Many people have not implemented health protocols according to government advice, such as not washing hands and wearing masks in public; thus, COVID-19 pandemic transmission has rapidly occurred. This cause is mostly the citizen’s lack of awareness in implementing 3 M (memakai masker, menjaga jarak, mencuci tangan in English read washing hands, wearing masks, and maintaining distance). The status quo becomes the researcher’s foundation in developing a pentahelix integrated health protocol education model for handling COVID-19 based on Tri Hita Karana. This development research refers to the prototyping model according to Nieveen that covers (1) preliminary research, (2) the prototyping stage, and (3) the assessment stage. The research subjects were 100 people. The data collection method used a questionnaire of community appreciation that measures knowledge and the community’s level of awareness. The data analysis used was a t test. The results of the research show that the model of pentahelix integrated health protocol education for the handling of COVID-19 based on Tri Hita Karana was effectively used to improve the community’s appreciation of conducting health protocols. This is shown by the improvement of average values before and after the implementation. Thus, it can be recommended as a solution to COVID-19 prevention.