Dissemination of a Clone of Unusual Phenotype of Pandrug-Resistant
            <i>Acinetobacter baumannii</i>
            at a University Hospital in Taiwan

Kuo, Lu-Cheng; Teng, Lee‐Jene; Yu, Chong‐Jen; Ho, Shen‐Wu; Hsueh, Po-Ren

doi:10.1128/jcm.42.4.1759-1763.2004

Cited by 59 publications

(56 citation statements)

References 22 publications

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“…Since PRA was first reported from Taiwan in 1998, there has been a global trend of evolution of MDRA to PRA [21]. This increase in pan-resistance has been observed in our medical centre over the past few years as well, and has led to the almost exclusive use of polymyxin as treatment in our patients for Acinetobacter infections [1].…”

Section: Discussionmentioning

confidence: 99%

Acinetobacter species meningitis in children: a case series from Karachi, Pakistan

Saleem

Shah

Shaikh

et al. 2011

J Infect Dev Ctries

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Introduction: Multidrug-resistant strains of Acinetobacter pose a serious therapeutic dilemma in hospital practice, particularly when they cause meningitis, as the few antimicrobial agents to which these isolates are susceptible have poor central nervous system (CNS) penetration. Methodology: We retrospectively reviewed the clinical course and outcome of eight consecutive cases of meningitis due to Acinetobacter spp. in children ages 15 years or less, seen in a tertiary care medical center in Karachi, Pakistan. Results: Of the eight cases of Acinetobacter meningitis, isolates from five patients were pan-resistant, and two were multidrug-resistant. A neurosurgical procedure was performed in five of eight patients followed by external ventricular drain insertion prior to the development of infection. Seven received intravenous (IV) polymyxin (mean; 12.8 days), while 5/8 also received intrathecal (IT) polymyxin (mean; 12.0 days). The mean length of hospitalization was 38.7 ± 19 days. All patients achieved cerebrospinal fluid (CSF) culture negativity by the end of treatment (mean; 5.4 days). Two patients died: one with pan-resistant Acinetobacter, and the second with a multi-drug resistant isolate. Conclusion: Post-neurosurgical multidrug-resistant and pan-resistant Acinetobacter meningitis can be successfully treated if appropriate antimicrobial therapy is instituted early. The role of IT polymyxin B administration alone versus combination therapy (IV and IT) needs further study.

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Section: Discussionmentioning

confidence: 99%

Acinetobacter species meningitis in children: a case series from Karachi, Pakistan

Saleem

Shah

Shaikh

et al. 2011

J Infect Dev Ctries

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“…En el presente trabajo, las patologías subyacentes de los pacientes fueron similares a las reportadas en otras series 16,17 . Los pacientes con mayor riesgo de adquisición de bacteriemia por ABM fueron aquellos con cardiopatías congénitas y los internados en la unidad de quemados.…”

Section: Discussionunclassified

“…Las UCI son un lugar frecuente de adquisición de ABM; esto tiene relación con el tipo de pacientes internados, la exposición a procedimientos invasores y a esquemas antimicrobianos de amplio espectro, sumado a la posible transmisión horizontal que puede ocurrir ocasionando brotes [16][17][18] .…”

Section: Discussionunclassified

Factores de riesgo para la adquisición y características microbiológicas de las bacteriemias por Acinetobacter baumannii multi-resistente en pediatría: Estudio de casos y controles

Ruvinsky

Fiorilli

Pérez

et al. 2015

Rev. chil. infectol.

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“…The infections caused by these bacteria are difficult to be treated with antibiotics and are associated with a higher rate of mortality because few or no adequate therapeutic option exists (Kuo et al, 2004;Deplano et al, 2005;Falagas et al, 2005;Shah, 2005). According to National Nosocomial Infections Surveillance (NNIS), the prevalence of resistance in both pathogens is a significantly increasing trend (Gaynes and Edwards, 2005).…”

mentioning

confidence: 99%

Probiotics with Antimicrobial Activity against Multidrug Resistant Pseudomonas aeruginosa and Acinetobacter baumannii

Lee¹,

Kim²,

Kang³

et al. 2013

The Korean Journal of Microbiology

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Pseudomonas aeruginosa and Acinetobacter baumannii are significant opportunistic pathogens in hospitals and are resistant to most antibiotics. Multidrug-resistant P. aeruginosa (MDRPA) and A. baumannii (MDRAB) cause severe human nosocomial infections and are more difficult to treat than methicillin-resistant Staphylococcus aureus (MRSA). Bifidobacteria are among of the most beneficial probiotics and have been widely studied for their antimicrobial activities. The present study explored the antimicrobial activity of Bifidobacterium sp. isolated from healthy Koreans against MDRPA and MDRAB. The antimicrobial activity of the isolates against MDRPA and MDRAB, which are resistant to ciprofloxacin, tobramycin, gentamicin, meropenem, and ceftazidime, was determined by modified broth microdilution methods using absorbance. Among all tested bifidobacteria isolates (nine B. adolescentis, three B. longum, and two B. pseudocatenulatum), the culture supernatant of B. pseudocatenulatum SPM1309 showed a strong growth inhibitory effect against MDRPA and MDRAB. No change in the turbidity of the mixture was observed during incubation, and its inhibitory effect occurred through bacteriostastic action. Moreover, the antibacterial activity was observed in the fraction with molecular weights <10 kDa of bifidobacteria culture supernatant, and the active fraction was heat-stable because it maintained its activity when heated at 70℃ for 10 min. The results suggest that this Bifidobacterium strain could have potential applications for alternative therapy in MDRPA and MDRAB infections.

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Dissemination of a Clone of Unusual Phenotype of Pandrug-Resistant Acinetobacter baumannii at a University Hospital in Taiwan

Cited by 59 publications

References 22 publications

Acinetobacter species meningitis in children: a case series from Karachi, Pakistan

Acinetobacter species meningitis in children: a case series from Karachi, Pakistan

Factores de riesgo para la adquisición y características microbiológicas de las bacteriemias por Acinetobacter baumannii multi-resistente en pediatría: Estudio de casos y controles

Probiotics with Antimicrobial Activity against Multidrug Resistant Pseudomonas aeruginosa and Acinetobacter baumannii

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