Disseminated histoplasmosis

Abstract

Disseminated histoplasmosis is a relentlessly progressive granulomatous disease which can mimic many other granulomatous diseases including tuberculosis. A 48-year-old male was referred to us with 11 months history of multiple subcutaneous swellings and ulcerations over the upper and lower limbs and fever for 2 months. He was evaluated outside for several months and received anti tubercular drugs for about 2 years in the past for a granulomatous infection of bone and soft tissue identified by various biopsies, without any improvement. When he was evaluated and fresh biopsies were taken, they were stained for fungus and disseminated histoplasmosis was detected. This case confirms the importance of considering fungal infections as a possibility while treating disseminated granulomatous infections, even in immune-competent patients, especially if response to treatment is inadequate.

Infectious sources of Histoplasmosis and molecular techniques for its identification

“…Similarly, the microconidia are tiny about 2 -4 µm in diameter and are more infectious when compared to the more abundant conidia. However, the procedure of culturing is timeconsuming [28]. Likewise, histopathological examination is another technique for detection of the Histoplasma.…”

Potential role of 18 F-2-fluoro-2-deoxy-glucose positron emission tomography/computed tomography imaging in patients presenting with generalized lymphadenopathy

“…The clinical spectrum of the disease ranges from an asymptomatic infection, an acute or chronic pulmonary infection, mediastinal fibrosis or disseminated histoplasmosis. [ 27 ] A chronic infection caused by the organism often results in a diagnostic dilemma due to the resemblance with other chronic diseases. The clinical and imaging features of chronic pulmonary histoplasmosis resemble reactivation of pulmonary TB (with hilar or mediastinal lymphadenopathy and diffuse reticulonodular infiltrates/cavitation in the lungs).…”

Oxidation of Some Methoxy Anilines by Tetrabutylammoniumbromochromate in Aqueous Acetic Acid Medium: A Kinetics Study

“…Corey in his novel attempt to establish pyridiniumchlorochromate [3] as a versatile oxidant, revisited Sarett's reagent and discovered it to be pyridinium dichromate [4]. Significant improvements are achieved in the development of new Cr(VI) based oxidizing agents, such as pyridiniumfluorochromate [5], benzimidazoliumfluorochromate [6], tetrahexylammoniumbromochromate [6], triethylammoniumchlorochromate [7], tetraethyl ammonium bromochromate [9], tetraethylammoniumchlorochromate [10] and tetrabutylammoniumbromochromate [11].…”