Disseminated Nocardia farcinica infection in a patient with systemic lupus erythematosus

Abstract

Here, we describe a patient with disseminated systemic nocardiosis. He had a history of systemic lupus erythematosus and had received oral prednisolone for 7 months. Nocardia farcinica was isolated from the pus. There were neither clinical nor radiologic features of pulmonary nocardiosis. The patient was treated with oral trimethoprim/sulfamethoxazole, intravenous imipenem and surgical drainage with a good clinical response, and there has been no recurrence of the infection.

Disseminated Nocardiosis that Mimicked Polypyomyositis: A Case Report

“…In humans, nocardiosis usually affects immunocompromised hosts, and ranges from a selflimiting, subclinical condition to an acute, life threatening and disseminated disease 7) . The most common infection site is the lung, from which bacteria may disseminate to multiple sites, including the brain, kidneys, joints, soft tissues, and eyes, via hematogenous spread 8) . Pulmonary nocardiosis has been associated with mortality rates of 14%-40%; however, mortality increases significantly if the condition is complicated by a central nervous system infection.…”

Systemic Nocardia brasiliensis infection in a patient with systemic lupus erythematosus: successful diagnosis and therapy

“…The patient was treated successfully by using trimethoprim–sulfamethoxazole and linezolid for eight months. Hara et al . described a patient with SLE with disseminated N. farcinica infection.…”

Disseminated <i>Nocardia</i> infection presenting as hemorrhagic pustules and ecthyma in a woman with systemic lupus erythematosus and antiphospholipid antibody syndrome

“…[5][6][7][8] Corticosteroid use in association with Nocardia has also been reported with autoimmune blistering disease, ulcerative colitis, and other systemic autoimmune and inflammatory conditions. [9][10][11][12] A case control study in transplant recipients identified high dose steroids as the most significant independent risk factor for developing Nocardia infection.…”