Dissemination of tumour cells from fine needle biopsy.

Redwood, N.F.W.; Beggs, D; Morgan, William E.

doi:10.1136/thx.44.10.826

Cited by 23 publications

(5 citation statements)

References 2 publications

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“…Despite high diagnostic accuracy and low short term complications have been widely studied for years, it is necessary to understand the long term comorbidities like pleural recurrence related to diagnostic procedure. Some typical cases with pleural recurrence and needle tract implantation have been identified since 1965 when PTNB was firstly reported to be used 4 5 21 22 23 . A cohort study, however, was lack until 2005 Matsuguma, et al .…”

Section: Discussionmentioning

confidence: 99%

“…Percutaneous transthoracic needle biopsies (PTNB) are widely used for the histologic diagnosis of a peripheral indeterminate pulmonary nodule and reported a high diagnostic yield of 90% sensitivity and 97% specificity 1 2 . However, pleural recurrence was also reported as a long term complication of PTNB in many literatures 3 4 5 6 . Recent evidence focusing on recurrent outcomes after PTNB was controversial 7 8 9 10 11 .…”

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confidence: 99%

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Risk of Pleural Recurrence in Early Stage Lung Cancer Patients after Percutaneous Transthoracic Needle Biopsy: A Meta-analysis

Wang

Zhou

2017

Sci Rep

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Percutaneous transthoracic needle biopsies (PTNB) are widely used for the diagnosis of a peripheral pulmonary nodules, but the risk of pleural recurrence in lung cancer patients remains undetermined. Our meta-analysis aims to answer the question whether PTNB strategy increases the risk of recurrence. PubMed, EMBASE, The Cochrane Library, and China National Knowledge Infrastructure (CNKI) were searched from inception to January 9, 2016. A total of 1242 patients from 5 studies were included. The results showed that PTNB does not increase risk of total recurrence (Odds Ratio,0.78; 95% CI, 0.53 to 1.15) or pleural recurrence (Odds Ratio,1.58; 95% CI, 0.41 to 6.12) compared with non-PTNB strategies in early stage lung cancer patients. Subgroup analysis showed that PTNB was associated with increased pleural recurrence (Odds Ratio, 10.76; 95% CI, 2.92 to 39.70) in patients with sub-pleural lesions but not in patients without sub-pleural lesions (Odds Ratio, 0.96; 95% CI, 0.24 to 3.89). In conclusion, PTNB should not be recommended in lung cancer patients with sub-pleural lesions. However, PTNB is recommendable to use in other patients without sub-pleural lesions to whom pathological diagnosis is necessary, especially in patients with relevant comorbidities.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Risk of Pleural Recurrence in Early Stage Lung Cancer Patients after Percutaneous Transthoracic Needle Biopsy: A Meta-analysis

Wang

Zhou

2017

Sci Rep

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“…Seeding of malignant cells in the needle tract following PNB is also rare; only two cases were reported by Muller et al in a review of 5300 patients [61]. There have been other occasional reports of tumor cell dissemination [62][63][64][65][66][67][68][69], including a report of two cases in which there was cancer dissemination into the pleural space [70]. It has been suggested that the risk of tumor cell seeding must be strongly considered when deciding whether to biopsy potentially operable malignant lesions [71].…”

Section: Tumor Implantationmentioning

confidence: 99%

Percutaneous Needle Biopsy of the Lung and Its Impact on Patient Management

2001

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Percutaneous needle biopsy (PNB) of the lung is a commonly performed procedure, mainly used for the investigation of solitary pulmonary nodules. Developments in imaging, particularly computed tomography (CT), have enable accurate preliminary assessment and targeting of lesions. Improvements in needle design ensure the provision of diagnostic samples for both cytologic and histologic assessment; and the development of immunocytochemistry and immunohistochemistry have allowed improved accuracy in diagnosis. A significant improvement in diagnostic accuracy for benign lesions has been associated with the use of cutting needles that provide cores for histologic diagnosis, in contrast to cytologic analysis from fine-needle aspiration. The complications of PNB are well recorded and have not changed significantly with the newer imaging techniques and needles. The preliminary assessment of solitary pulmonary nodules, and the pretest likelihood of malignancy, has improved using contrast-enhanced CT and positron emission tomography; the latter modality is increasingly having a major impact on the investigation of patients with suspected malignancy. The performance of PNB must always be determined on an individual case basis and when the result is likely to affect management. The complementary roles of PNB, bronchoscopic biopsy, and video-assisted thoracoscopic biopsy continue to evolve.

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“…Iatragenic seeding has been reported in patients with hepatocellular carcinoma, bronchogenic carcinoma (5), prostate cancer (6), and brain cancer, as well as many other types of histopathologic malignancies following needle biopsy. The incidence of tumor seeding associated with needle biopsy increases progressively with larger needle diameters (2,3).…”

Section: Discussionmentioning

confidence: 99%

Local Recurrence of Breast Cancer in the Stereotactic Core Needle Biopsy Site: Case Reports and Review of the Literature

Chao¹,

Torosian²,

Boraas³

et al. 2001

Breast Journal

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Early mammographic detection of nonpalpable breast lesions has led to the increasing use of stereotactic core biopsies for tissue diagnosis. Tumor seeding the needle tract is a theorectical concern; the incidence and clinical significance of this potential complication are unknown. We report three cases of subcutaneous breast cancer recurrence at the stereotactic biopsy site after definitive treatment of the primary breast tumor. Two cases were clinically evident and relevant; the third was detected in the preclinical, microscopic state. All three patients underwent multiple passes during stereotactic large-core biopsies (14 gauge needle) followed by modified radical mastectomy. Two patients developed a subcutaneous recurrence at the site of the previous biopsy 12 and 17 months later; one had excision of the skin and dermis at the time of mastectomy revealing tumor cells locally. In summary, clinically relevant recurrence from tumor cells seeding the needle tract is reported in two patients after definitive surgical therapy (without adjuvant radiation therapy). Often, the biopsy site is outside the boundaries of surgical resection. Since the core needle biopsy exit site represents a potential area of malignant seeding and subsequent tumor recurrence, we recommend excising the stereotactic core biopsy tract at the time of definitive surgical resection of the primary tumor.

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Dissemination of tumour cells from fine needle biopsy.

Cited by 23 publications

References 2 publications

Risk of Pleural Recurrence in Early Stage Lung Cancer Patients after Percutaneous Transthoracic Needle Biopsy: A Meta-analysis

Risk of Pleural Recurrence in Early Stage Lung Cancer Patients after Percutaneous Transthoracic Needle Biopsy: A Meta-analysis

Percutaneous Needle Biopsy of the Lung and Its Impact on Patient Management

Local Recurrence of Breast Cancer in the Stereotactic Core Needle Biopsy Site: Case Reports and Review of the Literature

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