Disseminated Intravascular Coagulation and Head Injury

Sibinga, C. Th. Smit; Vecht, C J

doi:10.1007/978-1-4613-4337-0_67

Microcirculation 1976

DOI: 10.1007/978-1-4613-4337-0_67

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Disseminated Intravascular Coagulation and Head Injury

C. Th. Smit Sibinga¹,

C J Vecht²

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1978

1979

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Cited by 2 publications

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Disturbances of the coagulatory system in patients with severe cerebral trauma II.

Auer

Ott

1979

Acta neurochir

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Platelet number, spontaneous aggregation, ADP- and adrenaline-induced aggregation, fibrinogen, and factors 2, 5, 7, and 10, were investigated in a series of 40 consecutive patients admitted to the clinic following severe head injury. Data were evaluated daily during the first week after trauma. Platelets were significantly decreased, particularly in non-survivors; there was no pathological spontaneous aggregation, except in a group of 22.5% of cases who had a mean age of 23.5 years. ADP-induced aggregation was negative in 69% of cases, and adrenaline-induced aggregation was absent in only two non-survivors. Fibrinogen was markedly reduced during the first five days, thereafter normalizing or increasing towards the end of the week. The other investigated values remained within their normal range of 70--130%. The results give no evidence of disseminated intravascular coagulation as a generalized and frequent phenomenon in severely head injured patients. There are, however, signs of latent consumption coagulopathy, which support data from the literature that indicate focal microthrombosis in contused brain areas.

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Disturbances of the coagulatory system in patients with severe cerebral trauma II.

Auer

Ott

1979

Acta neurochir

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Disturbances of the coagulatory system in patients with severe cerebral trauma. I

Auer¹

1978

Acta neurochir

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This is an investigation into thromboplastin time, partial thromboplastin time, plasma thrombin time, fibrinogen, and platelets in 30 patients with severe brain injury over 7--14 days. Platelets showed a very marked initial decrease and a slow return to normal around the seventh day. Fibrinogen was initially lowered in most of the cases, and raised from the second day onward. Changes in the other laboratory values were less definite. Latent signs of consumption coagulopathy were not accompanied by bleeding disorders, or by disseminated intravascular coagulation at autopsy. The severity of laboratory value changes clearly correlated with the extent of brain damage, and was significantly higher when the patient did not survive the first week after injury.

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Disseminated Intravascular Coagulation and Head Injury

Cited by 2 publications

References 5 publications

Disturbances of the coagulatory system in patients with severe cerebral trauma II.

Disturbances of the coagulatory system in patients with severe cerebral trauma II.

Disturbances of the coagulatory system in patients with severe cerebral trauma. I

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