

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“…In fact, it is generally considered to be a benign epidermal neoplasm, although some authors are in favor of describing it as a reactive inflammatory hyperplasia. 1,5 …”

Section: Introductionmentioning

confidence: 99%

Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma

Scanni¹,

Pellacani

2014

An. Bras. Dermatol.

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“…4,6 A recent observation of histologically proven spontaneous regression in a case of CCA with multiple lesions also reinforces this theory. 5 For all these reasons, the pathologic nature of CCA still remains under debate. …”

Section: Discussionmentioning

confidence: 99%

“…4 Rare disseminated forms must be differentiated from other eruptive dermatoses such as guttate psoriasis, certain forms of parapsoriasis, sarcoidosis, lichen planus, and granuloma annulare. 5 …”

mentioning

confidence: 99%

Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases*

Veiga

Barros²,

Santos³

et al. 2013

An. Bras. Dermatol.

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Clear cell acanthoma or Degos' acanthoma is a distinct disease concerning its clinical, histopathological, and immunohistochemical features. Its pathologic nature - whether neoplastic or reactive - is still under dispute among researchers. The disease shows a chronic course and often presents with a single papulonodular lesion on the lower limbs of adults. However, cases with multiple lesions, sometimes occurring in an eruptive fashion, and with clear variation in the size and shape of the cutaneous lesions have been reported. So far, five cases in which the lesions were exclusively located in the nipple area have been reported, all in Korean women. Four of these cases mimicked eczema and one, a polypoid nodule. The aim of this article is to present clinical, histopathological, and immunohistochemical features of two additional cases in Brazilian women with similar nipple topography.

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“…Eruptive CCA or ‘eruptive hamartomatous CCA’ is a term that has been used in cases where there are multiple CCAs (usually > 20–30 lesions) 10,41 . To date, > 25 cases have been reported 42,43 .…”

Section: Clinical Presentation and Variantsmentioning

confidence: 99%

Clear cell acanthoma

Tempark

Shwayder

2012

Clinical and Experimental Dermatology

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SummaryClear cell acanthoma (CCA), is an asymptomatic benign lesion of unknown origin and aetiology, which typically presents as a red to brown, dome-shaped papule on the leg. We discuss the case of a patient with an irregular plaque of hypopigmented papules whose diagnosis of CCA was only made by biopsy, and review the characteristic presentation, uncommon variants, locations and associated conditions of this lesion. The diagnosis is based on histopathology and ⁄ or immunohistochemistry, but the variable clinical presentation may make diagnosis difficult. The differential diagnosis includes skin tumours and inflammatory and pigmentary dermatoses. The lesions do not regress spontaneously, and excisional removal is the preferred treatment.

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Disseminated Eruptive Clear Cell Acanthoma With Spontaneous Regression: Further Evidence of an Inflammatory Origin?

Cited by 26 publications

References 16 publications

Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma

Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma

Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases*

Clear cell acanthoma

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