Disseminated Mycobacterium peregrinum and Mycobacterium avium infection in a patient with AIDS: A case report and review of literature

Lao, Chong Kei; Wu, Ting‐Shu; Lin, Kuanyin K.; Lee, Ming-Hsun

doi:10.1016/j.jctube.2022.100314

Cited by 4 publications

(5 citation statements)

References 24 publications

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“…É essencial que seja realizado o diagnóstico ao nível de espécime das MNT para escolha adequada do tratamento. No entanto, é um diagnóstico complexo, sendo necessário uma correlação clínica e laboratorial e contaminação de amostras, uma vez que essas bactérias estão disseminadas no ambiente (LAO, 2022;NOGUEIRA, 2021). Há certa limitação, devido à escassez de pesquisas recentes sobre o assunto e ao fato de o último protocolo americano de conduta diagnóstica para MNT ser publicado no ano de 2007.…”

Section: Diagnósticounclassified

“…Quando na pele, osso e tecidos moles o diagnóstico é feito pela cultura do patógeno específico a partir do material de drenagem ou biópsia tecidual, sendo a última o método mais sensível (GRIFFITH, 2007;NOGUEIRA, 2021). Por fim, para diagnóstico das infecções disseminadas alguns estudos definem como cultura isolada de MNT no sangue ou na medula óssea, ou isolamento do MNT em uma biópsia hepática ou de dois ou mais órgãos não contíguos (LAO, 2022;WILDNER, 2011).…”

Section: Diagnósticounclassified

“…A doença pulmonar causada pelas MNT é frequente em pacientes que apresentem condições preexistentes, tais como fibrose cística, tuberculose prévia, doença pulmonar obstrutiva crônica (DPOC), pós-transplante seja de órgãos sólidos ou de medula óssea e em pacientes que vivem com infecção pelo vírus da imunodeficiência humana (HIV), principalmente devido à imunossupressão desses últimos (MARQUES, 2019). Dentre a população com HIV e/ou Síndrome da imunodeficiência adquirida (SIDA), as infecções pelas MNT disseminadas são reconhecidas com mais frequência, sendo os microrganismos dos Complexo M. avium (MAC)-(M. avium, M. avium subespécie paratuberculosis, M. intracellulare e M. scrofulaceum) os mais prevalentes (LAO, 2022;WILDNER, 2011).…”

Section: Introductionunclassified

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Micobactérias atípicas/ não tuberculosas Revisão Literária

Assis¹,

Aguiar²,

Fernandes³

2023

Patógenos Emergentes E Reemergentes

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Patógenos Emergentes e Reemergentes Introdução: As micobacterioses atípicas são patologias ocasionadas por micobactérias não tuberculosas, microrganismos que apresentam patogenia variável a depender do germe causador, podendo ocasionar uma série de infecções, incluindo doenças pulmonares, principalmente crônicas, e extrapulmonares. Objetivo: Esse trabalho objetiva reunir informações científicas sobre as formas de classificação, epidemiologia, patogenia, principais manifestações clínicas, diagnóstico, tratamento e profilaxia das micobacterioses não tuberculínicas. Material e Métodos: Foram revisados documentos científicos publicados em plataformas de referência, após o ano de 1999, sobre a temática abordada. Resultados: A patologia afeta indivíduos imunocompetentes e imunocomprometidos, sendo os últimos mais comumente acometidos. A clínica é similar à Tuberculose, fazendo com que o diagnóstico possa ser tardio, consequentemente ocasionando em um atraso no início do tratamento e por conseguinte, aumento da morbimortalidade. Pela sua complexidade, é de suma importância a associação da clínica do paciente com exames laboratoriais e de imagem para o seguimento do caso e escolha terapêutica adequada. Conclusão: A realização de estudos atualizados sobre as micobactérias não tuberculosas é de extrema importância, visto o aumento do número de casos e sua similaridade quando comparadas ao Mycobacterium tuberculosis.

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Section: Diagnósticounclassified

Section: Introductionunclassified

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Micobactérias atípicas/ não tuberculosas Revisão Literária

Assis¹,

Aguiar²,

Fernandes³

2023

Patógenos Emergentes E Reemergentes

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“…Notably, Mpgm induced sporadic invasive infections even in immunocompetent patients. Furthermore, pneumonia caused by Mpgm was reported in two previously healthy patients (2/4, 50%) [7]. Despite its clinical significance, there is limited understanding of the host immune response to Mpgm infection, and no studies have investigated in vitro differential immune responses based on morphological analysis.…”

Section: Introductionmentioning

confidence: 99%

Differential Immune Responses and Underlying Mechanisms of Metabolic Reprogramming in Smooth and Rough Variants of Mycobacterium peregrinum Infections

