Dissemination of multiple MRSA clones among community-associated methicillin-resistant Staphylococcus aureus infections from Japanese children with impetigo

Predominant Dissemination of PVL-Negative CC89 MRSA with SCCmecType II in Children with Impetigo in Japan

“…However, in very recent studies, MRSA strains isolated from patients with impetigo had diverse SCC mec types, and SCC mec type IIb has been increasing [23, 24]. Type IIb SCC mec was first identified from MRSA strains isolated from healthy Japanese children [17].…”

“…Hisata et al characterized 17 MRSA strains isolated from patients with impetigo at a Japanese hospital from June through August 2002. They found that the 17 MRSA strains carried diverse types of SCC mec : type II (IIb: 4 strains; unknown subtype: 2 strains), type IV (7 strains), and type V (4 strains) [23]. Shi et al reported that among 26 MRSA strains isolated from patients with impetigo, 57.7% carried type IIa SCC mec element and 42.3% carried type IV SCC mec element [24].…”

“…In this study, none of the MRSA isolates carried the PVL gene. Although highly virulent CA-MRSA strains carrying PVL genes are known to prevail in the world, the prevalence of PVL-positive strains in Japan is not high [15, 17, 18, 23, 25]. There are three serological forms of ET, ETA, ETB, and ETD, which are linked to human impetigo [19].…”

“…Although highly virulent CA-MRSA strains carrying Panton-Valentine leukocidin (PVL) genes have been spreading widely in the world, PVL-negative CA-MRSA has been disseminated in Japan [15, 17, 18, 23, 25]. The aim of this study was to investigate the molecular epidemiology by multilocus sequence typing (MLST) and staphylococcal cassette chromosome mec (SCC mec ) typing and the antimicrobial susceptibilities of S. aureus isolates from children with impetigo.…”

Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Isolated from Children in a Community with Low Antimicrobial Pressure in Japan

“…In addition, to our knowledge, we report the first detection of the ST81/SCCmecIVg strain in Japan. Berglund et al (16) and Hisata et al (26) previously reported that SCCmecIVg strains belonged to ST1, ST30, ST45, ST59, ST88, and ST140 in Sweden and Japan. In our study, the SCCmecIVg strain was found to belong to ST81, suggesting that SCCmecIVg may show different molecular characteristics according to the country of circulation.…”