Disseminated peritoneal leiomyomatosis: a rare entity with diagnostic conundrum

Saha, Pradip Kumar; Dhaliwal, Lakhbir Kaur; Gainder, Shalini; Bagga, Rashmi; Joshi, Bharti; S, Saha; Gupta, Rajesh

doi:10.18203/2320-1770.ijrcog20150454

Cited by 5 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Disseminated Peritoneal Leiomyomatosis (DPL) is a rare benign disease, often giving the appearance of metastatic ovarian or peritoneal carcinoma. The estimated prevalence of DPL is < 1/10,00,000 with fewer than 150 cases reported in literature to this date [2]. Such a case was first described by Willson and Peale in 1952 [3].…”

Section: Discussionmentioning

confidence: 99%

“…Because regression has been described with declining levels of estrogen (i.e., menopause), bilateral salpingooophorectomy or GnRh (Gonadotropin Releasing Hormone) analogue therapy should be considered before contemplating surgical excision of the metastatic nodules. Surgical excision of the metastatic nodules is necessary in the rare patient with large symptomatic lesions that are refractory to hormonal therapy or in patients who refuse surgical castration [1,2,9,12]. Hysterectomy per se is not beneficial but is considered in patients with associated uterine symptoms [13].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Disseminated peritoneal leiomyomatosis: an unusual presentation of intra-abdominal lesion mimicking disseminated malignancy

Soni

Pareek

Narayan

2020

Medicine and Pharmacy Reports

View full text Add to dashboard Cite

Leiomyoma are commonly seen as benign smooth muscle tumors of the uterus. Smooth muscle tumors with unusual growth pattern are rare and include 3 primary neoplasms: intravenous leiomyomatosis (IVL), benign metastasizing leiomyoma (BML) and disseminated peritoneal leiomyomatosis (DPL). DPL is a rare benign disease, often giving the appearance of metastatic ovarian or peritoneal carcinoma. It is a disease that predominately affects women at their reproductive age. The risk of malignant transformation is 2-5%. There are no standard treatment guidelines for the management of the DPL. The unusual presentation of the disease delays the diagnosis or is often misdiagnosed and thus over treated, which may lead to increased morbidity and mortality. Therefore careful consideration and high index of suspicion is required for the proper management of such cases.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Disseminated peritoneal leiomyomatosis: an unusual presentation of intra-abdominal lesion mimicking disseminated malignancy

Soni

Pareek

Narayan

2020

Medicine and Pharmacy Reports

View full text Add to dashboard Cite

show abstract

“…It was first described by Willson and Peale in 1952 [ 1 ]. The pathophysiology of DPL is still not fully understood but the involvement of a complex interaction between genetic predispositions, submesothelial multipotent cell metaplasia, and hormonal stimulation is hypothesized [ 2 , 3 ]. Travassoli and Norris suggested that DPL was abetted by the hormonal effect [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Disseminated Peritoneal Leiomyomatosis With Unusual Lung Mesenchymal Malignant Transformation

Buhusayyen¹,

Alkhan²,

Behzad³

et al. 2022

Cureus

View full text Add to dashboard Cite

Disseminated peritoneal leiomyomatosis (DPL) is a benign metastasis of leiomyoma mimicking metastasis of malignancy. It usually affects premenopausal women. Malignant transformation is a rare clinical scenario of DPL. However, its etiology is unknown with unusual growth patterns, either of which makes the diagnosis difficult. It was postulated that the pathophysiology of DPL is metaplasia of mesothelial cells under the effect of hormonal stimulation. Hence, we reported the case of a 62-year-old woman with a history of left breast cancer, who presented with DPL and metastasis to the lung with malignant transformation after two years of starting prophylactic tamoxifen therapy. The influence of tamoxifen use on the development of DPL is not fully understood; this is a rare case that highlights a possible association between tamoxifen and the malignancy transformation of DPL. Hence, it may help raise awareness among clinicians dealing with women using tamoxifen or other hormonal therapy, and the risk of DPL development with potential malignant transformation in such patients.

show abstract

“…It is characterized by the presence of multiple smooth muscle nodules on the peritoneal surface. To date, fewer than 140 cases have been reported in the literature and the estimated prevalence of LPD is <1/1.000.000 7 . The etiology of LPD is unknown.…”

mentioning

confidence: 99%

Peritoneal karsinomatozisi taklit eden dissemine peritoneal leiomyomatozis

Erbay

YALÇIN

2022

Cukurova Medical Journal

View full text Add to dashboard Cite

Dissemine peritoneal leiomyomatozis (DPL) genellikle premenopozal kadınları etkileyen iyi huylu ve çok nadir bir hastalıktır. 39 yaşında intramural leiomyomu ve dissemine peritoneal leiomyomatozisi olan bir kadın hastayı sunuyoruz. DPL'in kesin tedavisi hastalığın derecesine göre değişen derecede cerrahi olarak yapılmaktadır. Agresif tedavi kararı verilmeden önce peritoneal fibroidlerin malign peritoneal tümörleri taklit edebileceği akılda tutulmalıdır.

show abstract

Disseminated peritoneal leiomyomatosis: a rare entity with diagnostic conundrum

Cited by 5 publications

References 12 publications

Disseminated peritoneal leiomyomatosis: an unusual presentation of intra-abdominal lesion mimicking disseminated malignancy

Disseminated peritoneal leiomyomatosis: an unusual presentation of intra-abdominal lesion mimicking disseminated malignancy

Disseminated Peritoneal Leiomyomatosis With Unusual Lung Mesenchymal Malignant Transformation

Peritoneal karsinomatozisi taklit eden dissemine peritoneal leiomyomatozis

Contact Info

Product

Resources

About