Disseminated Histoplasmosis Presenting as Urinary Tract Obstruction in a Renal Transplant Recipient

Superdock, Keith; Dummer, J. Stephen; Koch, Michaël; Gilliam, David M.; Buren, D. H. Van; Nylander, William; Richie, Robert E.; MacDonell, Robert C.; Johnson, Howard; Helderman, J. Harold

doi:10.1016/s0272-6386(12)80386-6

Cited by 18 publications

(14 citation statements)

References 13 publications

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“…Along these lines, CD4 + T lymphocytopenia may be risk factor as well, but this has not been well characterized. This is in accord with observations from transplant experiences, in which Histoplasma infections appear to be related to immune suppression involving steroids, which suppresses both T cell, monocyte, and macrophage function [28][29][30][31][32]. However, even transplant-related Histoplasma infection is a relatively uncommon event, because long-term followup analysis involving 1283 patient-years of data in an area of endemicity near Indianapolis, Indiana, did not show any infections [20].…”

supporting

confidence: 90%

Disseminated Histoplasmosis in Persons with Interferon- Receptor 1 Deficiency

Zerbe

Holland

2005

Clinical Infectious Diseases

149

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Mutations in the interferon (IFN)-gamma receptor predispose to infection with bacille Calmette-Guérin, nontuberculous mycobacteria, and Salmonella organisms. We identified a patient with recurrent disseminated Histoplasma capsulatum osteomyelitis who had an autosomal dominant form of IFN-gamma receptor 1 deficiency (i.e., a 4-bp deletion at or near base 818). IFN-gamma-mediated immunity is important in the control of histoplasmosis.

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supporting

confidence: 90%

Disseminated Histoplasmosis in Persons with Interferon- Receptor 1 Deficiency

Zerbe

Holland

2005

Clinical Infectious Diseases

149

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“…has been used for diagnosis in several reported cases of CNS histoplasmosis [12][13][14][15][16]. The antigen test assisted in the diagnosis of CNS histoplasmosis in both of the cases reported here.…”

Section: Discussionmentioning

confidence: 97%

Diagnosis and Management of Central Nervous System Histoplasmosis

Wheat¹,

Musial²,

Jenny-Avital

2005

Clinical Infectious Diseases

175

144

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Two cases of Histoplasma meningitis are presented, illustrating the difficulty in diagnosis and treatment. The first case occurred in a patient with acquired immunodeficiency syndrome as a relapse of disseminated histoplasmosis and resolved after prolonged treatment and ongoing antiretroviral therapy. The second case occurred in a cardiac allograft recipient as meningitis and focal brain lesions that responded to liposomal amphotericin B, but the patient died shortly after therapy was completed. Unfortunately, there are no prospective studies addressing the diagnosis and management of patients with histoplasmosis of the central nervous system from which to provide evidence-based guidelines for care. In the absence of such data, an approach will be presented on the basis of our experience and opinions.

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“…Disease may develop due to the reactivation of latent lesions or from new exposure in zones where Histoplasma is endemic (286,354,401), but transmission of histoplasmosis from donor to recipient via graft has also been described (227).…”

Section: Infections Caused By Histoplasma Capsulatummentioning

confidence: 99%

“…Pulmonary involvement is common, and immunosuppressed patients can develop severe life-threatening pneumonia, although other varied manifestations have been observed in transplant patients (48,125,259,354,401,414). In this respect, the presentation and clinical course of histoplasmosis in the SOT population appear to be somewhat less severe than histoplasmosis in the AIDS population (393).…”

Section: Infections Caused By Histoplasma Capsulatummentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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SUMMARY In recent years, the increasing number of donors from different regions of the world is providing a new challenge for the management and selection of suitable donors. This is a worldwide problem in most countries with transplantation programs, especially due to the increase in immigration and international travel. This paper elaborates recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients. For this purpose, an extensive review of the medical literature focusing on viral, fungal, and parasitic infections that could be transmitted during transplantation from donors who have lived or traveled in countries where these infections are endemic has been performed, with special emphasis on tropical and imported infections. The review also includes cases described in the literature as well as risks of transmission during transplantation, microbiological tests available, and recommendations for each infection. A table listing different infectious agents with their geographic distributions and specific recommendations is included.

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Disseminated Histoplasmosis Presenting as Urinary Tract Obstruction in a Renal Transplant Recipient

Cited by 18 publications

References 13 publications

Disseminated Histoplasmosis in Persons with Interferon- Receptor 1 Deficiency

Disseminated Histoplasmosis in Persons with Interferon- Receptor 1 Deficiency

Diagnosis and Management of Central Nervous System Histoplasmosis

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

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