Lee,

Kim,

et al. 2023

Pathogens

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Mycobacterium peregrinum (Mpgm) is a rapidly growing mycobacteria that is classified as a nontuberculous mycobacterium (NTM) and is commonly found in environmental sources such as soil, water, and animals. Mpgm is considered an opportunistic pathogen that causes infection in immunocompromised individuals or those with underlying medical conditions. Although there have been clinical reports on Mpgm, reports of the immune response and metabolic reprogramming have not been published. Thus, we studied standard Mpgm-ATCC and two clinical strains (Mpgm-S and Mpgm-R) using macrophages and mouse bone marrow-derived cells. Mpgm has two types of colony morphologies: smooth and rough. We grew all strains on the 7H10 agar medium to visually validate the morphology. Cytokine levels were measured via ELISA and real-time PCR. The changes in mitochondrial function and glycolysis in Mpgm-infected macrophages were measured using an extracellular flux analyzer. Mpgm-S-infected macrophages showed elevated levels of inflammatory cytokines, including interleukin (IL)-6, IL-12p40, and tumor necrosis factor (TNF)-α, compared to Mpgm-ATCC- and Mpgm-R-infected macrophages. Additionally, our findings revealed metabolic changes in Mpgm-ATCC and two clinical strains (Mpgm-S and Mpgm-R) during infection; significant changes were observed in the mitochondrial respiration, extracellular acidification, and the oxygen consumption of BMDMs upon Mpgm-S infection. In summary, within the strains examined, Mpgm-S displayed greater virulence, triggered a heightened immune response, and induced more profound shifts in bioenergetic metabolism than Mpgm-ATCC and Mpgm-R. This study is the first to document distinct immune responses and metabolic reorganization following Mpgm infection. These findings lay a crucial foundation for further investigations into the pathogenesis of Mpgm.

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“…Они имеют преимущественно внелегочную локализацию -инфекции кожи, мягких тканей, ран или костей после травматических повреждений, хирургических операций или косметических процедур[11,15,17,22]. Заболевания легких и диссеминированные инфекции, вызванные микобактериями MFC, встречаются редко и преимущественно у пациентов с нарушениями иммунитета[21,23,25].Как и большинство других видов НТМБ, MFC, как правило, устойчивы к противотуберкулезным (ПТП) и другим антибактериальным препаратам (АБП), в связи с чем лечение микобактериозов, вызванных этими видами, является сложной задачей [1, 5, 7, 31]. К сожалению, лекарственные средства для лечения микобактериозов специально не разрабатывают, поэтому в данной ситуации логичным является испытание новых препаратов, активных в отношении M. tuberculosis.…”

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In Vitro Activity of Bedaquiline Against Mycobacterium Fortuitum Complex

Makarova,

Mikhailova,

Sviridenko

et al. 2024

TSZZ

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The activity of bedaquiline (Bdq), a drug that is effectively used for the treatment of tuberculosis, including those with multiple (MDR) and extensively drug resistant (XDR) pathogen, was studied against rapidly growing non-tuberculous mycobacteria (NTM) belonging to Mycobacterium fortuitum complex (MFC). Methods. А total 154 strains of MFC (78 of M. fortuitum and 76 of M. peregrinum) were examined. In addition, the drug susceptibility (DS) of these strains to 15 antibacterial drugs (ABD) was studied using the Sensitititre RapMyco test system. Results. Тhe Bdq MIC range for M. fortuitum was found to be 0.0015–1.0 μg/mL, M. peregrinum – 0.0015–2.0 μg/mL. The MIC50 for M. fortuitum was 0.015 µg/mL, MIC90 was 0.25 µg/mL, and ECOFF was 0.5 µg/mL. For M. peregrinum, the corresponding values were 0.007, 0.06 and 2.0 µg/mL. As a result, only 1 (1.3%) resistant strain of M. fortuitum was detected, no resistant strains of M. peregrinum were found. When the DS of these NTM species to other ABDs were studied, it was found that M. fortuitum and M. peregrinum were highly resistant to most of them. Conclusion. Bdq was found to be active against MFC in vitro and is likely to be effective in the chemotherapy of mycobacteriosis caused by these NTM species

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Disseminated Mycobacterium peregrinum and Mycobacterium avium infection in a patient with AIDS: A case report and review of literature

Cited by 4 publications

References 24 publications

Micobactérias atípicas/ não tuberculosas Revisão Literária

Micobactérias atípicas/ não tuberculosas Revisão Literária

Differential Immune Responses and Underlying Mechanisms of Metabolic Reprogramming in Smooth and Rough Variants of Mycobacterium peregrinum Infections

In Vitro Activity of Bedaquiline Against Mycobacterium Fortuitum Complex

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